Cyanocobalamin - PharmaKB

Cyanocobalamin

Berocca Pn, Cyanocobalamin, Depinar, Dicopac, Dodex, Infuvite, M.v.c. 9+, M.v.i, M.v.i. Lyophilized, Mvc, Vibisone, Vitaped (cyanocobalamin) is a small molecule pharmaceutical. Cyanocobalamin was first approved as Vi-twel on 1982-01-01.

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Commercial

Clinical

Drug

Target

Variants

Financial

Trends

Safety

Events Timeline

YTD

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Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

Start date

Primary completion date

Completion date

Results first post date

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Commercial

Therapeutic Areas

No data

Trade Name

FDA

EMA

Cyanocobalamin, Dodex, Vibisone (discontinued: Berubigen, Betalin, Calomist, Cobavite, Cyanocobalamin, Nascobal, Redisol, Rubivite, Rubramin pc, Ruvite, Vi-twel, Vibisone)

Combinations

Infuvite (discontinued: Berocca pn, Depinar, Dicopac, M.v.c. 9+, M.v.i., M.v.i. lyophilized, Mvc, Vitaped)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a palmitate

Vitamin e

Tradename	Company	Number	Date	Products
BEROCCA PN	Roche	N-006071 DISCN	1985-10-10	1 products

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Alpha-tocopherol acetate

Ascorbic acid

Biotin

Cholecalciferol

Cyanocobalamin

Dexpanthenol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a palmitate

Vitamin k

Tradename	Company	Number	Date	Products
INFUVITE ADULT	Sandoz	N-021163 RX	2000-05-18	2 products, RLD, RS

Ascorbic acid

Biotin

Cholecalciferol

Cyanocobalamin

Dexpanthenol

Folic acid

Niacinamide

Pyridoxine

Riboflavin

Thiamine

Tocopherol acetate

Vitamin a

Vitamin k

Tradename	Company	Number	Date	Products
INFUVITE PEDIATRIC	Sandoz	N-021265 RX	2001-02-21	1 products, RLD, RS
INFUVITE PEDIATRIC (PHARMACY BULK PACKAGE)	Sandoz	N-021265 RX	2004-01-29	1 products, RLD, RS

Cyanocobalamin

Tradename	Company	Number	Date	Products
VI-TWEL	Bayer	N-007012 DISCN	1982-01-01	1 products
RUBIVITE	Bel-Mar Laboratories	N-010791 DISCN	1982-01-01	5 products
RUBRAMIN PC	Bristol Myers Squibb	N-006799 DISCN	1982-01-01	3 products, RLD
CALOMIST	Endo	N-022102 DISCN	2007-07-27	1 products
NASCOBAL	Endo	N-019722 DISCN	1996-11-05	1 products
NASCOBAL	Endo	N-021642 DISCN	2005-01-31	1 products, RLD
REDISOL	Merck & Co	N-006668 DISCN	1982-01-01	1 products
BERUBIGEN	Pharmacia & Upjohn	N-006798 DISCN	1982-01-01	1 products
CYANOCOBALAMIN	Warner Chilcott	N-007085 DISCN	1982-01-01	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.C. 9+3	APP Pharmaceuticals	N-018440 DISCN	1985-08-08	1 products
M.V.I.-12 ADULT	Hospira	N-008809 DISCN	1985-08-08	2 products
MVC PLUS	Allergan	N-018439 DISCN	1985-08-08	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I.-12 ADULT	Hospira	N-008809 DISCN	2004-04-22	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Phytonadione

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I. PEDIATRIC	Hospira	N-018920 DISCN	2000-09-21	1 products, RLD

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine hydrochloride

Riboflavin 5'-phosphate sodium

Thiamine hydrochloride

Vitamin a

Vitamin e

Vitamin k

Tradename	Company	Number	Date	Products
M.V.I. ADULT	Hospira	N-021625 DISCN	2004-01-30	1 products, RLD
M.V.I. ADULT (PHARMACY BULK PACKAGE)	Hospira	N-021643 DISCN	2004-02-18	1 products, RLD

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Ascorbic acid

Biotin

Cyanocobalamin

Ergocalciferol

Folic acid

Niacinamide

Pantothenic acid

Phytonadione

Pyridoxine

Riboflavin

Thiamine

Vitamin a palmitate

Vitamin e

Tradename	Company	Number	Date	Products
VITAPED	Hospira	N-020176 DISCN	1993-12-29	1 products

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Cyanocobalamin

Cyanocobalamin co-57

Cyanocobalamin co-58

Tradename	Company	Number	Date	Products
DICOPAC KIT	GE Healthcare	N-017406 DISCN	1982-01-01	1 products

