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Drug ReportsCyanocobalamin
Cyanocobalamin
Berocca Pn, Cyanocobalamin, Depinar, Dicopac, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vibisone, Vitaped (cyanocobalamin) is a small molecule pharmaceutical. Cyanocobalamin was first approved as Rubivite on 1982-01-01.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Cyanocobalamin, Vibisone (discontinued: Berubigen, Betalin, Calomist, Cobavite, Cyanocobalamin, Dodex, Nascobal, Redisol, Rubivite, Rubramin pc, Ruvite, Vi-twel, Vibisone)
Combinations
Infuvite (discontinued: Berocca pn, Depinar, Dicopac, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
BEROCCA PNRocheN-006071 DISCN1985-10-10
1 products
Hide discontinued
Alpha-tocopherol acetate
+
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a palmitate
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE ADULTSandozN-021163 RX2000-05-18
2 products, RLD, RS
Ascorbic acid
+
Biotin
+
Cholecalciferol
+
Cyanocobalamin
+
Dexpanthenol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Tocopherol acetate
+
Vitamin a
+
Vitamin k
Tradename
Company
Number
Date
Products
INFUVITE PEDIATRICSandozN-021265 RX2001-02-21
1 products, RLD, RS
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)SandozN-021265 RX2004-01-29
1 products, RLD, RS
Cyanocobalamin
Tradename
Company
Number
Date
Products
VI-TWELBayerN-007012 DISCN1982-01-01
1 products
RUBIVITEBel-Mar LaboratoriesN-010791 DISCN1982-01-01
5 products
RUBRAMIN PCBristol Myers SquibbN-006799 DISCN1982-01-01
3 products, RLD
CALOMISTEndoN-022102 DISCN2007-07-27
1 products
NASCOBALEndoN-019722 DISCN1996-11-05
1 products
NASCOBALEndoN-021642 DISCN2005-01-31
1 products, RLD
REDISOLMerck & CoN-006668 DISCN1982-01-01
1 products
BERUBIGENPharmacia & UpjohnN-006798 DISCN1982-01-01
1 products
CYANOCOBALAMINWarner ChilcottN-007085 DISCN1982-01-01
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.C. 9+3APP PharmaceuticalsN-018440 DISCN1985-08-08
1 products
M.V.I.-12 ADULTHospiraN-008809 DISCN1985-08-08
2 products
MVC PLUSAllerganN-018439 DISCN1985-08-08
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 ADULTHospiraN-008809 DISCN2004-04-22
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Phytonadione
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I. PEDIATRICHospiraN-018920 DISCN2000-09-21
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine hydrochloride
+
Riboflavin 5'-phosphate sodium
+
Thiamine hydrochloride
+
Vitamin a
+
Vitamin e
+
Vitamin k
Tradename
Company
Number
Date
Products
M.V.I. ADULTHospiraN-021625 DISCN2004-01-30
1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)HospiraN-021643 DISCN2004-02-18
1 products, RLD
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pantothenic acid
+
Phytonadione
+
Pyridoxine
+
Riboflavin
+
Thiamine
+
Vitamin a palmitate
+
Vitamin e
Tradename
Company
Number
Date
Products
VITAPEDHospiraN-020176 DISCN1993-12-29
1 products
Hide discontinued
Cyanocobalamin
+
Cyanocobalamin co-57
+
Cyanocobalamin co-58
Tradename
Company
Number
Date
Products
DICOPAC KITGE HealthcareN-017406 DISCN1982-01-01
1 products
Hide discontinued
Ascorbic acid
+
Biotin
+
Cyanocobalamin
+
Dexpanthenol
+
Ergocalciferol
+
Folic acid
+
Niacinamide
+
Pyridoxine
+
Riboflavin 5'-phosphate sodium
+
Thiamine
+
Vitamin a
+
Vitamin e
Tradename
Company
Number
Date
Products
M.V.I.-12 LYOPHILIZEDTeligentN-018933 DISCN1985-08-08
1 products
Hide discontinued
Cyanocobalamin
+
Tannic acid
+
Zinc acetate
Tradename
Company
Number
Date
Products
DEPINARArmour PharmaceuticalN-011208 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
animi-3unapproved drug other2013-02-06
animi-3 with vitamin dunapproved drug other2011-05-23
bacminunapproved drug other2014-05-02
bal-care dhaunapproved drug other2012-05-01
bal-care dha essentialunapproved drug other2012-05-01
bp vit 3unapproved drug other2025-02-13
c-nate dhaunapproved drug other2024-01-22
centratexunapproved drug other2024-01-31
chromagenunapproved drug other2026-04-08
citranatal bloom dhaunapproved drug other2020-04-06
Show 69 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypercholesterolemia—D006937—
hypophosphatemiaHP_0002148D017674—
hypertriglyceridemiaEFO_0004211D015228—
peripheral vascular diseasesEFO_0003875D016491I73.9
dermatitis—D003872L30.9
alcoholic neuropathyEFO_1000803D020269G62.1
common coldEFO_0007214D003139J00
seizures—D012640G40.4
vitamin a deficiencyEFO_1001237D014802E50
hypoparathyroidism—D007011E20
