Dacarbazine
Dacarbazine (dacarbazine) is a small molecule pharmaceutical. Dacarbazine was first approved as Dtic-dome on 1982-01-01. It is used to treat fibrosarcoma, hodgkin disease, islet cell carcinoma, medullary carcinoma, and melanoma amongst others in the USA.
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Commercial
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Dacarbazine (discontinued: Dacarbazine, Dtic-dome)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aleve arthritis pain gel | ANDA | 2023-11-30 |
| amazon basic care arthritis pain | ANDA | 2024-05-17 |
| arthritis pain | ANDA | 2024-12-01 |
| arthritis pain reliever | ANDA | 2025-09-08 |
| arthritis pain relieving | ANDA | 2025-09-29 |
| arthrotec | New Drug Application | 2025-08-14 |
| aspercreme arthritis | ANDA | 2025-01-28 |
| basic care arthritis pain | ANDA | 2022-01-06 |
| berkley and jensen arthritis pain | ANDA | 2023-07-26 |
| biorepair sensitive teeth | unapproved drug other | 2017-06-13 |
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HCPCS
Code | Description |
|---|---|
| J9130 | Dacarbazine, 100 mg |
Clinical
Clinical Trials
1162 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 184 | 231 | 48 | 2 | 19 | 404 |
| Glioma | D005910 | EFO_0000520 | — | 83 | 100 | 11 | 2 | 9 | 174 |
| Melanoma | D008545 | — | — | 50 | 106 | 39 | 1 | 2 | 166 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 58 | 77 | 18 | 1 | 5 | 135 |
| Central nervous system neoplasms | D016543 | — | — | 43 | 61 | 9 | 1 | 6 | 108 |
| Neoplasms | D009369 | — | C80 | 63 | 49 | 9 | 1 | — | 105 |
| Astrocytoma | D001254 | EFO_0000271 | — | 46 | 42 | 18 | 1 | 6 | 99 |
| Lymphoma | D008223 | — | C85.9 | 12 | 56 | 23 | 3 | 7 | 93 |
| Hodgkin disease | D006689 | — | C81 | 6 | 54 | 26 | 3 | 10 | 93 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 27 | 24 | 7 | 1 | 2 | 56 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gliosarcoma | D018316 | — | — | 60 | 54 | 10 | — | 1 | 105 |
| Recurrence | D012008 | — | — | 26 | 34 | 5 | — | 3 | 55 |
| Nervous system neoplasms | D009423 | — | — | 16 | 34 | 3 | — | 4 | 50 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 24 | 29 | 5 | — | 1 | 50 |
| Sarcoma | D012509 | — | — | 14 | 31 | 9 | — | 2 | 49 |
| Medulloblastoma | D008527 | — | — | 20 | 16 | 1 | — | — | 30 |
| Lung neoplasms | D008175 | — | C34.90 | 6 | 23 | 2 | — | 1 | 27 |
| Ewing sarcoma | D012512 | EFO_0000173 | — | 13 | 20 | 1 | — | — | 26 |
| Ependymoma | D004806 | — | — | 17 | 10 | 1 | — | 1 | 25 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 4 | 20 | 2 | — | 1 | 25 |
Show 43 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 6 | 14 | — | — | 1 | 18 |
| Rhabdomyosarcoma | D012208 | — | — | 12 | 14 | — | — | — | 18 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 6 | 9 | — | — | — | 12 |
| Colorectal neoplasms | D015179 | — | — | 3 | 9 | — | — | — | 11 |
| Carcinoma | D002277 | — | C80.0 | 1 | 9 | — | — | — | 10 |
| Pinealoma | D010871 | — | — | 7 | 4 | — | — | — | 10 |
| Osteosarcoma | D012516 | — | — | 8 | 7 | — | — | — | 10 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 9 | — | — | — | 9 |
| Rhabdoid tumor | D018335 | — | — | 7 | 4 | — | — | — | 9 |
| Neuroendocrine carcinoma | D018278 | — | — | — | 8 | — | — | — | 8 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Meningioma | D008579 | EFO_0003098 | D32.9 | 6 | — | — | — | — | 6 |
| Craniopharyngioma | D003397 | — | — | 5 | — | — | — | — | 5 |
| Subependymal glioma | D018315 | EFO_1001197 | — | 5 | — | — | — | — | 5 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 4 | — | — | — | — | 4 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 1 | — | — | — | 3 | 4 |
| Adamantinoma | D050398 | — | — | 3 | — | — | — | — | 3 |
| Phenylketonurias | D010661 | — | E70.0 | 3 | — | — | — | — | 3 |
| Toxemia | D014115 | — | — | 1 | — | — | — | 2 | 3 |
| Hemostatic disorders | D020141 | — | — | 1 | — | — | — | 2 | 3 |
| Carcinoid tumor | D002276 | — | D3A.00 | 2 | — | — | — | — | 2 |
Show 40 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 4 | 4 |
| Pressure ulcer | D003668 | — | L89 | — | — | — | — | 2 | 2 |
| Shock | D012769 | — | R57.1 | — | — | — | — | 2 | 2 |
| Chemoradiotherapy | D059248 | — | — | — | — | — | — | 1 | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | — | — | — | 1 | 1 |
| Hiv | D006678 | — | O98.7 | — | — | — | — | 1 | 1 |
| Contraception | D003267 | — | — | — | — | — | — | 1 | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | — | — | — | 1 | 1 |
| Snake bites | D012909 | — | T63.0 | — | — | — | — | 1 | 1 |
Show 22 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dacarbazine |
| INN | dacarbazine |
| Description | Dacarbazine is a monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma. It has a role as an antineoplastic agent, an alkylating agent, a prodrug and a carcinogenic agent. It is a monocarboxylic acid amide, a member of imidazoles and a triazene derivative. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)/N=N/c1[nH]cnc1C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 1185241-28-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL476 |
| ChEBI ID | — |
| PubChem CID | 2942 |
| DrugBank | DB00851 |
| UNII ID | 7GR28W0FJI (ChemIDplus, GSRS) |
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Lidocaine – Amphastar Pharmaceuticals
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Cambia – Assertio Therapeutics
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Arthrotec – Pfizer
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Safety
Black-box Warning
Black-box warning for: Arthrotec, Cambia, Capsinac, Clofenax, Dacarbazine, Dicloenac sodium and misoprostol, Diclofenac, Diclofenac epolamine, Diclofenac potassium, Diclofenac potassium for oral solution, Diclofenac sodium 1.5%, Diclofenac sodium and misoprostol, Diclofenac sodium d/r, Diclofenac sodium delayed release, Diclofenac sodium diclofenac sodium, Diclofenac sodium extended-release, Diclofenac sodium gel, Diclofenac sodium misoprostol, Diclofenac sodium topical sol, Diclofenac sodium topical solution, Diclofenac sodium/misoprostol, Diclogen, Diclosaicin, Diclostream, Diclotral pak, Diclovix m, Diclozor, Dimentho, Fenovar, Flector, Flexipak, Iclofenac cp, Inflatherm, Lefluniclo, Lextol, Licart, Lixofen, Lofena, Orthaphen, Pennsaid, Profinac, Varophen, Venngel ii, Venngel one, Ziclopro, Zipsor, Zorvolex
Adverse Events
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138,656 adverse events reported
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