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Ascorbic acid

Biotin

Cyanocobalamin

Dexpanthenol

Ergocalciferol

Folic acid

Niacinamide

Pyridoxine

Riboflavin 5'-phosphate sodium

Thiamine

Vitamin a

Vitamin e

Tradename	Company	Number	Date	Products
M.V.I.-12 LYOPHILIZED	Teligent	N-018933 DISCN	1985-08-08	1 products

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Cyanocobalamin

Tannic acid

Zinc acetate

Tradename	Company	Number	Date	Products
DEPINAR	Armour Pharmaceutical	N-011208 DISCN	1982-01-01	1 products

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Labels

FDA

EMA

Brand Name	Status	Last Update
adult infuvite multiple vitamins	New Drug Application	2019-05-14
adult infuvite multiple vitamins for infusion pharmacy bulk	New Drug Application	2013-01-01
animi-3	unapproved drug other	2013-02-06
animi-3 with vitamin d	unapproved drug other	2011-05-23
bacmin	unapproved drug other	2014-05-02
bal-care dha	unapproved drug other	2012-05-01
bal-care dha essential	unapproved drug other	2012-05-01
bp vit 3	unapproved drug other	2023-10-11
c-nate dha	unapproved drug other	2024-01-22
centratex	unapproved drug other	2024-01-31

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Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
hypercholesterolemia	HP_0003124	D006937	—
hypophosphatemia	HP_0002148	D017674	—
hypertriglyceridemia	EFO_0004211	D015228	—
peripheral vascular diseases	EFO_0003875	D016491	I73.9
dermatitis	HP_0011123	D003872	L30.9
alcoholic neuropathy	EFO_1000803	D020269	G62.1
common cold	EFO_0007214	D003139	J00
seizures	HP_0002069	D012640	G40.4
vitamin a deficiency	EFO_1001237	D014802	E50
hypoparathyroidism	HP_0000829	D007011	E20

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Agency Specific

FDA

EMA

No data

Patent Expiration

Patent	Expires	Flag	FDA Information
Cyanocobalamin, Nascobal, Endo Pharms Inc
7229636	2024-08-01	DP	U-817
7879349	2024-08-01	DP	U-1152
8003353	2024-08-01		U-817
9415007	2024-07-28		U-1896
7404489	2024-03-12	DP
8940714	2024-02-26		U-1152

ATC Codes

B: Blood and blood forming organ drugs

— B03: Antianemic preparations

— B03B: Vitamin b12 and folic acid

— B03BA: Vitamin b12 (cyanocobalamin and analogues)

— B03BA01: Cyanocobalamin

— B03BA02: Cyanocobalamin tannin complex

— B03BA51: Cyanocobalamin, combinations

V: Various drug classes in atc

— V09: Diagnostic radiopharmaceuticals

— V09X: Other diagnostic radiopharmaceuticals in atc

— V09XX: Various diagnostic radiopharmaceuticals

— V09XX01: Cobalt (57co) cyanocobalamine

— V09XX02: Cobalt (58co) cyanocobalamine

HCPCS

Code	Description
A9546	Cobalt co-57/58, cyanocobalamin, diagnostic, per study dose, up to 1 microcurie
A9559	Cobalt co-57 cyanocobalamin, oral, diagnostic, per study dose, up to 1 microcurie
J3420	Injection, vitamin b-12 cyanocobalamin, up to 1000 mcg

Clinical

Clinical Trials

1114 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Colorectal neoplasms	D015179	—	—	8	35	23	2	1	63
Vitamin b 12 deficiency	D014806	EFO_0000734	E53.8	2	4	2	4	45	55
Anemia	D000740	HP_0001903	D64.9	—	4	9	7	32	50
Neoplasms	D009369	—	C80	13	15	6	5	3	37
Lymphoma	D008223	—	C85.9	11	19	7	1	1	35
Syndrome	D013577	—	—	3	4	6	3	18	31
Malnutrition	D044342	EFO_0008572	E40-E46	—	3	3	4	19	27
Type 2 diabetes mellitus	D003924	EFO_0001360	E11	1	6	5	1	14	25
Iron deficiencies	D000090463	—	—	—	1	3	4	16	23
Diabetes mellitus	D003920	HP_0000819	E08-E13	1	5	6	3	9	22

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Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Adenocarcinoma	D000230	—	—	8	12	16	—	3	35
Pancreatic neoplasms	D010190	EFO_0003860	C25	13	17	6	—	1	30
Non-small-cell lung carcinoma	D002289	—	—	3	14	9	—	3	26
Lung neoplasms	D008175	HP_0100526	C34.90	—	15	6	—	3	23
Leukemia	D007938	—	C95	5	10	7	—	1	22
Colonic neoplasms	D003110	—	C18	1	5	13	—	—	18
Carcinoma	D002277	—	C80.0	5	7	6	—	1	17
Neoplasm metastasis	D009362	EFO_0009708	—	4	10	4	—	1	17
Precursor cell lymphoblastic leukemia-lymphoma	D054198	—	—	2	6	7	—	1	15
Covid-19	D000086382	—	—	2	2	3	—	8	14

