Cyanocobalamin - PharmaKB

Cyanocobalamin

Berocca Pn, Cyanocobalamin, Depinar, Dicopac, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vibisone, Vitaped (cyanocobalamin) is a small molecule pharmaceutical. Cyanocobalamin was first approved as Vi-twel on 1982-01-01.

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Commercial

Clinical

Drug

Target

Variants

Financial

Trends

Safety

Events Timeline

YTD

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Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

Start date

Primary completion date

Completion date

Results first post date

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Commercial

Therapeutic Areas

No data

Trade Name

FDA

EMA

Cyanocobalamin, Vibisone (discontinued: Berubigen, Betalin, Calomist, Cobavite, Cyanocobalamin, Dodex, Nascobal, Redisol, Rubivite, Rubramin pc, Ruvite, Vi-twel, Vibisone)

Combinations

Infuvite (discontinued: Berocca pn, Depinar, Dicopac, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a palmitate

Vitamin e

Tradename	Company	Number	Date	Products
BEROCCA PN	Roche	N-006071 DISCN	1985-10-10	1 products

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Alpha-tocopherol acetate

Ascorbic acid

Biotin

Cholecalciferol

Cyanocobalamin

Dexpanthenol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a palmitate

Vitamin k

Tradename	Company	Number	Date	Products
INFUVITE ADULT	Sandoz	N-021163 RX	2000-05-18	2 products, RLD, RS

Ascorbic acid

Biotin

Cholecalciferol

Cyanocobalamin

Dexpanthenol

Folic acid

Niacinamide

Pyridoxine

Riboflavin

Thiamine

Tocopherol acetate

Vitamin a

Vitamin k

Tradename	Company	Number	Date	Products
INFUVITE PEDIATRIC	Sandoz	N-021265 RX	2001-02-21	1 products, RLD, RS
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)	Sandoz	N-021265 RX	2004-01-29	1 products, RLD, RS

Cyanocobalamin

Tradename	Company	Number	Date	Products
VI-TWEL	Bayer	N-007012 DISCN	1982-01-01	1 products
RUBIVITE	Bel-Mar Laboratories	N-010791 DISCN	1982-01-01	5 products
RUBRAMIN PC	Bristol Myers Squibb	N-006799 DISCN	1982-01-01	3 products, RLD
CALOMIST	Endo	N-022102 DISCN	2007-07-27	1 products
NASCOBAL	Endo	N-019722 DISCN	1996-11-05	1 products
NASCOBAL	Endo	N-021642 DISCN	2005-01-31	1 products, RLD
REDISOL	Merck & Co	N-006668 DISCN	1982-01-01	1 products
BERUBIGEN	Pharmacia & Upjohn	N-006798 DISCN	1982-01-01	1 products
CYANOCOBALAMIN	Warner Chilcott	N-007085 DISCN	1982-01-01	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.C. 9+3	APP Pharmaceuticals	N-018440 DISCN	1985-08-08	1 products
M.V.I.-12 ADULT	Hospira	N-008809 DISCN	1985-08-08	2 products
MVC PLUS	Allergan	N-018439 DISCN	1985-08-08	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I.-12 ADULT	Hospira	N-008809 DISCN	2004-04-22	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Phytonadione

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I. PEDIATRIC	Hospira	N-018920 DISCN	2000-09-21	1 products, RLD

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Vitamin k

Tradename	Company	Number	Date	Products
M.V.I. ADULT	Hospira	N-021625 DISCN	2004-01-30	1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)	Hospira	N-021643 DISCN	2004-02-18	1 products, RLD

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Ascorbic acid

Biotin

Cyanocobalamin

Ergocalciferol

Folic acid

Niacinamide

Pantothenic acid

Phytonadione

Pyridoxine

Riboflavin

Thiamine

Vitamin a palmitate

Vitamin e

Tradename	Company	Number	Date	Products
VITAPED	Hospira	N-020176 DISCN	1993-12-29	1 products

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Cyanocobalamin

Cyanocobalamin co-57

Cyanocobalamin co-58

Tradename	Company	Number	Date	Products
DICOPAC KIT	GE Healthcare	N-017406 DISCN	1982-01-01	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine

Riboflavin 5'-phosphate sodium

Thiamine

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I.-12 LYOPHILIZED	Teligent	N-018933 DISCN	1985-08-08	1 products

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Cyanocobalamin

Tannic acid

Zinc acetate

Tradename	Company	Number	Date	Products
DEPINAR	Armour Pharmaceutical	N-011208 DISCN	1982-01-01	1 products

