Decernotinib
Decernotinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase JAK3. In addition, it is known to target tyrosine-protein kinase JAK1 and tyrosine-protein kinase JAK2.
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Commercial
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Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 4 | 1 | — | — | 4 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 4 | 1 | — | — | 4 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Decernotinib |
| INN | decernotinib |
| Description | Decernotinib is an inhibitor of Janus kinase 3 (JAK3) discovered through a process of inhouse screening of a chemical compound library. Decernotinib also had the name VX-509 in development phase. It is an experimental drug with high selectivity for JAK3, which demonstrates good efficacy in vivo in the rat host versus graft model (HvG). It is being studied in clinical trials at Vertex.
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| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@@](C)(Nc1ccnc(-c2c[nH]c3ncccc23)n1)C(=O)NCC(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 944842-54-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3039513 |
| ChEBI ID | — |
| PubChem CID | 59422203 |
| DrugBank | — |
| UNII ID | MZK2GP0RHK (ChemIDplus, GSRS) |
Target
Agency Approved
JAK3
JAK3
Variants
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Safety
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Adverse Events
0 adverse events reported
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