Dacarbazine
Dacarbazine (dacarbazine) is a small molecule pharmaceutical. Dacarbazine was first approved as Dtic-dome on 1982-01-01. It is used to treat fibrosarcoma, hodgkin disease, islet cell carcinoma, medullary carcinoma, and melanoma amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Dacarbazine (discontinued: Dacarbazine, Dtic-dome)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aleve arthritis pain gel | ANDA | 2023-11-30 |
| amazon basic care arthritis pain | ANDA | 2024-05-17 |
| arthritis pain | ANDA | 2024-12-01 |
| arthritis pain reliever | ANDA | 2025-09-08 |
| arthritis pain relieving | ANDA | 2025-09-29 |
| arthrotec | New Drug Application | 2025-08-14 |
| aspercreme arthritis | ANDA | 2025-01-28 |
| basic care arthritis pain | ANDA | 2022-01-06 |
| berkley and jensen arthritis pain | ANDA | 2023-07-26 |
| biorepair sensitive teeth | unapproved drug other | 2017-06-13 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| neuroblastoma | EFO_0000621 | D009447 | — |
| hodgkin disease | — | D006689 | C81 |
| melanoma | — | D008545 | — |
| fibrosarcoma | — | D005354 | — |
| rhabdomyosarcoma | — | D012208 | — |
| islet cell carcinoma | — | D018273 | C25.4 |
| medullary carcinoma | — | D018276 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J9130 | Dacarbazine, 100 mg |
Clinical
Clinical Trials
1163 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 4 | 1 | — | — | 5 |
| Recurrence | D012008 | — | — | — | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | — | 3 | — | — | — | 3 |
| Gliosarcoma | D018316 | — | — | 1 | 1 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
| Leiomyosarcoma | D007890 | — | — | — | 1 | — | — | — | 1 |
| Synovial sarcoma | D013584 | — | — | — | 1 | — | — | — | 1 |
| Neurofibrosarcoma | D018319 | — | — | — | 1 | — | — | — | 1 |
| Nerve sheath neoplasms | D018317 | EFO_0000760 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | EFO_0001420 | A41.9 | 1 | — | — | — | 3 | 4 |
| Toxemia | D014115 | — | — | 1 | — | — | — | 1 | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 1 | — | — | — | — | 1 |
| Hemostatic disorders | D020141 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disseminated intravascular coagulation | D004211 | — | D65 | — | — | — | — | 2 | 2 |
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 1 | 1 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | — | 1 | 1 |
| Thromboembolism | D013923 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dacarbazine |
| INN | dacarbazine |
| Description | Dacarbazine is a monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma. It has a role as an antineoplastic agent, an alkylating agent, a prodrug and a carcinogenic agent. It is a monocarboxylic acid amide, a member of imidazoles and a triazene derivative. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)/N=N/c1[nH]cnc1C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 1185241-28-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL476 |
| ChEBI ID | — |
| PubChem CID | 2942 |
| DrugBank | DB00851 |
| UNII ID | 7GR28W0FJI (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Keveyis – Strongbridge Biopharma
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Keveyis – Xeris Biopharma Holdings
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Lidocaine – Amneal Pharmaceuticals
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Lidocaine – Amphastar Pharmaceuticals
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Arthrotec – Pfizer
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Diclofenac – Amneal Pharmaceuticals
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Diclofenac – Novartis
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Zipsor – Assertio Therapeutics
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Zipsor – Assertio Therapeutics
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Cambia – Assertio Therapeutics
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Cambia – Assertio Therapeutics
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Tabular view
Estimated US medical usage
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Trends
PubMed Central
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Additional graphs summarizing 4,707 documents
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Safety
Black-box Warning
Black-box warning for: Arthrotec, Cambia, Capsinac, Clofenax, Dacarbazine, Dicloenac sodium and misoprostol, Diclofenac, Diclofenac epolamine, Diclofenac potassium, Diclofenac potassium for oral solution, Diclofenac sodium 1.5%, Diclofenac sodium and misoprostol, Diclofenac sodium d/r, Diclofenac sodium delayed release, Diclofenac sodium diclofenac sodium, Diclofenac sodium extended-release, Diclofenac sodium gel, Diclofenac sodium misoprostol, Diclofenac sodium topical sol, Diclofenac sodium topical solution, Diclofenac sodium/misoprostol, Diclogen, Diclosaicin, Diclostream, Diclotral pak, Diclovix m, Diclozor, Dimentho, Fenovar, Flector, Flexipak, Iclofenac cp, Inflatherm, Lefluniclo, Lextol, Licart, Lixofen, Lofena, Orthaphen, Pennsaid, Profinac, Varophen, Venngel ii, Venngel one, Ziclopro, Zipsor, Zorvolex
Adverse Events
Top Adverse Reactions
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138,656 adverse events reported
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