Daklinza(daclatasvir)
Daklinza (daclatasvir) is a small molecule pharmaceutical. Daclatasvir was first approved as Daklinza on 2014-08-22. It is used to treat chronic hepatitis c and hepatitis c in the USA. It has been approved in Europe to treat chronic hepatitis c.
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Daclatasvir dihydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DAKLINZA | Bristol Myers Squibb | N-206843 DISCN | 2015-07-24 | 3 products, RLD |
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Indications
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hepatitis c | — | D006526 | B19.2 |
| chronic hepatitis c | EFO_0004220 | D019698 | B18.2 |
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Clinical
Clinical Trials
211 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 18 | 35 | 37 | 11 | 47 | 142 |
| Hepatitis | D006505 | — | K75.9 | 2 | 22 | 22 | 3 | 29 | 73 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 5 | 19 | 16 | 4 | 28 | 65 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 2 | 12 | 14 | 2 | 25 | 52 |
| Covid-19 | D000086382 | — | U07.1 | 3 | 8 | 5 | 1 | 1 | 13 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | 1 | 1 | 7 | 11 |
| Fibrosis | D005355 | — | — | — | 2 | 1 | 1 | 6 | 10 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 1 | 6 | 5 | 1 | 1 | 10 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | 1 | 2 | — | 4 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | 1 | 1 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis | D006521 | — | K73.9 | 1 | 7 | 2 | — | 10 | 18 |
| Hepacivirus | D016174 | — | — | — | 6 | 5 | — | — | 11 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 2 | 1 | — | 3 | 7 |
| Hepatitis b | D006509 | — | — | — | 2 | 3 | — | 2 | 7 |
| Infections | D007239 | EFO_0000544 | — | 1 | 5 | 1 | — | — | 7 |
| Hiv | D006678 | — | O98.7 | 1 | — | 1 | — | 1 | 3 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | 1 | — | 1 | 3 |
| Directly observed therapy | D023801 | — | — | — | 1 | 1 | — | — | 1 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 1 | 1 | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Communicable diseases | D003141 | — | — | — | 3 | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | 3 | 3 | — | — | — | 3 |
| Coinfection | D060085 | — | — | — | 1 | — | — | 1 | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 1 | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 2 | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | 1 | — | — | — | 1 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | 1 | — | — | — | 1 |
| Bronchiolitis obliterans syndrome | D000092122 | — | D89.811 | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | 5 | 8 |
| Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
| Hepatic insufficiency | D048550 | — | — | 2 | — | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | — | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | — | — | — | — | 1 |
| Camurati-engelmann syndrome | D003966 | Orphanet_1328 | Q78.3 | 1 | — | — | — | — | 1 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Liver failure | D017093 | — | K72.9 | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Virus diseases | D014777 | — | B34 | — | — | — | — | 2 | 2 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | — | — | 2 | 2 |
| Hemoglobinopathies | D006453 | — | D58.2 | — | — | — | — | 1 | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
| Retinal diseases | D012164 | — | H35.9 | — | — | — | — | 1 | 1 |
| Joint diseases | D007592 | — | M12.9 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | — | — | 1 | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | — | — | — | 1 | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Daclatasvir |
| INN | daclatasvir |
| Description | Daclatasvir is a member of the class of biphenyls that is a potent inhibitor of nonstructural protein 5A and is used (as its hydrochloride salt) for treatment of hepatitis C. It has a role as a nonstructural protein 5A inhibitor and an antiviral drug. It is a member of biphenyls, a member of imidazoles, a carbamate ester, a carboxamide and a valine derivative. It is a conjugate base of a daclatasvir(2+). |
| Classification | Small molecule |
| Drug class | antivirals: nonstructural protein 5A (NS5A) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1)C(C)C |
Identifiers
| PDB | — |
| CAS-ID | 1009119-64-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2023898 |
| ChEBI ID | 82977 |
| PubChem CID | 25154714 |
| DrugBank | DB09102 |
| UNII ID | LI2427F9CI (ChemIDplus, GSRS) |
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Daklinza – Bristol Myers Squibb
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Safety
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5,803 adverse events reported
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