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Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Healthy volunteers/patients	—	—	—	2	3	—	—	12	16
Heart failure	D006333	HP_0001635	I50	2	2	—	—	3	6
Mucositis	D052016	EFO_1001898	—	1	5	—	—	—	6
Aging	D000375	GO_0007568	R41.81	1	2	—	—	3	6
Micronutrients	D018977	—	—	—	1	—	—	5	6
Recurrence	D012008	—	—	1	2	—	—	2	5
Prostatic neoplasms	D011471	—	C61	1	3	—	—	1	5
Myeloid leukemia	D007951	—	C92	2	3	—	—	—	5
Triple negative breast neoplasms	D064726	—	—	2	3	—	—	—	4
Chronic pain	D059350	HP_0012532	—	—	2	—	—	2	4

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Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Weight loss	D015431	HP_0001824	—	1	—	—	—	4	5
Carpal tunnel syndrome	D002349	EFO_0004143	G56.0	1	—	—	—	4	5
Metabolic diseases	D008659	EFO_0000589	E88.9	1	—	—	—	3	4
Preleukemia	D011289	—	—	3	—	—	—	—	3
Sickle cell anemia	D000755	EFO_0000697	D57	1	—	—	—	2	3
T-cell lymphoma cutaneous	D016410	—	—	2	—	—	—	—	2
Multiple sclerosis	D009103	EFO_0003885	G35	1	—	—	—	1	2
Cognition disorders	D003072	—	—	1	—	—	—	1	2
Inflammatory bowel diseases	D015212	EFO_0003767	—	1	—	—	—	1	2
Intestinal diseases	D007410	HP_0002242	K63.9	1	—	—	—	1	2

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Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Folic acid deficiency	D005494	EFO_0001070	E53.8	—	—	—	—	11	11
Deglutition disorders	D003680	HP_0002015	R13.1	—	—	—	—	8	8
Gyrate atrophy	D015799	—	—	—	—	—	—	6	6
Vitamin a deficiency	D014802	EFO_1001237	E50	—	—	—	—	6	6
Gastroesophageal reflux	D005764	EFO_0003948	K21	—	—	—	—	6	6
Body weight	D001835	EFO_0004338	—	—	—	—	—	4	4
Cerebral palsy	D002547	—	G80	—	—	—	—	4	4
Cerebral small vessel diseases	D059345	—	—	—	—	—	—	4	4
Progressive bulbar palsy	D010244	EFO_0003783	G12.1	—	—	—	—	4	4
Child development	D002657	—	—	—	—	—	—	3	3

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Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Cyanocobalamin
INN	cyanocobalamin
Description	Cyanocobalamin is a form of vitamin B12 used to treat vitamin B12 deficiency except in the presence of cyanide toxicity. The deficiency may occur in pernicious anemia, following surgical removal of the stomach, with fish tapeworm, or due to bowel cancer. It is less preferred than hydroxocobalamin for treating vitamin B12 deficiency. Some study have shown that it has an antihypotensive effect. It is used by mouth, by injection into a muscle, or as a nasal spray.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	—

Identifiers

PDB	—
CAS-ID	68-19-9
RxCUI	—
ChEMBL ID	CHEMBL2110563
ChEBI ID	—
PubChem CID	16212801
DrugBank	DB00115
UNII ID	P6YC3EG204 (ChemIDplus, GSRS)

Target

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Variants

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Financial

Revenue by drug

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Estimated US medical usage

Cyanocobalamin

Total medical expenditures per year (USD, in millions)

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Number of persons purchased

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Number of purchases

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Refill frequency

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Price per prescription (USD)

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Tabular view

Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Additional graphs summarizing 72,376 documents

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Safety

Black-box Warning

Black-box warning for: Chromagen, Ferralet 90, Hematogen fa, Hematogen forte, Marnatal f, Moms choice rx, Natafort, Nestabs, Nestabs dha, Nestabs one, Niferex, O-cal prenatal vitamin, Pnv prenatal plus multivitamin, Pnv prenatal vitamin, Pnv-dha, Pnv-omega, Pnv-select, Pr natal 400, Pr natal 400 ec, Pr natal 430, Pr natal 430 ec, Pre-tabs dha, Prenata, Prenatal plus multivitamin plus dha minicaps, Prenate am, Prenate dha, Prenate elite, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Tricare prenatal, Tristart dha, Vitafol, Vitafol fe plus, Vitafol ob, Vitafol-ob plus dha

Adverse Events

Top Adverse Reactions

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5,230 adverse events reported

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