Dactinomycin
Dactinomycin (dactinomycin) is a protein pharmaceutical. Dactinomycin was first approved as Cosmegen on 1982-01-01. It is used to treat choriocarcinoma, ewing sarcoma, gestational trophoblastic disease, kaposi sarcoma, and melanoma amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Dactinomycin (discontinued: Cosmegen, Dactinomycin)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| dactinomycin | ANDA | 2024-06-18 |
Indications
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J9120 | Injection, dactinomycin, 0.5 mg |
Clinical
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Drug
General
| Drug common name | Dactinomycin |
| INN | dactinomycin |
| Description | 2-amino-4,6-dimethyl-3-oxo-N1,N9-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide is a cyclodepsipeptide. |
| Classification | Protein |
| Drug class | antibiotics (Streptomyces strain) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O |
Identifiers
| PDB | — |
| CAS-ID | 50-76-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1554 |
| ChEBI ID | 27666 |
| PubChem CID | 2019 |
| DrugBank | DB00970 |
| UNII ID | 1CC1JFE158 (ChemIDplus, GSRS) |
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Dactinomycin
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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