Dacarbazine
Dacarbazine (dacarbazine) is a small molecule pharmaceutical. Dacarbazine was first approved as Dtic-dome on 1982-01-01. It is used to treat fibrosarcoma, hodgkin disease, islet cell carcinoma, medullary carcinoma, and melanoma amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Dacarbazine (discontinued: Dacarbazine, Dtic-dome)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aleve arthritis pain gel | ANDA | 2023-11-30 |
| amazon basic care arthritis pain | ANDA | 2024-05-17 |
| arthritis pain | ANDA | 2024-12-01 |
| arthritis pain reliever | ANDA | 2024-12-02 |
| arthritis pain relieving | ANDA | 2023-05-15 |
| arthrotec | New Drug Application | 2024-12-02 |
| aspercreme arthritis | ANDA | 2023-10-11 |
| basic care arthritis pain | ANDA | 2022-01-06 |
| bentyl | New Drug Application | 2025-01-06 |
| berkley and jensen arthritis pain | ANDA | 2023-07-26 |
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Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9130 | Dacarbazine, 100 mg |
Clinical
No data
Drug
General
| Drug common name | Dacarbazine |
| INN | dacarbazine |
| Description | Dacarbazine is a monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma. It has a role as an antineoplastic agent, an alkylating agent, a prodrug and a carcinogenic agent. It is a monocarboxylic acid amide, a member of imidazoles and a triazene derivative. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)/N=N/c1[nH]cnc1C(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 1185241-28-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL476 |
| ChEBI ID | — |
| PubChem CID | 2942 |
| DrugBank | DB00851 |
| UNII ID | 7GR28W0FJI (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
No data
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No data
Safety
Black-box Warning
Black-box warning for: Arthrotec, Cambia, Capsinac, Cataflam, Clofenax, Dacarbazine, Dicloenac sodium and misoprostol, Diclofenac, Diclofenac epolamine, Diclofenac potassium, Diclofenac potassium for oral solution, Diclofenac sodium, Diclofenac sodium 1.5%, Diclofenac sodium and misoprostol, Diclofenac sodium d/r, Diclofenac sodium delayed release, Diclofenac sodium diclofenac sodium, Diclofenac sodium extended-release, Diclofenac sodium gel, Diclofenac sodium misoprostol, Diclofenac sodium topical sol, Diclofenac sodium topical solution, Diclofenac sodium/misoprostol, Diclogen, Diclosaicin, Diclostream, Diclotral pak, Diclovix, Diclovix cm, Diclovix m, Diclozor, Dimentho, Fenovar, Flector, Flexipak, Iclofenac cp, Inavix, Inflatherm, Lefluniclo, Lextol, Licart, Lixofen, Lofena, Pennsaid, Previdolrx analgesic pak, Previdolrx plus analgesic pak, Profinac, Solaravix, Trifena, Varophen, Venngel one, Ziclopro, Zipsor, Zorvolex
Adverse Events
0 adverse events reported
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