Dapansutrile
Dapansutrile is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target NACHT, LRR and PYD domains-containing protein 3.
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Commercial
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Clinical
Clinical Trials
11 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dapansutrile |
| INN | dapansutrile |
| Description | Dapansutrile (OLT1177) is an inhibitor of the NLRP3 (nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3) inflammasome.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)CCC#N |
Identifiers
| PDB | — |
| CAS-ID | 54863-37-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989943 |
| ChEBI ID | — |
| PubChem CID | 12714644 |
| DrugBank | DB16130 |
| UNII ID | 2Z03364G96 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NLRP3
NLRP3
Organism
Homo sapiens
Gene name
NLRP3
Gene synonyms
C1orf7, CIAS1, NALP3, PYPAF1
NCBI Gene ID
Protein name
NACHT, LRR and PYD domains-containing protein 3
Protein synonyms
Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, cold autoinflammatory syndrome 1 protein, Cold-induced autoinflammatory syndrome 1 protein, Cryopyrin, cryopyrin, NACHT, LRR and PYD domains - containing protein 3, deafness, autosomal dominant 34, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3, NACHT, LRR and PYD containing protein 3, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3, PYRIN-containing APAF1-like protein 1
Uniprot ID
Mouse ortholog
Nlrp3 (216799)
NACHT, LRR and PYD domains-containing protein 3 (T1W2H6)
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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