Corticorelin
Corticorelin is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acthrel | Biologic Licensing Application | 2021-11-12 |
Indications
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| J0795 | Injection, corticorelin ovine triflutate, 1 microgram |
Clinical
Clinical Trials
1719 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | 93 | 141 | 94 | 101 | 454 | 847 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 67 | 112 | 79 | 74 | 368 | 671 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 111 | 49 | 51 | 49 | 176 | 420 |
| Chronic renal insufficiency | D051436 | — | N18 | 24 | 39 | 34 | 34 | 148 | 271 |
| Fatigue | D005221 | HP_0012378 | R53.83 | 8 | 37 | 19 | 3 | 108 | 167 |
| Anemia | D000740 | HP_0001903 | D64.9 | 4 | 32 | 23 | 14 | 13 | 84 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | 12 | 5 | 7 | 9 | 33 | 64 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 4 | 4 | 8 | 1 | 25 | 41 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | 4 | 3 | 4 | 31 | 41 |
| Kidney transplantation | D016030 | — | — | 4 | 4 | 3 | 3 | 24 | 38 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 6 | 14 | 11 | — | 34 | 60 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 10 | 4 | — | 35 | 49 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 6 | 7 | — | 5 | 15 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | 4 | 2 | — | 7 | 13 |
| Leukemia | D007938 | — | C95 | 1 | 5 | 1 | — | 5 | 12 |
| Thrombosis | D013927 | — | — | 1 | 2 | 2 | — | 4 | 9 |
| Fibrosis | D005355 | — | — | — | — | 1 | — | 7 | 8 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | 3 | — | 5 | 8 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | 6 | 7 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | 1 | — | 6 | 7 |
Show 77 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dialysis | D003956 | — | — | 1 | 2 | — | — | 14 | 17 |
| Colorectal neoplasms | D015179 | — | — | — | 2 | — | — | 11 | 13 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 1 | — | — | 10 | 11 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 3 | — | — | 6 | 9 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | 4 | 2 | — | — | 3 | 8 |
| Chronic disease | D002908 | — | — | — | 2 | — | — | 5 | 7 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 2 | — | — | 4 | 6 |
| Hyperplasia | D006965 | EFO_0000536 | — | 2 | 1 | — | — | 3 | 5 |
| Pure red-cell aplasia | D012010 | HP_0012410 | — | — | 1 | — | — | 4 | 5 |
| Sleep wake disorders | D012893 | — | G47 | — | 1 | — | — | 4 | 5 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 6 | 7 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | 1 | — | — | — | 6 | 7 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | — | — | 2 | 3 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 2 | — | — | — | 1 | 3 |
| Bacterial infections | D001424 | — | A49 | 2 | — | — | — | 1 | 3 |
| Dementia | D003704 | EFO_0003862 | F03 | 1 | — | — | — | 2 | 3 |
| Acute disease | D000208 | — | — | 1 | — | — | — | 2 | 3 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | 2 | 3 |
| Meningitis | D008581 | HP_0001287 | G03 | 1 | — | — | — | 2 | 3 |
| Sleep deprivation | D012892 | — | F51.12 | 2 | — | — | — | — | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Death | D003643 | PATO_0001422 | — | — | — | — | — | 8 | 8 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | — | — | — | — | 7 | 7 |
| Apnea | D001049 | HP_0002104 | R06.81 | — | — | — | — | 7 | 7 |
| Exercise | D015444 | EFO_0000483 | — | — | — | — | — | 7 | 7 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | — | 6 | 6 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | — | — | 5 | 5 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 5 | 5 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 5 | 5 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | — | — | 5 | 5 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | — | — | 4 | 4 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Corticorelin |
| INN | corticorelin |
| Description | Corticorelin (INN, trade name Xerecept) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).
|
| Classification | Protein |
| Drug class | prehormones or hormone-release stimulating peptides |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108182 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB09067 |
| UNII ID | 56X54T817Q (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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10 adverse events reported
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