Dacarbazine
Dacarbazine (dacarbazine) is a small molecule pharmaceutical. Dacarbazine was first approved as Dtic-dome on 1982-01-01. It is used to treat fibrosarcoma, hodgkin disease, islet cell carcinoma, medullary carcinoma, and melanoma amongst others in the USA.
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Commercial
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Dacarbazine (discontinued: Dacarbazine, Dtic-dome)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aleve arthritis pain gel | ANDA | 2023-11-30 |
| amazon basic care arthritis pain | ANDA | 2024-05-17 |
| arthritis pain | ANDA | 2024-12-01 |
| arthritis pain reliever | ANDA | 2025-06-25 |
| arthritis pain relieving | ANDA | 2023-05-15 |
| arthrotec | New Drug Application | 2024-12-02 |
| aspercreme arthritis | ANDA | 2025-01-28 |
| basic care arthritis pain | ANDA | 2022-01-06 |
| berkley and jensen arthritis pain | ANDA | 2023-07-26 |
| biorepair sensitive teeth | unapproved drug other | 2017-06-13 |
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HCPCS
Code | Description |
|---|---|
| J9130 | Dacarbazine, 100 mg |
Clinical
Clinical Trials
281 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 20 | 59 | 38 | 1 | 2 | 105 |
| Hodgkin disease | D006689 | — | C81 | 6 | 55 | 26 | 3 | 8 | 92 |
| Lymphoma | D008223 | — | C85.9 | 6 | 53 | 26 | 3 | 8 | 90 |
| Disseminated intravascular coagulation | D004211 | — | D65 | — | 2 | 4 | 1 | 10 | 17 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 4 | 2 | 1 | — | 6 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | 1 | — | 2 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | — | — | 1 | — | 1 |
| Spondylarthritis | D025241 | — | — | — | — | — | 1 | — | 1 |
| Spondylitis | D013166 | — | M46.9 | — | — | — | 1 | — | 1 |
| Axial spondyloarthritis | D000089183 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 3 | 11 | 8 | — | 1 | 20 |
| Leiomyosarcoma | D007890 | — | — | 1 | 4 | 5 | — | — | 9 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | 1 | 1 | 1 | — | 5 | 8 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | — | 6 | 2 | — | — | 7 |
| Neoplasms | D009369 | — | C80 | 3 | 3 | 1 | — | — | 6 |
| Neuroblastoma | D009447 | EFO_0000621 | — | — | 1 | 4 | — | 1 | 6 |
| Toxemia | D014115 | — | — | 1 | — | 1 | — | 4 | 6 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | — | 3 | 3 | — | — | 5 |
| Cutaneous malignant melanoma | D000096142 | — | — | — | 1 | 3 | — | — | 4 |
| Liposarcoma | D008080 | — | — | — | — | 3 | — | — | 3 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 2 | 2 | — | — | — | 3 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | 2 | — | — | 1 | 3 |
| Immunotherapy | D007167 | — | — | 1 | 2 | — | — | — | 2 |
| Osteosarcoma | D012516 | — | — | 1 | 2 | — | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 2 | — | — | — | 2 |
| Urologic neoplasms | D014571 | — | C64-C68 | — | 1 | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | 1 | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | — | 1 | — | — | — | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 1 | 1 | — | — | — | 1 |
| Thyroid diseases | D013959 | — | E00-E07 | 1 | 1 | — | — | — | 1 |
Show 13 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 1 | — | — | — | 3 | 4 |
| Hemostatic disorders | D020141 | — | — | 1 | — | — | — | 3 | 4 |
| Lung neoplasms | D008175 | — | C34.90 | 2 | — | — | — | 1 | 3 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Small cell carcinoma | D018288 | — | — | 1 | — | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | — | — | — | — | 1 |
| Carcinoid tumor | D002276 | — | D3A.00 | 1 | — | — | — | — | 1 |
| Parathyroid neoplasms | D010282 | — | — | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 3 | 3 |
| Pressure ulcer | D003668 | — | L89 | — | — | — | — | 2 | 2 |
| Shock | D012769 | — | R57.1 | — | — | — | — | 2 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | — | — | 1 | 1 |
| Hiv | D006678 | — | O98.7 | — | — | — | — | 1 | 1 |
| Contraception | D003267 | — | — | — | — | — | — | 1 | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | — | — | — | 1 | 1 |
| Snake bites | D012909 | — | T63.0 | — | — | — | — | 1 | 1 |
| Iridocorneal endothelial syndrome | D057129 | — | — | — | — | — | — | 1 | 1 |
| Placenta previa | D010923 | EFO_0007442 | O44 | — | — | — | — | 1 | 1 |
Show 22 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dacarbazine |
| INN | dacarbazine |
| Description | Dacarbazine is a monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma. It has a role as an antineoplastic agent, an alkylating agent, a prodrug and a carcinogenic agent. It is a monocarboxylic acid amide, a member of imidazoles and a triazene derivative. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)/N=N/c1[nH]cnc1C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 1185241-28-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL476 |
| ChEBI ID | — |
| PubChem CID | 2942 |
| DrugBank | DB00851 |
| UNII ID | 7GR28W0FJI (ChemIDplus, GSRS) |
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Keveyis – Strongbridge Biopharma
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Keveyis – Xeris Biopharma Holdings
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Zipsor – Assertio Therapeutics
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Zipsor – Assertio Therapeutics
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Lidocaine – Amneal Pharmaceuticals
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Lidocaine – Amphastar Pharmaceuticals
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Arthrotec – Pfizer
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Cambia – Assertio Therapeutics
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Cambia – Assertio Therapeutics
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Diclofenac – Amneal Pharmaceuticals
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Diclofenac – Novartis
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Tabular view
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Additional graphs summarizing 2,171 documents
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Safety
Black-box Warning
Black-box warning for: Arthrotec, Cambia, Capsinac, Clofenax, Dacarbazine, Dicloenac sodium and misoprostol, Diclofenac, Diclofenac epolamine, Diclofenac potassium, Diclofenac potassium for oral solution, Diclofenac sodium 1.5%, Diclofenac sodium and misoprostol, Diclofenac sodium d/r, Diclofenac sodium delayed release, Diclofenac sodium diclofenac sodium, Diclofenac sodium extended-release, Diclofenac sodium gel, Diclofenac sodium misoprostol, Diclofenac sodium topical sol, Diclofenac sodium topical solution, Diclofenac sodium/misoprostol, Diclogen, Diclosaicin, Diclostream, Diclotral pak, Diclovix m, Diclozor, Dimentho, Fenovar, Flector, Flexipak, Iclofenac cp, Inflatherm, Lefluniclo, Lextol, Licart, Lixofen, Lofena, Orthaphen, Pennsaid, Profinac, Varophen, Venngel ii, Venngel one, Ziclopro, Zipsor, Zorvolex
Adverse Events
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135,899 adverse events reported
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