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Labels

FDA

EMA

Brand Name	Status	Last Update
animi-3	unapproved drug other	2013-02-06
bal-care dha	unapproved drug other	2012-05-01
bal-care dha essential	unapproved drug other	2012-05-01
bp vit 3	unapproved drug other	2025-02-13
c-nate dha	unapproved drug other	2024-01-22
centratex	unapproved drug other	2024-01-31
chromagen	unapproved drug other	2025-04-10
citranatal bloom dha	unapproved drug other	2020-04-06
coco12	unapproved drug other	2021-01-11
cyanocobalamin	ANDA	2025-06-12

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Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
hypercholesterolemia	—	D006937	—
hypophosphatemia	HP_0002148	D017674	—
hypertriglyceridemia	EFO_0004211	D015228	—
peripheral vascular diseases	EFO_0003875	D016491	I73.9
dermatitis	—	D003872	L30.9
alcoholic neuropathy	EFO_1000803	D020269	G62.1
common cold	EFO_0007214	D003139	J00
seizures	—	D012640	G40.4
vitamin a deficiency	EFO_1001237	D014802	E50
hypoparathyroidism	—	D007011	E20

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Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

B: Blood and blood forming organ drugs

— B03: Antianemic preparations

— B03B: Vitamin b12 and folic acid

— B03BA: Vitamin b12 (cyanocobalamin and analogues)

— B03BA01: Cyanocobalamin

— B03BA02: Cyanocobalamin tannin complex

— B03BA51: Cyanocobalamin, combinations

V: Various drug classes in atc

— V09: Diagnostic radiopharmaceuticals

— V09X: Other diagnostic radiopharmaceuticals in atc

— V09XX: Various diagnostic radiopharmaceuticals

— V09XX01: Cobalt (57co) cyanocobalamine

— V09XX02: Cobalt (58co) cyanocobalamine

HCPCS

Code	Description
A9546	Cobalt co-57/58, cyanocobalamin, diagnostic, per study dose, up to 1 microcurie
A9559	Cobalt co-57 cyanocobalamin, oral, diagnostic, per study dose, up to 1 microcurie
J3420	Injection, vitamin b-12 cyanocobalamin, up to 1000 mcg

Clinical

Clinical Trials

1163 clinical trials

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Indications Phases 4

No data

Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Colorectal neoplasms	D015179	—	—	—	1	2	—	—	3
Colonic neoplasms	D003110	—	C18	—	—	1	—	—	1
Stomach neoplasms	D013274	EFO_0003897	C16	—	—	1	—	—	1

Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Esophageal neoplasms	D004938	—	C15	1	1	—	—	—	1
Adenocarcinoma	D000230	—	—	1	1	—	—	—	1
Rectal neoplasms	D012004	—	—	—	1	—	—	—	1

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Rheumatoid arthritis	D001172	EFO_0000685	M06.9	1	—	—	—	—	1
Arthritis	D001168	EFO_0005856	M05-M14	1	—	—	—	—	1

Indications Without Phase

No data

Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Cyanocobalamin
INN	cyanocobalamin
Description	Cyanocobalamin is a form of vitamin B12 used to treat vitamin B12 deficiency except in the presence of cyanide toxicity. The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. It is less preferred than hydroxocobalamin for treating vitamin B12 deficiency. Some study have shown that it has an antihypotensive effect. It is used by mouth, by injection into a muscle, or as a nasal spray.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	—

Identifiers

PDB	—
CAS-ID	68-19-9
RxCUI	—
ChEMBL ID	CHEMBL2110563
ChEBI ID	—
PubChem CID	16212801
DrugBank	DB00115
UNII ID	P6YC3EG204 (ChemIDplus, GSRS)

Target

No data

Variants

No data

Financial

Revenue by drug

€

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No data

Estimated US medical usage

Cyanocobalamin

Total medical expenditures per year (USD, in millions)

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Number of persons purchased

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Number of purchases

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Refill frequency

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Price per prescription (USD)

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Tabular view

Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Additional graphs summarizing 78,130 documents

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Safety

Black-box Warning

Black-box warning for: Chromagen, Ferralet 90, Hematogen fa, Hematogen forte, Marnatal f, Moms choice rx, Natafort, Nestabs one, Niferex, Pnv prenatal vitamin, Pnv-dha, Pnv-omega, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenate am, Prenate dha, Prenate elite, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha

Adverse Events

Top Adverse Reactions

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6,212 adverse events reported

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