Dapansutrile
Dapansutrile is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target NACHT, LRR and PYD domains-containing protein 3.
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YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 1 | 1 | — | — | 1 |
| Arthralgia | D018771 | HP_0002829 | M25.5 | — | 1 | 1 | — | — | 1 |
| Gouty arthritis | D015210 | — | — | — | 1 | 1 | — | — | 1 |
| Gout | D006073 | EFO_0004274 | M10 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 2 | — | — | — | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 2 | — | — | — | 2 |
| Schnitzler syndrome | D019873 | EFO_1001165 | — | — | 1 | — | — | — | 1 |
| Covid-19 | D000086382 | — | — | — | 1 | — | — | — | 1 |
| Cytokine release syndrome | D000080424 | — | D89.83 | — | 1 | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | — | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | — | — | 1 |
| Systolic heart failure | D054143 | EFO_1001207 | I50.20 | 1 | — | — | — | — | 1 |
| Systolic murmurs | D054160 | — | R01.1 | 1 | — | — | — | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 1 | — | — | — | — | 1 |
| Infarction | D007238 | EFO_0009463 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dapansutrile |
| INN | dapansutrile |
| Description | Dapansutrile (OLT1177) is an inhibitor of the NLRP3 (nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3) inflammasome.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)CCC#N |
Identifiers
| PDB | — |
| CAS-ID | 54863-37-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989943 |
| ChEBI ID | — |
| PubChem CID | 12714644 |
| DrugBank | DB16130 |
| UNII ID | 2Z03364G96 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NLRP3
NLRP3
Organism
Homo sapiens
Gene name
NLRP3
Gene synonyms
C1orf7, CIAS1, NALP3, PYPAF1
NCBI Gene ID
Protein name
NACHT, LRR and PYD domains-containing protein 3
Protein synonyms
Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, cold autoinflammatory syndrome 1 protein, Cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, cryopyrin, NACHT, LRR and PYD domains - containing protein 3, deafness, autosomal dominant 34, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, NACHT, LRR and PYD containing protein 3, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3, PYRIN-containing APAF1-like protein 1
Uniprot ID
Mouse ortholog
Nlrp3 (216799)
NACHT, LRR and PYD domains-containing protein 3 (T1W2H6)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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