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Drug ReportsDalfampridine
Ampyra, Fampyra(dalfampridine)
Ampyra, Dalfampridine (dalfampridine) is a small molecule pharmaceutical. Dalfampridine was first approved as Ampyra on 2010-01-22. It is used to treat multiple sclerosis and neurologic gait disorders in the USA.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Ampyra, Dalfampridine (discontinued: Dalfampridine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Dalfampridine
Tradename
Company
Number
Date
Products
AMPYRAMerzN-022250 RX2010-01-22
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
ampyraNew Drug Application2025-05-05
dalfampridineANDA2025-02-12
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
N07: Other nervous system drugs in atc
N07X: Other nervous system drugs in atc
N07XX: Other nervous system drugs in atc
N07XX07: Fampridine
HCPCS
No data
Clinical
Clinical Trials
190 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G3513329
SclerosisD0125981337
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Relapsing-remitting multiple sclerosisD020529EFO_000392911
Chronic progressive multiple sclerosisD020528EFO_000384011
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients11
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PregnancyD011247EFO_0002950Z33.111
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDalfampridine
INNfampridine
Description
4-aminopyridine is an aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis. It has a role as an avicide, a potassium channel blocker and an orphan drug. It is an aromatic amine and an aminopyridine.
Classification
Small molecule
Drug class
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Structure (InChI/SMILES or Protein Sequence)
Nc1ccncc1
Identifiers
PDB
CAS-ID504-24-5
RxCUI
ChEMBL IDCHEMBL284348
ChEBI ID34385
PubChem CID1727
DrugBankDB06637
UNII IDBH3B64OKL9 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
£
Fampyra Biogen
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Ampyra Acorda Therapeutics
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Ampyra Alkermes
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Ampyra Elan Corporation
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Ampyra Biogen
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Tabular view
Estimated US medical usage
Dalfampridine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,089 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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66,107 adverse events reported
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