Show 26 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B03: Antianemic preparations
— B03B: Vitamin b12 and folic acid
— B03BA: Vitamin b12 (cyanocobalamin and analogues)
— B03BA01: Cyanocobalamin
— B03BA02: Cyanocobalamin tannin complex
— B03BA51: Cyanocobalamin, combinations
V: Various drug classes in atc
— V09: Diagnostic radiopharmaceuticals
— V09X: Other diagnostic radiopharmaceuticals in atc
— V09XX: Various diagnostic radiopharmaceuticals
— V09XX01: Cobalt (57co) cyanocobalamine
— V09XX02: Cobalt (58co) cyanocobalamine
HCPCS
Code
Description
A9546
Cobalt co-57/58, cyanocobalamin, diagnostic, per study dose, up to 1 microcurie
A9559
Cobalt co-57 cyanocobalamin, oral, diagnostic, per study dose, up to 1 microcurie
J3420
Injection, vitamin b-12 cyanocobalamin, up to 1000 mcg
Clinical
Clinical Trials
818 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Vitamin b 12 deficiencyD014806EFO_0000734E53.824254960
AnemiaD000740EFO_0004272D64.9—4963754
MalnutritionD044342EFO_0008572E40-E46—2431725
Diabetes mellitusD003920EFO_0000400E08-E13—2231118
Cognitive dysfunctionD060825—G31.8414—11218
Iron deficienciesD000090463—E61.1—1221418
InflammationD007249MP_0001845—2——11417
HyperhomocysteinemiaD020138———1211317
Diabetic neuropathiesD003929EFO_1000783—13211016
Type 2 diabetes mellitusD003924EFO_0001360E11—3111216
Show 78 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289——11510—327
AvitaminosisD001361EFO_0005878E56.9—24—1317
Covid-19D000086382—U07.1223—915
Parkinson diseaseD010300EFO_0002508G20—11—1011
DepressionD003863—F33.9—31—811
PregnancyD011247EFO_0002950Z33.11—2—811
Lung neoplasmsD008175—C34.90192——10
Peripheral nervous system diseasesD010523—G64131—59
Autistic disorderD001321EFO_0003758F84.0—22—79
Alzheimer diseaseD000544EFO_0000249F03—11—68
Show 97 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———23——1115
RecurrenceD012008——65———9
Brain injuriesD001930—S06.921——46
FibromyalgiaD005356EFO_0005687M79.121——35
Systemic lupus erythematosusD008180EFO_0002690M32—1——34
HepatitisD006505—K75.9—3——14
Hepatitis aD006506EFO_0007305B15—3——14
Autism spectrum disorderD000067877—F84.0—1——34
Ulcerative colitisD003093EFO_0000729K5112——14
Memory disordersD008569———1——34
Show 86 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I101———45
Child developmentD002657——1———34
Heart failureD006333EFO_0003144I501———34
Colorectal neoplasmsD015179——1———23
Sezary syndromeD012751—C84.12————2
Mycosis fungoidesD009182—C84.02————2
T-cell lymphoma cutaneousD016410—C84.A2————2
Bone fracturesD050723EFO_0003931T14.81———12
Multiple sclerosisD009103EFO_0003885G351———12
Cognition disordersD003072——1———12
Show 14 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Folic acid deficiencyD005494EFO_0001070E53.8————1212
Deglutition disordersD003680—R13.1————99
Gyrate atrophyD015799——————66
Metabolic syndromeD024821EFO_0000195E88.810————66
Vitamin a deficiencyD014802EFO_1001237E50————66
Gastroesophageal refluxD005764EFO_0003948K21————66
FatigueD005221—R53.83————55
Wounds and injuriesD014947—T14.8————44
Nutritional statusD009752——————44
Metabolic diseasesD008659EFO_0000589E88.9————44
Show 247 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCyanocobalamin
INNcyanocobalamin
Description
Cyanocobalamin is a form of vitamin B12 used to treat vitamin B12 deficiency except in the presence of cyanide toxicity. The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. It is less preferred than hydroxocobalamin for treating vitamin B12 deficiency. Some study have shown that it has an antihypotensive effect. It is used by mouth, by injection into a muscle, or as a nasal spray.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID68-19-9
RxCUI—
ChEMBL IDCHEMBL2110563
ChEBI ID—
PubChem CID16212801
DrugBankDB00115
UNII IDP6YC3EG204 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Cyanocobalamin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,999 documents
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Safety
Black-box Warning
Black-box warning for: Chromagen, Ferralet 90, Hematogen fa, Hematogen forte, Marnatal f, Moms choice rx, Natafort, Nestabs, Nestabs dha, Niferex, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-dha, Pnv-omega, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenate am, Prenate dha, Prenate elite, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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6,874 adverse events reported
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