Corticorelin
Corticorelin is a protein pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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FDA
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acthrel | Biologic Licensing Application | 2021-11-12 |
Indications
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Agency Specific
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| J0795 | Injection, corticorelin ovine triflutate, 1 microgram |
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pituitary diseases | D010900 | — | E23.7 | 1 | 1 | — | 1 | 1 | 4 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | 1 | 2 | 4 |
| Hypopituitarism | D007018 | EFO_0001380 | E23.0 | — | — | — | 1 | 1 | 2 |
| Esophageal motility disorders | D015154 | — | K22.4 | — | — | — | 1 | — | 1 |
| Diffuse esophageal spasm | D015155 | EFO_1001785 | K22.4 | — | — | — | 1 | — | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | 1 | — | 1 |
| Hypothalamic diseases | D007027 | — | E23.6 | — | — | — | 1 | — | 1 |
| Hemophilia b | D002836 | — | D67 | — | — | — | 1 | — | 1 |
| Diabetes insipidus | D003919 | — | E23.2 | — | — | — | 1 | — | 1 |
| Neurogenic diabetes insipidus | D020790 | HP_0000863 | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | 2 | 3 | — | — | 5 |
| Brain edema | D001929 | EFO_1000845 | G93.6 | 1 | 2 | 3 | — | — | 5 |
| Edema | D004487 | HP_0000969 | R60.9 | 1 | 1 | 2 | — | — | 4 |
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | — | — | 1 | — | 3 | 4 |
| Acth-secreting pituitary adenoma | D049913 | — | — | — | 1 | 1 | — | 1 | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 2 | — | — | 2 | 4 |
| Pituitary neoplasms | D010911 | — | — | 1 | 1 | — | — | 1 | 3 |
| Syndrome | D013577 | — | — | 2 | 1 | — | — | 1 | 3 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | 1 | 1 | — | — | 1 | 3 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 2 | — | — | — | 2 |
| Alcohol-related disorders | D019973 | — | F10 | — | 1 | — | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | 1 | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | 1 | — | — | — | 1 |
| Fatigue | D005221 | HP_0012378 | R53.83 | 1 | 1 | — | — | — | 1 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | 1 | 1 | — | — | — | 1 |
Show 4 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep deprivation | D012892 | — | F51.12 | 2 | — | — | — | — | 2 |
| Adrenal insufficiency | D000309 | — | — | 1 | — | — | — | 1 | 2 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | — | — | — | 1 | 2 |
| Adrenocortical hyperfunction | D000308 | EFO_1000797 | — | 1 | — | — | — | 1 | 2 |
| Metabolic bone diseases | D001851 | HP_0000938 | — | 1 | — | — | — | — | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | — | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | — | — | — | — | 1 |
| Congenital adrenal hyperplasia | D000312 | — | E25.0 | 1 | — | — | — | — | 1 |
| Adrenogenital syndrome | D047808 | — | E25.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | — | 2 | 2 |
| Cushing syndrome | D003480 | EFO_0003099 | E24 | — | — | — | — | 2 | 2 |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | — | — | — | — | 1 | 1 |
| Chromosome aberrations | D002869 | Orphanet_68335 | — | — | — | — | — | 1 | 1 |
| Adenoma | D000236 | — | — | — | — | — | — | 1 | 1 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | — | — | 1 | 1 |
| Recurrence | D012008 | — | — | — | — | — | — | 1 | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | — | 1 | 1 |
| Addictive behavior | D016739 | EFO_0004347 | — | — | — | — | — | 1 | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Corticorelin |
| INN | corticorelin |
| Description | Corticorelin (INN, trade name Xerecept) is a diagnostic agent. It is a synthetic form of human corticotropin-releasing hormone (hCRH).
|
| Classification | Protein |
| Drug class | prehormones or hormone-release stimulating peptides |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108182 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB09067 |
| UNII ID | 56X54T817Q (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
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Safety
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Adverse Events
Top Adverse Reactions
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10 adverse events reported
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