Daprodustat
Jesduvroq (daprodustat) is a small molecule pharmaceutical. Daprodustat was first approved as Jesduvroq on 2023-02-01. It is used to treat anemia in the USA.
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Events
FDA approval date
EMA approval date
Patent expiration date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| hemic and lymphatic diseases | D006425 |
Trade Name
FDA
EMA
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| jesduvroq | New Drug Application | 2023-08-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| anemia | EFO_0004272 | D000740 | D64.9 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
DAPRODUSTAT, JESDUVROQ, GLAXOSMITHKLINE | |||
| 2028-02-01 | NCE | ||
HCPCS
No data
Clinical
Clinical Trials
36 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | 11 | 10 | 9 | 1 | — | 31 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 8 | 8 | 1 | — | 17 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 8 | 6 | 1 | — | 16 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | — | 1 | 1 | — | 3 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Aspergillosis | D001228 | EFO_0007157 | B44 | — | — | 1 | — | — | 1 |
| Allergic bronchopulmonary aspergillosis | D001229 | EFO_0007140 | B44.81 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | — | 1 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | 1 | — | — | — | 1 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | 1 | — | — | — | 1 |
| Aneurysm | D000783 | — | I72.9 | — | 1 | — | — | — | 1 |
| Thoracic aortic aneurysm | D017545 | EFO_0004282 | — | — | 1 | — | — | — | 1 |
| Operative surgical procedures | D013514 | — | — | — | 1 | — | — | — | 1 |
| Aortic aneurysm | D001014 | EFO_0001666 | I71.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Diabetic foot | D017719 | EFO_1001459 | — | 1 | — | — | — | — | 1 |
| Foot ulcer | D016523 | — | — | 1 | — | — | — | — | 1 |
| Wound healing | D014945 | GO_0042060 | — | 1 | — | — | — | — | 1 |
| Tendon injuries | D013708 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Daprodustat |
| INN | daprodustat |
| Description | Daprodustat is a member of the class of barbiturates that is barbituric acid substituted by cyclohexyl groups at positions 1 and 3, and by a (carboxymethyl)aminocarbonyl group at position 5. It is an inhibitor of hypoxia-inducible factor prolyl hydroxylase developed by GlaxoSmithKline for the treatment of anaemia in patients with chronic kidney disease. It has a role as an anti-anaemic agent and an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor. It is a member of barbiturates, a secondary carboxamide, a N-acylglycine and an oxo monocarboxylic acid. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 960539-70-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3544988 |
| ChEBI ID | — |
| PubChem CID | 91617630 |
| DrugBank | DB11682 |
| UNII ID | JVR38ZM64B (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 591 documents
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Safety
Black-box Warning
Black-box warning for: Jesduvroq
Adverse Events
Top Adverse Reactions
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1,455 adverse events reported
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