Cyclizine
Marezine (cyclizine) is a small molecule pharmaceutical. Cyclizine was first approved as Marezine on 1982-01-01. It is used to treat dizziness, nausea, vertigo, and vomiting in the USA. The pharmaceutical is active against histamine H1 receptor.
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Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 1 | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 1 | 1 |
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 1 | 1 |
| Vomiting | D014839 | — | R11.1 | — | — | — | — | 1 | 1 |
| Bariatric surgery | D050110 | — | — | — | — | — | — | 1 | 1 |
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Drug
General
| Drug common name | Cyclizine |
| INN | cyclizine |
| Description | Cyclizine is an N-alkylpiperazine in which one nitrogen of the piperazine ring is substituted by a methyl group, while the other is substituted by a diphenylmethyl group. It has a role as an antiemetic, a cholinergic antagonist, a central nervous system depressant, a local anaesthetic and a H1-receptor antagonist. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCN(C(c2ccccc2)c2ccccc2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 82-92-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL648 |
| ChEBI ID | 3994 |
| PubChem CID | 6726 |
| DrugBank | DB01176 |
| UNII ID | QRW9FCR9P2 (ChemIDplus, GSRS) |
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950 adverse events reported
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