Sprycel(dasatinib)
Dasatinib, Phyrago, Sprycel (dasatinib) is a small molecule pharmaceutical. Dasatinib was first approved as Sprycel on 2006-06-28. It is used to treat lymphoid leukemia and myeloid leukemia in the USA. It has been approved in Europe to treat BCR-ABL positive chronic myelogenous leukemia and precursor cell lymphoblastic leukemia-lymphoma. The pharmaceutical is active against tyrosine-protein kinase ABL1. In addition, it is known to target putative serine/threonine-protein kinase SIK1B, proto-oncogene tyrosine-protein kinase Src, serine/threonine-protein kinase SIK2, and serine/threonine-protein kinase SIK3.
...
More
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Dasatinib, Phyrago, Sprycel
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dasatinib
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SPRYCEL | Bristol Myers Squibb | N-021986 RX | 2006-06-28 | 6 products, RLD |
| PHYRAGO | Handa Pharma | N-216099 RX | 2023-12-05 | 6 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| dasatinib | ANDA | 2025-03-04 |
| dasatinib dasatinib | ANDA | 2025-02-25 |
| phyrago | New Drug Application | 2024-12-13 |
| sprycel | New Drug Application | 2024-07-31 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| myeloid leukemia | — | D007951 | C92 |
| lymphoid leukemia | — | D007945 | C91 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
DASATINIB, SPRYCEL, BRISTOL MYERS SQUIBB | |||
| 2026-06-21 | PED | ||
| 2025-12-21 | ODE-225 | ||
| 2025-05-09 | PED | ||
| 2024-11-09 | ODE-164 | ||
HCPCS
No data
Clinical
Clinical Trials
392 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 55 | 104 | 22 | 8 | 35 | 201 |
| Myeloid leukemia | D007951 | — | C92 | 38 | 65 | 10 | 6 | 26 | 133 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 31 | 63 | 11 | 7 | 31 | 132 |
| Lymphoid leukemia | D007945 | — | C91 | 27 | 45 | 9 | 1 | 6 | 78 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 25 | 39 | 12 | 1 | 6 | 73 |
| Myeloid leukemia chronic-phase | D015466 | — | — | 7 | 25 | 3 | 3 | 9 | 46 |
| Multiple myeloma | D009101 | — | C90.0 | 7 | 5 | — | 1 | — | 13 |
| Plasma cell neoplasms | D054219 | — | — | 5 | 4 | — | 1 | — | 10 |
| Hematologic neoplasms | D019337 | — | — | 4 | 3 | — | 1 | — | 7 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Philadelphia chromosome | D010677 | — | — | 16 | 24 | 5 | — | 3 | 42 |
| Lymphoma | D008223 | — | C85.9 | 10 | 14 | 1 | — | 1 | 21 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 10 | 9 | 1 | — | 3 | 19 |
| Prostatic neoplasms | D011471 | — | C61 | 4 | 13 | 1 | — | — | 16 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | 2 | 1 | — | 3 | 7 |
| Myeloid leukemia accelerated phase | D015465 | — | — | 3 | 1 | 1 | — | — | 5 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | 2 | 3 | 1 | — | — | 5 |
| Residual neoplasm | D018365 | — | — | 1 | 3 | 1 | — | — | 4 |
| Central nervous system neoplasms | D016543 | — | — | 2 | 2 | 1 | — | — | 3 |
| Hematopoietic stem cell transplantation | D018380 | — | — | — | 1 | 1 | — | — | 1 |
Show 3 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 22 | 14 | — | — | 2 | 36 |
| Recurrence | D012008 | — | — | 11 | 11 | — | — | 2 | 23 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 8 | 20 | — | — | — | 22 |
| Carcinoma | D002277 | — | C80.0 | 6 | 10 | — | — | 1 | 17 |
| Lung neoplasms | D008175 | — | C34.90 | 5 | 11 | — | — | — | 14 |
| Non-small-cell lung carcinoma | D002289 | — | — | 6 | 9 | — | — | — | 13 |
| Blast crisis | D001752 | — | — | 8 | 5 | — | — | — | 12 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 5 | 8 | — | — | — | 11 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 6 | — | — | — | 10 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 7 | 5 | — | — | — | 10 |
Show 127 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hodgkin disease | D006689 | — | C81 | 4 | — | — | — | — | 4 |
| Mucinous adenocarcinoma | D002288 | — | — | 2 | — | — | — | — | 2 |
| Waldenstrom macroglobulinemia | D008258 | — | C88.0 | 2 | — | — | — | — | 2 |
| Mycoses | D009181 | — | B35-B49 | 2 | — | — | — | — | 2 |
| Mycosis fungoides | D009182 | — | C84.0 | 2 | — | — | — | — | 2 |
| Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | — | — | — | — | 1 |
| Anemia | D000740 | EFO_0004272 | D64.9 | 1 | — | — | — | — | 1 |
| Leukemia myeloid chronic atypical bcr-abl negative | D054438 | — | C92.2 | 1 | — | — | — | — | 1 |
| Myelodysplastic-myeloproliferative diseases | D054437 | — | — | 1 | — | — | — | — | 1 |
Show 32 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 1 | 1 |
| Pleural effusion | D010996 | — | J90 | — | — | — | — | 1 | 1 |
| Fatigue | D005221 | — | R53.83 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Dasatinib |
| INN | dasatinib |
| Description | Dasatinib (anhydrous) is an aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN). It has a role as a tyrosine kinase inhibitor, an anticoronaviral agent and an antineoplastic agent. It is a secondary amino compound, a tertiary amino compound, an organochlorine compound, an aminopyrimidine, a member of 1,3-thiazoles, a monocarboxylic acid amide, a N-arylpiperazine and a N-(2-hydroxyethyl)piperazine. It is a conjugate base of a dasatinib(1+). ... More |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1nc(Nc2ncc(C(=O)Nc3c(C)cccc3Cl)s2)cc(N2CCN(CCO)CC2)n1 |
Identifiers
| PDB | — |
| CAS-ID | 302962-49-8 |
| RxCUI | 1546019 |
| ChEMBL ID | CHEMBL1421 |
| ChEBI ID | 49375 |
| PubChem CID | 3062316 |
| DrugBank | DB01254 |
| UNII ID | X78UG0A0RN (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SRC
SRC
Organism
Homo sapiens
Gene name
SRC
Gene synonyms
SRC1
NCBI Gene ID
Protein name
proto-oncogene tyrosine-protein kinase Src
Protein synonyms
p60-Src, pp60c-src, Proto-oncogene c-Src, protooncogene SRC, Rous sarcoma, tyrosine kinase pp60c-src, tyrosine-protein kinase SRC-1, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
...
More
Uniprot ID
Mouse ortholog
Src (20779)
proto-oncogene tyrosine-protein kinase Src (Q2M4I4)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Sprycel – Bristol Myers Squibb
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 23,823 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
34,630 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use