Dacarbazine
Dacarbazine (dacarbazine) is a small molecule pharmaceutical. Dacarbazine was first approved as Dtic-dome on 1982-01-01. It is used to treat fibrosarcoma, hodgkin disease, islet cell carcinoma, medullary carcinoma, and melanoma amongst others in the USA.
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Commercial
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Dacarbazine (discontinued: Dacarbazine, Dtic-dome)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aleve arthritis pain gel | ANDA | 2023-11-30 |
| amazon basic care arthritis pain | ANDA | 2024-05-17 |
| arthritis pain | ANDA | 2024-12-01 |
| arthritis pain reliever | ANDA | 2025-03-04 |
| arthritis pain relieving | ANDA | 2023-05-15 |
| arthrotec | New Drug Application | 2024-12-02 |
| aspercreme arthritis | ANDA | 2025-01-28 |
| basic care arthritis pain | ANDA | 2022-01-06 |
| berkley and jensen arthritis pain | ANDA | 2023-07-26 |
| biorepair sensitive teeth | unapproved drug other | 2017-06-13 |
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| neuroblastoma | EFO_0000621 | D009447 | — |
| hodgkin disease | — | D006689 | C81 |
| melanoma | — | D008545 | — |
| fibrosarcoma | — | D005354 | — |
| rhabdomyosarcoma | — | D012208 | — |
| islet cell carcinoma | — | D018273 | C25.4 |
| medullary carcinoma | — | D018276 | — |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J9130 | Dacarbazine, 100 mg |
Clinical
Clinical Trials
281 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | — | — | — | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
| Leiomyosarcoma | D007890 | — | — | — | 1 | — | — | — | 1 |
| Synovial sarcoma | D013584 | — | — | — | 1 | — | — | — | 1 |
| Neurofibrosarcoma | D018319 | — | — | — | 1 | — | — | — | 1 |
| Nerve sheath neoplasms | D018317 | EFO_0000760 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sepsis | D018805 | EFO_0001420 | A41.9 | 1 | — | — | — | 3 | 4 |
| Toxemia | D014115 | — | — | 1 | — | — | — | 3 | 4 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 1 | — | — | — | — | 1 |
| Hemostatic disorders | D020141 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disseminated intravascular coagulation | D004211 | — | D65 | — | — | — | — | 3 | 3 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | — | 1 | 1 |
| Thromboembolism | D013923 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dacarbazine |
| INN | dacarbazine |
| Description | Dacarbazine is a monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma. It has a role as an antineoplastic agent, an alkylating agent, a prodrug and a carcinogenic agent. It is a monocarboxylic acid amide, a member of imidazoles and a triazene derivative. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)/N=N/c1[nH]cnc1C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 1185241-28-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL476 |
| ChEBI ID | — |
| PubChem CID | 2942 |
| DrugBank | DB00851 |
| UNII ID | 7GR28W0FJI (ChemIDplus, GSRS) |
Target
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Diclofenac – Amneal Pharmaceuticals
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Cambia – Assertio Therapeutics
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Arthrotec – Pfizer
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Zipsor – Assertio Therapeutics
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Tabular view
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Additional graphs summarizing 932 documents
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Safety
Black-box Warning
Black-box warning for: Arthrotec, Cambia, Capsinac, Clofenax, Dacarbazine, Dicloenac sodium and misoprostol, Diclofenac, Diclofenac epolamine, Diclofenac potassium, Diclofenac potassium for oral solution, Diclofenac sodium, Diclofenac sodium 1.5%, Diclofenac sodium and misoprostol, Diclofenac sodium d/r, Diclofenac sodium delayed release, Diclofenac sodium diclofenac sodium, Diclofenac sodium extended-release, Diclofenac sodium gel, Diclofenac sodium misoprostol, Diclofenac sodium topical sol, Diclofenac sodium topical solution, Diclofenac sodium/misoprostol, Diclogen, Diclosaicin, Diclostream, Diclotral pak, Diclovix m, Diclozor, Dimentho, Fenovar, Flector, Flexipak, Iclofenac cp, Inflatherm, Lefluniclo, Lextol, Licart, Lixofen, Lofena, Pennsaid, Profinac, Trifena, Varophen, Venngel ii, Venngel one, Ziclopro, Zipsor, Zorvolex
Adverse Events
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135,899 adverse events reported
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