Dalteparin sodium
Fragmin (dalteparin sodium) is an oligosaccharide pharmaceutical. Dalteparin sodium was first approved as Fragmin on 1994-12-22. It is used to treat myocardial infarction, postoperative complications, pulmonary embolism, thromboembolism, and thrombophlebitis amongst others in the USA. The pharmaceutical is active against antithrombin-III.
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Clinical Trials
854 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thromboembolism | D013923 | — | — | 9 | 38 | 72 | 37 | 69 | 215 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | 9 | 34 | 68 | 30 | 62 | 194 |
| Thrombosis | D013927 | — | — | 11 | 30 | 52 | 37 | 72 | 191 |
| Venous thrombosis | D020246 | — | I82.40 | 8 | 27 | 44 | 36 | 46 | 153 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | 9 | 9 | 29 | 21 | 25 | 88 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 15 | 25 | 12 | 31 | 81 |
| Embolism | D004617 | — | — | 7 | 8 | 22 | 16 | 23 | 71 |
| Neoplasms | D009369 | — | C80 | 1 | 6 | 13 | 3 | 21 | 42 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 3 | 4 | 7 | 18 | 32 |
| Syndrome | D013577 | — | — | 4 | 7 | 5 | 4 | 7 | 25 |
Show 105 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 2 | 4 | 3 | — | 4 | 12 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 3 | 2 | — | 4 | 10 |
| Replacement arthroplasty knee | D019645 | — | — | — | 5 | 3 | — | — | 8 |
| Colorectal neoplasms | D015179 | — | — | — | 2 | 4 | — | 2 | 8 |
| Lymphoma | D008223 | — | C85.9 | 1 | 3 | 1 | — | 2 | 6 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | 1 | 2 | — | 3 | 6 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | — | 1 | 4 | — | 2 | 6 |
| Intracranial thrombosis | D020767 | — | — | — | 2 | 3 | — | 1 | 5 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 2 | 1 | — | 1 | 4 |
| Female genital neoplasms | D005833 | — | — | — | 1 | 2 | — | 1 | 4 |
Show 72 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | 2 | — | — | 1 | 10 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 4 | — | — | 1 | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 2 | — | — | 1 | 3 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | 3 | — | — | — | 3 |
| Pregnancy rate | D018873 | — | — | 1 | 1 | — | — | 1 | 3 |
| B-cell lymphoma | D016393 | — | — | 1 | 2 | — | — | — | 2 |
| Cytokine release syndrome | D000080424 | — | D89.83 | — | 1 | — | — | 1 | 2 |
| Staphylococcal infections | D013203 | — | A49.01 | — | 1 | — | — | 1 | 2 |
| Catheter-related infections | D055499 | — | — | — | 1 | — | — | 1 | 2 |
| Iga vasculitis | D011695 | EFO_1000965 | D69.0 | 1 | 1 | — | — | 1 | 2 |
Show 39 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood platelet disorders | D001791 | — | — | 1 | — | — | — | — | 1 |
| Balloon angioplasty coronary | D015906 | EFO_0003951 | — | 1 | — | — | — | — | 1 |
| Cesarean section | D002585 | — | — | 1 | — | — | — | — | 1 |
| Stillbirth | D050497 | — | P95 | 1 | — | — | — | — | 1 |
| Clear cell sarcoma | D018227 | — | — | 1 | — | — | — | — | 1 |
| Pseudotumor cerebri | D011559 | EFO_1001132 | G93.2 | 1 | — | — | — | — | 1 |
| Intracranial hypertension | D019586 | EFO_1000992 | — | 1 | — | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 7 | 7 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 6 | 6 |
| Ecchymosis | D004438 | — | — | — | — | — | — | 3 | 3 |
| Femoral fractures | D005264 | — | S72 | — | — | — | — | 3 | 3 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 2 | 2 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | — | — | — | 2 | 2 |
| Length of stay | D007902 | — | — | — | — | — | — | 2 | 2 |
| Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | — | — | — | 2 | 2 |
| Non-st elevated myocardial infarction | D000072658 | — | — | — | — | — | — | 2 | 2 |
| Artificial respiration | D012121 | — | — | — | — | — | — | 2 | 2 |
Show 105 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dalteparin sodium |
| INN | dalteparin sodium |
| Description | Dalteparin is a low molecular weight heparin. It is marketed as Fragmin. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of deep vein thrombosis and pulmonary embolism to reduce the risk of a stroke or heart attack. Dalteparin acts by potentiating the activity of antithrombin III, inhibiting formation of both Factor Xa and thrombin. It is normally administered by self-injection.
|
| Classification | Oligosaccharide |
| Drug class | heparin derivatives and low molecular weight (or depolymerized) heparins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | 67109 |
| ChEMBL ID | CHEMBL1201460 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB06779 |
| UNII ID | 12M44VTJ7B (ChemIDplus, GSRS) |
Target
Agency Approved
SERPINC1
SERPINC1
Organism
Homo sapiens
Gene name
SERPINC1
Gene synonyms
AT3
NCBI Gene ID
Protein name
antithrombin-III
Protein synonyms
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, Serpin C1, serpin peptidase inhibitor clade C member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Uniprot ID
Mouse ortholog
Serpinc1 (11905)
antithrombin-III (P32261)
Alternate
No data
Variants
No data
Financial
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Fragmin – Pfizer
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Estimated US medical usage
Dalteparin sodium
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Dalteparin
Total medical expenditures per year (USD, in millions)
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Safety
Black-box Warning
Black-box warning for: Fragmin
Adverse Events
Top Adverse Reactions
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5,898 adverse events reported
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