Crotamiton
Crotan, Eurax (crotamiton) is a small molecule pharmaceutical. Crotamiton was first approved as Eurax on 1982-01-01. It is used to treat pruritus and scabies in the USA. It is known to target transient receptor potential cation channel subfamily V member 4.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Eurax (discontinued: Eurax)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Crotamiton
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EURAX | Journey Medical | N-009112 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| crotan | ANDA | 2024-04-18 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
No data
Drug
General
| Drug common name | Crotamiton |
| INN | crotamiton |
| Description | Crotamiton is an enamide resulting from the formal condensation of crotonic acid with N-ethyl-2-methylaniline. A colourless or pale yellow oily liquid, it is used in the treatment of pruritus (itching) by producing a counter-irritation: as it evaporates from the skin, it produces a cooling effect that diverts attention away from the itching. It has also been used as an acaricide in the treatment of scabies, though more effective drugs are usually preferred. It has a role as an antipruritic drug and a scabicide. It is an enamide and a tertiary carboxamide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C/C=C/C(=O)N(CC)c1ccccc1C |
Identifiers
| PDB | — |
| CAS-ID | 483-63-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200709 |
| ChEBI ID | — |
| PubChem CID | 688020 |
| DrugBank | DB00265 |
| UNII ID | D6S4O4XD0H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
TRPV4
TRPV4
Organism
Homo sapiens
Gene name
TRPV4
Gene synonyms
VRL2, VROAC
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily V member 4
Protein synonyms
Osm-9-like TRP channel 4, OSM9-like transient receptor potential channel 4, osmosensitive transient receptor potential channel 4, OTRPC4, Transient receptor potential protein 12, TRP12, Vanilloid receptor-like channel 2, Vanilloid receptor-like protein 2, vanilloid receptor-related osmotically activated channel, Vanilloid receptor-related osmotically-activated channel, VR-OAC, VRL-2
Uniprot ID
Mouse ortholog
Trpv4 (63873)
transient receptor potential cation channel subfamily V member 4 (Q9ES76)
Variants
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Crotamiton
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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