Dasotraline
Dasotraline is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
13 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperkinesis | D006948 | — | — | 2 | 2 | 6 | — | — | 9 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | 2 | 2 | 6 | — | — | 9 |
| Bulimia | D002032 | — | F50.2 | 1 | 1 | 3 | — | — | 4 |
| Feeding and eating disorders | D001068 | — | F50 | 1 | 1 | 3 | — | — | 4 |
| Binge-eating disorder | D056912 | — | F50.2 | 1 | 1 | 3 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | 1 | — | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dasotraline |
| INN | dasotraline |
| Description | Dasotraline (INN; former developmental code name SEP-225,289) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that was under development by Sunovion for the treatment of attention-deficit hyperactivity disorder (ADHD) and binge eating disorder (BED). Structurally, dasotraline is a stereoisomer of desmethylsertraline (DMS), which is an active metabolite of the marketed selective serotonin reuptake inhibitor (SSRI) antidepressant sertraline (Zoloft).
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| Classification | Small molecule |
| Drug class | selective serotonin reuptake inhibitors (SSRI) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21 |
Identifiers
| PDB | — |
| CAS-ID | 675126-05-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3301595 |
| ChEBI ID | — |
| PubChem CID | 9947999 |
| DrugBank | — |
| UNII ID | 4D28EY0L5T (ChemIDplus, GSRS) |
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Safety
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