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Drug ReportsCyanocobalamin
Cyanocobalamin
Berocca Pn, Cyanocobalamin, Depinar, Dicopac, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vibisone, Vitaped (cyanocobalamin) is a small molecule pharmaceutical. Cyanocobalamin was first approved as Vi-twel on 1982-01-01.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Cyanocobalamin, Vibisone (discontinued: Berubigen, Betalin, Calomist, Cobavite, Cyanocobalamin, Dodex, Nascobal, Redisol, Rubivite, Rubramin pc, Ruvite, Vi-twel, Vibisone)
Combinations
Infuvite (discontinued: Berocca pn, Depinar, Dicopac, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
BEROCCA PNRocheN-006071 DISCN1985-10-10
1 products
Hide discontinued
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE ADULTSandozN-021163 RX2000-05-18
2 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE PEDIATRICSandozN-021265 RX2001-02-21
1 products, RLD, RS
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)SandozN-021265 RX2004-01-29
1 products, RLD, RS
Cyanocobalamin
Tradename
Company
Number
Date
Products
VI-TWELBayerN-007012 DISCN1982-01-01
1 products
RUBIVITEBel-Mar LaboratoriesN-010791 DISCN1982-01-01
5 products
RUBRAMIN PCBristol Myers SquibbN-006799 DISCN1982-01-01
3 products, RLD
CALOMISTEndoN-022102 DISCN2007-07-27
1 products
NASCOBALEndoN-019722 DISCN1996-11-05
1 products
NASCOBALEndoN-021642 DISCN2005-01-31
1 products, RLD
REDISOLMerck & CoN-006668 DISCN1982-01-01
1 products
BERUBIGENPharmacia & UpjohnN-006798 DISCN1982-01-01
1 products
CYANOCOBALAMINWarner ChilcottN-007085 DISCN1982-01-01
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.C. 9+3APP PharmaceuticalsN-018440 DISCN1985-08-08
1 products
M.V.I.-12 ADULTHospiraN-008809 DISCN1985-08-08
2 products
MVC PLUSAllerganN-018439 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 ADULTHospiraN-008809 DISCN2004-04-22
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Tradename
Company
Number
Date
Products
M.V.I. ADULTHospiraN-021625 DISCN2004-01-30
1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)HospiraN-021643 DISCN2004-02-18
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
Hide discontinued
Cyanocobalamin
+
Cyanocobalamin co-57
+
Cyanocobalamin co-58
Tradename
Company
Number
Date
Products
DICOPAC KITGE HealthcareN-017406 DISCN1982-01-01
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 LYOPHILIZEDTeligentN-018933 DISCN1985-08-08
1 products
Hide discontinued
Cyanocobalamin
+
Tannic acid
+
Zinc acetate
Tradename
Company
Number
Date
Products
DEPINARArmour PharmaceuticalN-011208 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
adult infuvite multiple vitaminsNew Drug Application2019-05-14
animi-3unapproved drug other2013-02-06
animi-3 with vitamin dunapproved drug other2011-05-23
bacminunapproved drug other2014-05-02
bp vit 3unapproved drug other2025-02-13
c-nate dhaunapproved drug other2024-01-22
centratexunapproved drug other2024-01-31
chromagenunapproved drug other2025-04-10
coco12unapproved drug other2021-01-11
cyanocobalaminANDA2025-05-22
Show 68 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypercholesterolemia—D006937—
hypophosphatemiaHP_0002148D017674—
hypertriglyceridemiaEFO_0004211D015228—
peripheral vascular diseasesEFO_0003875D016491I73.9
dermatitis—D003872L30.9
alcoholic neuropathyEFO_1000803D020269G62.1
common coldEFO_0007214D003139J00
seizures—D012640G40.4
vitamin a deficiencyEFO_1001237D014802E50
hypoparathyroidism—D007011E20
Show 26 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B03: Antianemic preparations
— B03B: Vitamin b12 and folic acid
— B03BA: Vitamin b12 (cyanocobalamin and analogues)
— B03BA01: Cyanocobalamin
— B03BA02: Cyanocobalamin tannin complex
— B03BA51: Cyanocobalamin, combinations
V: Various drug classes in atc
— V09: Diagnostic radiopharmaceuticals
— V09X: Other diagnostic radiopharmaceuticals in atc
— V09XX: Various diagnostic radiopharmaceuticals
— V09XX01: Cobalt (57co) cyanocobalamine
— V09XX02: Cobalt (58co) cyanocobalamine
HCPCS
Code
Description
A9546
Cobalt co-57/58, cyanocobalamin, diagnostic, per study dose, up to 1 microcurie
A9559
Cobalt co-57 cyanocobalamin, oral, diagnostic, per study dose, up to 1 microcurie
J3420
Injection, vitamin b-12 cyanocobalamin, up to 1000 mcg
Clinical
No data
Drug
General
Drug common nameCyanocobalamin
INNcyanocobalamin
Description
Cyanocobalamin is a form of vitamin B12 used to treat vitamin B12 deficiency except in the presence of cyanide toxicity. The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. It is less preferred than hydroxocobalamin for treating vitamin B12 deficiency. Some study have shown that it has an antihypotensive effect. It is used by mouth, by injection into a muscle, or as a nasal spray.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID68-19-9
RxCUI—
ChEMBL IDCHEMBL2110563
ChEBI ID—
PubChem CID16212801
DrugBankDB00115
UNII IDP6YC3EG204 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Cyanocobalamin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
No data
Safety
Black-box Warning
Black-box warning for: Chromagen, Ferralet 90, Hematogen fa, Hematogen forte, Marnatal f, Moms choice rx, Natafort, Nestabs, Nestabs dha, Niferex, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-dha, Pnv-omega, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenate am, Prenate dha, Prenate elite, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
0 adverse events reported
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