Dacarbazine
Dacarbazine (dacarbazine) is a small molecule pharmaceutical. Dacarbazine was first approved as Dtic-dome on 1982-01-01. It is used to treat fibrosarcoma, hodgkin disease, islet cell carcinoma, medullary carcinoma, and melanoma amongst others in the USA.
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Commercial
Trade Name
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Dacarbazine (discontinued: Dacarbazine, Dtic-dome)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aleve arthritis pain gel | ANDA | 2023-11-30 |
| amazon basic care arthritis pain | ANDA | 2024-05-17 |
| arthritis pain | ANDA | 2024-03-18 |
| arthritis pain reliever | ANDA | 2024-06-14 |
| arthritis pain relieving | ANDA | 2023-05-15 |
| arthrotec | New Drug Application | 2023-08-16 |
| aspercreme arthritis | ANDA | 2023-10-11 |
| basic care arthritis pain | ANDA | 2022-01-06 |
| bentyl | New Drug Application | 2024-04-03 |
| berkley and jensen arthritis pain | ANDA | 2023-07-26 |
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Indications
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| J9130 | Dacarbazine, 100 mg |
Clinical
Clinical Trials
268 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | 20 | 58 | 36 | 1 | 3 | 103 |
| Hodgkin disease | D006689 | — | C81 | 5 | 52 | 26 | 1 | 7 | 86 |
| Lymphoma | D008223 | — | C85.9 | 5 | 50 | 26 | 1 | 7 | 84 |
| Disseminated intravascular coagulation | D004211 | HP_0005521 | D65 | — | 2 | 4 | 1 | 8 | 15 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 4 | 2 | 1 | — | 6 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | 1 | — | 1 | — | 2 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | — | — | 1 | — | 1 |
| Spondylarthritis | D025241 | — | — | — | — | — | 1 | — | 1 |
| Spondylitis | D013166 | — | M46.9 | — | — | — | 1 | — | 1 |
| Axial spondyloarthritis | D000089183 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 3 | 9 | 8 | — | 1 | 18 |
| Leiomyosarcoma | D007890 | — | — | 1 | 4 | 5 | — | — | 9 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | — | 6 | 2 | — | — | 7 |
| Neoplasms | D009369 | — | C80 | 3 | 3 | 1 | — | — | 6 |
| Neuroblastoma | D009447 | EFO_0000621 | — | — | 1 | 4 | — | 1 | 6 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | 1 | — | 3 | 5 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | — | 3 | 3 | — | — | 5 |
| Cutaneous malignant melanoma | D000096142 | — | — | — | 1 | 2 | — | — | 3 |
| Toxemia | D014115 | — | — | — | — | 1 | — | 2 | 3 |
| Liposarcoma | D008080 | — | — | — | — | 3 | — | — | 3 |
Show 11 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 2 | 2 | — | — | — | 3 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | 2 | — | — | 1 | 3 |
| Immunotherapy | D007167 | — | — | 1 | 2 | — | — | — | 2 |
| Osteosarcoma | D012516 | — | — | 1 | 2 | — | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 2 | — | — | — | 2 |
| Urologic neoplasms | D014571 | — | C64-C68 | — | 1 | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | 1 | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | — | 1 | — | — | — | 1 |
| Thyroid neoplasms | D013964 | EFO_0003841 | — | 1 | 1 | — | — | — | 1 |
| Thyroid diseases | D013959 | HP_0000820 | E00-E07 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | — | — | — | 1 | 3 |
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Small cell carcinoma | D018288 | — | — | 1 | — | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | — | — | — | — | 1 |
| Carcinoid tumor | D002276 | — | D3A.00 | 1 | — | — | — | — | 1 |
| Parathyroid neoplasms | D010282 | — | — | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | — | — | — | 1 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Septic shock | D012772 | — | A48.3 | — | — | — | — | 3 | 3 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | — | 3 | 3 |
| Hemostatic disorders | D020141 | — | — | — | — | — | — | 3 | 3 |
| Pressure ulcer | D003668 | — | — | — | — | — | — | 2 | 2 |
| Shock | D012769 | — | R57.1 | — | — | — | — | 2 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | — | — | 1 | 1 |
| Hiv | D006678 | — | — | — | — | — | — | 1 | 1 |
| Contraception | D003267 | — | — | — | — | — | — | 1 | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | — | — | — | 1 | 1 |
| Snake bites | D012909 | — | T63.0 | — | — | — | — | 1 | 1 |
Show 21 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dacarbazine |
| INN | dacarbazine |
| Description | Dacarbazine is a monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma. It has a role as an antineoplastic agent, an alkylating agent, a prodrug and a carcinogenic agent. It is a monocarboxylic acid amide, a member of imidazoles and a triazene derivative. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)/N=N/c1[nH]cnc1C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 1185241-28-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL476 |
| ChEBI ID | — |
| PubChem CID | 2942 |
| DrugBank | DB00851 |
| UNII ID | 7GR28W0FJI (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Arthrotec, Cambia, Capsinac, Cataflam, Clofenax, Dacarbazine, Dicloenac sodium and misoprostol, Diclofenac, Diclofenac epolamine, Diclofenac potassium, Diclofenac potassium for oral solution, Diclofenac sodium, Diclofenac sodium 1.5%, Diclofenac sodium and misoprostol, Diclofenac sodium d/r, Diclofenac sodium delayed release, Diclofenac sodium diclofenac sodium, Diclofenac sodium extended-release, Diclofenac sodium gel, Diclofenac sodium misoprostol, Diclofenac sodium topical sol, Diclofenac sodium topical solution, Diclofenac sodium/misoprostol, Diclogen, Diclosaicin, Diclostream, Diclotral pak, Diclovix, Diclovix cm, Diclovix m, Diclozor, Dimentho, Fenovar, Flector, Flexipak, Iclofenac cp, Inavix, Inflatherm, Lefluniclo, Lextol, Licart, Lixofen, Lofena, Pennsaid, Previdolrx analgesic pak, Previdolrx plus analgesic pak, Profinac, Solaravix, Varophen, Venngel one, Ziclopro, Zipsor, Zorvolex
Adverse Events
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120,332 adverse events reported
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