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AboutPricing
Drug ReportsCyclobenzaprine
Cyclobenzaprine
Amrix, Cyclobenzaprine (cyclobenzaprine) is a small molecule pharmaceutical. Cyclobenzaprine was first approved as Flexeril on 1982-01-01. It is used to treat muscle cramp, muscle rigidity, muscle spasticity, myositis, and pain amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Amrix, Cyclobenzaprine (discontinued: Cyclobenzaprine, Flexeril)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cyclobenzaprine hydrochloride
Tradename
Company
Number
Date
Products
AMRIXTevaN-021777 RX2007-02-01
2 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
amrixNew Drug Application2024-04-30
cyclo/gaba 10/300 packANDA2016-06-22
cyclo/magunapproved drug other2010-03-05
cyclo/mag 10mg/200mgunapproved drug other2010-02-17
cyclobenzaprineANDA2024-08-06
cyclobenzaprine cyclobenzaprine hydrochlorideANDA2023-04-17
cyclobenzaprine hciANDA2019-04-02
cyclobenzaprine hci cyclobenzaprine hclANDA2023-06-06
cyclobenzaprine hci cyclobenzaprine hcl cyclobenzprine hclANDA2019-04-04
cyclobenzaprine hclANDA2024-12-31
Show 13 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
myositisEFO_0000783D009220G72.49
painEFO_0003843D010146R52
muscle spasticity—D009128—
muscle cramp—D009120—
spasm—D013035M62.83
tetanusEFO_0005593D013742A35
muscle rigidity—D009127—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M03: Muscle relaxants
— M03B: Muscle relaxants, centrally acting agents
— M03BX: Other centrally acting agents in atc
— M03BX08: Cyclobenzaprine
HCPCS
No data
Clinical
Clinical Trials
59 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Migraine disordersD008881EFO_0003821G43——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCyclobenzaprine
INNcyclobenzaprine
Description
Cyclobenzaprine is 5-Methylidene-5H-dibenzo[a,d]cycloheptene in which one of the hydrogens of the methylidene group is substituted by a 2-(dimethylamino)ethyl group. A centrally acting skeletal muscle relaxant, it is used as its hydrochloride salt in the symptomatic treatment of painful muscle spasm. It has a role as a muscle relaxant, a tranquilizing drug and an antidepressant. It derives from a hydride of a dibenzo[a,d][7]annulene.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCC=C1c2ccccc2C=Cc2ccccc21
Identifiers
PDB—
CAS-ID303-53-7
RxCUI—
ChEMBL IDCHEMBL669
ChEBI ID3996
PubChem CID2895
DrugBankDB00924
UNII ID69O5WQQ5TI (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Amrix – Cephalon
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Estimated US medical usage
Cyclobenzaprine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,858 documents
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Safety
Black-box Warning
Black-box warning for: Lisinopril
Adverse Events
Top Adverse Reactions
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12,282 adverse events reported
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