Cytisinicline
Cytisinicline is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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New Drug Application (NDA)
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Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking cessation | D016540 | EFO_0004319 | — | 7 | 4 | 7 | 2 | 1 | 20 |
| Tobacco use disorder | D014029 | — | F17 | — | 1 | — | 2 | 1 | 4 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 1 | 1 | 1 | — | 2 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | 1 | 1 | 1 | — | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | 1 | — | — | 1 |
| Smoking | D012907 | EFO_0004318 | — | — | 1 | 1 | — | — | 1 |
| Addictive behavior | D016739 | EFO_0004347 | — | — | — | 1 | — | — | 1 |
| Tobacco smoking | D000073869 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 1 | — | — | 1 | 2 |
| Diet therapy | D004035 | — | — | — | 1 | — | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | — | 1 |
| Exercise | D015444 | EFO_0000483 | — | — | 1 | — | — | — | 1 |
| Vaping | D000072137 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 2 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 1 | 1 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | — | — | 1 | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 1 | 1 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cytisinicline |
| INN | cytisinicline |
| Description | Cytisine is an organic heterotricyclic compound that is the toxic principle in Laburnum seeds and is found in many members of the Fabaceae (legume, pea or bean) family. An acetylcholine agonist, it is widely used throughout Eastern Europe as an aid to giving up smoking. It has a role as a nicotinic acetylcholine receptor agonist, a phytotoxin and a plant metabolite. It is an alkaloid, an organic heterotricyclic compound, a secondary amino compound, a lactam and a bridged compound. |
| Classification | Small molecule |
| Drug class | nicotinic acetylcholine receptor partial agonists/agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1cccc2n1C[C@@H]1CNC[C@H]2C1 |
Identifiers
| PDB | — |
| CAS-ID | 485-35-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL497939 |
| ChEBI ID | 4055 |
| PubChem CID | 10235 |
| DrugBank | DB09028 |
| UNII ID | 53S5U404NU (ChemIDplus, GSRS) |
Target
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Trends
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Safety
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37 adverse events reported
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