DRINABANT
Drinabant is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 1 | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | — | 1 |
| Dyslipidemias | D050171 | HP_0003119 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DRINABANT |
| INN | drinabant |
| Description | Drinabant (INN; AVE-1625) is a drug that acts as a selective CB1 receptor antagonist, which was under investigation varyingly by Sanofi-Aventis as a treatment for obesity, schizophrenia, Alzheimer's disease, Parkinson's disease, and nicotine dependence. Though initially studied as a potential treatment for a variety of different medical conditions, Sanofi-Aventis eventually narrowed down the therapeutic indications of the compound to just appetite suppression. Drinabant reached phase IIb clinical trials for this purpose in the treatment of obesity but was shortly thereafter discontinued, likely due to the observation of severe psychiatric side effects including anxiety, depression, and thoughts of suicide in patients treated with the now-withdrawn rimonabant, another CB1 antagonist that was also under development by Sanofi-Aventis.
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| Classification | Small molecule |
| Drug class | cannabinol derivatives: CB (e.g., CB, CB2, etc.) cannabinoid receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)N(c1cc(F)cc(F)c1)C1CN(C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 358970-97-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545166 |
| ChEBI ID | — |
| PubChem CID | 10278470 |
| DrugBank | — |
| UNII ID | 61S98RLL5I (ChemIDplus, GSRS) |
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Safety
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Adverse Events
0 adverse events reported
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