Danoprevir
Danoprevir is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug
General
| Drug common name | Danoprevir |
| INN | danoprevir |
| Description | Danoprevir (INN) is an orally available 15-membered macrocyclic peptidomimetic inhibitor of NS3/4A HCV protease. It contains acylsulfonamide, fluoroisoindole and tert-butyl carbamate moieties. Danoprevir is a clinical candidate based on its favorable potency profile against multiple HCV genotypes 1–6 and key mutants (GT1b, IC50 = 0.2–0.4 nM; replicon GT1b, EC50 = 1.6 nM).
Danoprevir has been evaluated in an open-label, single arm clinical trial in combination with ritonavir for treating COVID-19 and favourably compared to lopinavir/ritonavir in a second trial.
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| Classification | Small molecule |
| Drug class | antivirals: serine protease inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)(C)OC(=O)N[C@H]1CCCCC/C=C\[C@@H]2C[C@@]2(C(=O)NS(=O)(=O)C2CC2)NC(=O)[C@@H]2C[C@@H](OC(=O)N3Cc4cccc(F)c4C3)CN2C1=O |
Identifiers
| PDB | — |
| CAS-ID | 850876-88-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL258734 |
| ChEBI ID | — |
| PubChem CID | 56841889 |
| DrugBank | DB11779 |
| UNII ID | 911Z9PCQ5F (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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