Cyclothiazide
Anhydron, Fluidil (cyclothiazide) is a small molecule pharmaceutical. Cyclothiazide was first approved as Anhydron on 1982-01-01. It is used to treat edema, heart failure, hypertension, and nephrotic syndrome in the USA. The pharmaceutical is active against solute carrier family 12 member 3. In addition, it is known to target glutamate receptor 3, glutamate receptor 4, glutamate receptor 1, and glutamate receptor 2.
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Cyclothiazide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ANHYDRON | Eli Lilly | N-013157 DISCN | 1982-01-01 | 1 products |
| FLUIDIL | Pharmacia & Upjohn | N-018173 DISCN | 1982-01-01 | 1 products |
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Drug
General
| Drug common name | Cyclothiazide |
| INN | cyclothiazide |
| Description | Cyclothiazide is 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted at positions 3, 5 and 6 by a 2-norbornen-5-yl group, chlorine, and a sulfonamide group, respectively. A thiazide diuretic, it has been used in the management of hypertension and oedema. It has a role as a diuretic and an antihypertensive agent. |
| Classification | Small molecule |
| Drug class | diuretics (thiazide derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)c1cc2c(cc1Cl)NC(C1CC3C=CC1C3)NS2(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 2259-96-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL61593 |
| ChEBI ID | 31448 |
| PubChem CID | 2910 |
| DrugBank | DB00606 |
| UNII ID | P71U09G5BW (ChemIDplus, GSRS) |
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Alternate
GRIA2
GRIA2
Organism
Homo sapiens
Gene name
GRIA2
Gene synonyms
GLUR2
NCBI Gene ID
Protein name
glutamate receptor 2
Protein synonyms
AMPA receptor subunit GluA2, AMPA-selective glutamate receptor 2, GluA2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, glutamate receptor, ionotropic, AMPA 2
Uniprot ID
Mouse ortholog
Gria2 (14800)
glutamate receptor 2 (P23819)
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