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Drug ReportsDapansutrile
Dapansutrile
Dapansutrile is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target NACHT, LRR and PYD domains-containing protein 3.
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Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ArthritisD001168HP_0001369M05-M14111
ArthralgiaD018771HP_0002829M25.5111
Gouty arthritisD015210111
GoutD006073EFO_0004274M10111
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SyndromeD01357722
OsteoarthritisD010003EFO_0002506M15-M1922
Schnitzler syndromeD019873EFO_100116511
Covid-19D00008638211
Cytokine release syndromeD000080424D89.8311
PainD010146EFO_0003843R5211
Knee osteoarthritisD020370EFO_0004616M1711
MelanomaD008545111
Type 2 diabetes mellitusD003924EFO_0001360E1111
Diabetes mellitusD003920HP_0000819E08-E1311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients22
Heart failureD006333HP_0001635I5011
Systolic heart failureD054143EFO_1001207I50.2011
Systolic murmursD054160R01.111
Myocardial infarctionD009203EFO_0000612I2111
InfarctionD007238EFO_000946311
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDapansutrile
INNdapansutrile
Description
Dapansutrile (OLT1177) is an inhibitor of the NLRP3 (nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3) inflammasome.
Classification
Small molecule
Drug class
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Structure (InChI/SMILES or Protein Sequence)
CS(=O)(=O)CCC#N
Identifiers
PDB
CAS-ID54863-37-5
RxCUI
ChEMBL IDCHEMBL3989943
ChEBI ID
PubChem CID12714644
DrugBankDB16130
UNII ID2Z03364G96 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NLRP3
NLRP3
Organism
Homo sapiens
Gene name
NLRP3
Gene synonyms
C1orf7, CIAS1, NALP3, PYPAF1
NCBI Gene ID
Protein name
NACHT, LRR and PYD domains-containing protein 3
Protein synonyms
Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, cold autoinflammatory syndrome 1 protein, Cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, cryopyrin, NACHT, LRR and PYD domains - containing protein 3, deafness, autosomal dominant 34, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, NACHT, LRR and PYD containing protein 3, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3, PYRIN-containing APAF1-like protein 1
Uniprot ID
Mouse ortholog
Nlrp3 (216799)
NACHT, LRR and PYD domains-containing protein 3 (T1W2H6)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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