DANUGLIPRON
Danuglipron is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target glucagon-like peptide 1 receptor.
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Commercial
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Clinical
Clinical Trials
19 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 4 | 2 | — | — | — | 6 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 4 | 2 | — | — | — | 6 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 4 | 2 | — | — | — | 6 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
| Overweight | D050177 | — | E66.3 | 4 | — | — | — | — | 4 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DANUGLIPRON |
| INN | danuglipron |
| Description | Danuglipron is a small-molecule GLP-1 agonist developed by Pfizer that, in an oral formulation, is under investigation as a therapy for diabetes mellitus. Initial results from a randomized controlled trial indicate that it reduced weight and improved diabetic control. The most commonly reported adverse events were nausea, diarrhea, and vomiting.
|
| Classification | Small molecule |
| Drug class | glucagon-like peptide receptor agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N#Cc1ccc(COc2cccc(C3CCN(Cc4nc5ccc(C(=O)O)cc5n4C[C@@H]4CCO4)CC3)n2)c(F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 2230198-02-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4518483 |
| ChEBI ID | — |
| PubChem CID | 134611040 |
| DrugBank | — |
| UNII ID | DN9IUI24GP (ChemIDplus, GSRS) |
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Safety
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