Ampyra, Fampyra(dalfampridine)
Ampyra, Dalfampridine (dalfampridine) is a small molecule pharmaceutical. Dalfampridine was first approved as Ampyra on 2010-01-22. It is used to treat multiple sclerosis and neurologic gait disorders in the USA.
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Commercial
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Ampyra, Dalfampridine (discontinued: Dalfampridine)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ampyra | New Drug Application | 2025-05-05 |
| dalfampridine | ANDA | 2025-07-28 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| multiple sclerosis | EFO_0003885 | D009103 | G35 |
| neurologic gait disorders | — | D020233 | R26.1 |
Agency Specific
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Clinical
Clinical Trials
270 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 1 | 3 | 3 | 2 | 9 |
| Sclerosis | D012598 | — | — | — | 1 | 3 | 3 | — | 7 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | 1 | — | — | 1 |
| Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dalfampridine |
| INN | fampridine |
| Description | 4-aminopyridine is an aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis. It has a role as an avicide, a potassium channel blocker and an orphan drug. It is an aromatic amine and an aminopyridine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ccncc1 |
Identifiers
| PDB | — |
| CAS-ID | 504-24-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL284348 |
| ChEBI ID | 34385 |
| PubChem CID | 1727 |
| DrugBank | DB06637 |
| UNII ID | BH3B64OKL9 (ChemIDplus, GSRS) |
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Ampyra – Acorda Therapeutics
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Ampyra – Alkermes
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Ampyra – Elan Corporation
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Ampyra – Biogen
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Fampyra – Biogen
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Tabular view
Estimated US medical usage
Dalfampridine
Total medical expenditures per year (USD, in millions)
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Trends
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Additional graphs summarizing 3,173 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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66,308 adverse events reported
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