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Drug ReportsCyanocobalamin
Cyanocobalamin
Berocca Pn, Cyanocobalamin, Depinar, Dicopac, Dodex, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Nascobal, Vibisone, Vitaped (cyanocobalamin) is a small molecule pharmaceutical. Cyanocobalamin was first approved as Vi-twel on 1982-01-01.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Nascobal (generic drugs available since 1982-01-01, discontinued: Berubigen, Betalin, Calomist, Cobavite, Redisol, Rubivite, Rubramin pc, Ruvite, Vi-twel)
Combinations
Infuvite (discontinued: Berocca pn, Depinar, Dicopac, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE ADULTSandozN-021163 RX2000-05-18
2 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)SandozN-021265 RX2004-01-29
1 products, RLD, RS
INFUVITE PEDIATRICSandozN-021265 RX2001-02-21
1 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 LYOPHILIZEDTeligentN-018933 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 ADULTHospiraN-008809 DISCN2004-04-22
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.C. 9+3APP PharmaceuticalsN-018440 DISCN1985-08-08
1 products
M.V.I.-12 ADULTHospiraN-008809 DISCN1985-08-08
2 products
MVC PLUSAllerganN-018439 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Tradename
Company
Number
Date
Products
M.V.I. ADULTHospiraN-021625 DISCN2004-01-30
1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)HospiraN-021643 DISCN2004-02-18
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
BEROCCA PNRocheN-006071 DISCN1985-10-10
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
Hide discontinued
Cyanocobalamin
Tradename
Company
Number
Date
Products
NASCOBALEndoN-021642 RX2005-01-31
1 products, RLD, RS
Show 8 discontinued
Cyanocobalamin
+
Cyanocobalamin co-57
+
Cyanocobalamin co-58
Tradename
Company
Number
Date
Products
DICOPAC KITGE HealthcareN-017406 DISCN1982-01-01
1 products
Hide discontinued
Cyanocobalamin
+
Tannic acid
+
Zinc acetate
Tradename
Company
Number
Date
Products
DEPINARArmour PharmaceuticalN-011208 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
adult infuvite multiple vitaminsNew Drug Application2019-05-14
adult infuvite multiple vitamins for infusion pharmacy bulkNew Drug Application2013-01-01
animi-3unapproved drug other2013-02-06
animi-3 with vitamin dunapproved drug other2011-05-23
bacminunapproved drug other2014-05-02
bal-care dhaunapproved drug other2012-05-01
bal-care dha essentialunapproved drug other2012-05-01
bp vit 3unapproved drug other2023-10-11
c-nate dhaunapproved drug other2024-01-22
centratexunapproved drug other2024-01-31
Show 85 more
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Cyanocobalamin, Nascobal, Endo Pharms Inc
72296362024-08-01DPU-817
78793492024-08-01DPU-1152
80033532024-08-01U-817
94150072024-07-28U-1896
74044892024-03-12DP
89407142024-02-26U-1152
ATC Codes
B: Blood and blood forming organ drugs
— B03: Antianemic preparations
— B03B: Vitamin b12 and folic acid
— B03BA: Vitamin b12 (cyanocobalamin and analogues)
— B03BA01: Cyanocobalamin
— B03BA02: Cyanocobalamin tannin complex
— B03BA51: Cyanocobalamin, combinations
V: Various drug classes in atc
— V09: Diagnostic radiopharmaceuticals
— V09X: Other diagnostic radiopharmaceuticals in atc
— V09XX: Various diagnostic radiopharmaceuticals
— V09XX01: Cobalt (57co) cyanocobalamine
— V09XX02: Cobalt (58co) cyanocobalamine
HCPCS
Code
Description
A9546
Cobalt co-57/58, cyanocobalamin, diagnostic, per study dose, up to 1 microcurie
A9559
Cobalt co-57 cyanocobalamin, oral, diagnostic, per study dose, up to 1 microcurie
J3420
Injection, vitamin b-12 cyanocobalamin, up to 1000 mcg
Clinical
Clinical Trials
1056 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD015179——631201—54
Vitamin b 12 deficiencyD014806EFO_0000734E53.824243545
AnemiaD000740HP_0001903D64.9—4852641
NeoplasmsD009369—C8010755328
Type 2 diabetes mellitusD003924EFO_0001360E1115411120
MalnutritionD044342EFO_0008572E40-E46—3231117
Diabetic neuropathiesD003929EFO_1000783—1243817
Septic shockD012772—A48.31862—15
LymphomaD008223—C85.921021—14
Cognitive dysfunctionD060825HP_0001268G31.8423—1713
Show 80 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C2513155—228
Non-small-cell lung carcinomaD002289——2129—324
Covid-19D000086382—U07.1223—713
Colonic neoplasmsD003110—C18149——13
AdenocarcinomaD000230——139——12
HyperhomocysteinemiaD020138———12—912
PregnancyD011247EFO_0002950Z33.11—2—710
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.0235——9
LeukemiaD007938—C95143—19
Pancreatic ductal carcinomaD021441——342——9
Show 95 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———23——1115
Breast neoplasmsD001943EFO_0003869C5034——411
AgingD000375GO_0007568R41.8112——36
Prostatic neoplasmsD011471—C6113——15
Hodgkin diseaseD006689—C8113——14
Myeloid leukemia acuteD015470—C92.031———4
Triple negative breast neoplasmsD064726——22———3
Sars-cov-2D000086402——22——13
Chronic painD059350HP_0012532——2——13
SarcomaD012509——12———3
Show 80 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InflammationD007249MP_0001845—1———89
HypertensionD006973EFO_0000537I101———45
Carpal tunnel syndromeD002349EFO_0004143G56.01———45
Heart failureD006333HP_0001635I501———23
Renal cell carcinomaD002292EFO_0000376—2————2
T-cell lymphoma cutaneousD016410—C84.A2————2
Multiple sclerosisD009103EFO_0003885G351———12
Birth weightD001724EFO_0004344—1———12
Sickle cell anemiaD000755EFO_0000697D571———12
Inflammatory bowel diseasesD015212EFO_0003767—1———12
Show 13 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Gyrate atrophyD015799——————44
Folic acid deficiencyD005494EFO_0001070E53.8————44
Weight lossD015431HP_0001824—————33
Child developmentD002657——————33
Drug-related side effects and adverse reactionsD064420—T88.7————22
Vascular dementiaD015140—F01————22
Diet therapyD004035——————22
Diabetes complicationsD048909——————22
DeliriumD003693—R41.0————22
Knee osteoarthritisD020370EFO_0004616M17————22
Show 132 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCyanocobalamin
INNcyanocobalamin
Description
Cyanocobalamin is a form of vitamin B12 used to treat vitamin B12 deficiency except in the presence of cyanide toxicity. The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. It is less preferred than hydroxocobalamin for treating vitamin B12 deficiency. Some study have shown that it has an antihypotensive effect. It is used by mouth, by injection into a muscle, or as a nasal spray.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID68-19-9
RxCUI—
ChEMBL IDCHEMBL2110563
ChEBI ID—
PubChem CID16212801
DrugBankDB00115
UNII IDP6YC3EG204 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Cyanocobalamin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 68,390 documents
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Safety
Black-box Warning
Black-box warning for: Chromagen, Citranatal bloom, Ferralet 90, Hematogen fa, Hematogen forte, Marnatal f, Moms choice rx, Natafort, Neonatal fe, Neonatal19, Nestabs, Nestabs dha, Nestabs one, Niferex, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-dha, Pnv-omega, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenate am, Prenate dha, Prenate elite, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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3,549 adverse events reported
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