Chlorhexidine gluconate
Avagard, Bioscrub, Chg, Chloraprep, Chloraprep One-step, Chloraprep Swabstick, Chlorhexidine, Cida-stat, Exidine, Hibiclens, Hibistat, Peridex, Periogard, Prevantics, Prevantics Swabstick, Soluprep (chlorhexidine gluconate) is a small molecule pharmaceutical. Chlorhexidine gluconate was first approved as Hibiclens on 1982-01-01. It is used to treat gram-negative bacterial infections, gram-positive bacterial infections, infectious skin diseases, oral candidiasis, and periodontal diseases in the USA.
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FDA
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Brand Name | Status | Last Update |
|---|---|---|
| (qiqing) chlorhexidine gluconate alcohol disinfectant | OTC monograph not final | 2020-05-15 |
| 3m avagard | New Drug Application | 2024-08-01 |
| 3m avagard d | C200263 | 2024-08-01 |
| 3m avagard foaming instant hand antiseptic | C200263 | 2024-08-01 |
| 3m avagard foaming instant hand antiseptic | OTC monograph not final | 2011-05-19 |
| 3m soluprep s | New Drug Application | 2024-08-01 |
| acclean chlorhexidine gluconate 0.12% oral rinse | ANDA | 2023-02-28 |
| alcohol disinfectant wipes | OTC monograph not final | 2020-06-24 |
| anti mucedine feminine wash | unapproved drug other | 2021-04-20 |
| anti-bacterial gel | C200263 | 2024-05-16 |
Show 130 more
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Expiration | Code | ||
|---|---|---|---|
CHLORHEXIDINE GLUCONATE / ISOPROPYL ALCOHOL, SOLUPREP S, 3M HEALTH CARE | |||
| 2026-01-20 | M-292 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Chlorhexidine Gluconate, Chlorhexidine Gluconate, Sage Prods | |||
| 7935093 | 2027-10-02 | DP | U-1022 |
| 7427574 | 2026-04-25 | DP | |
| 7717889 | 2025-02-27 | DP | U-1022 |
| 7066916 | 2024-02-17 | U-737 | |
| Chlorhexidine Gluconate / Isopropyl Alcohol, Chloraprep One-Step, Becton Dickinson Co | |||
| 7422388 | 2027-04-25 | DP | U-1397 |
| 6991394 | 2024-01-31 | DP | |
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB03: Chlorhexidine
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA02: Chlorhexidine
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AC: Biguanides and amidines as antiseptics and disinfectants
— D08AC02: Chlorhexidine
— D08AC52: Chlorhexidine, combinations
— D09: Medicated dressings
— D09A: Medicated dressings
— D09AA: Medicated dressings with antiinfectives
— D09AA12: Chlorhexidine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AA: Antiseptic throat preparations
— R02AA05: Chlorhexidine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AX: Other antiinfectives in atc
— S01AX09: Chlorhexidine
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA09: Chlorhexidine
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA04: Chlorhexidine
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Clinical
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 6 | 11 | 27 | 35 | 85 | 159 |
| Communicable diseases | D003141 | — | — | 3 | 9 | 22 | 26 | 56 | 112 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 6 | 8 | 9 | 14 | 47 | 82 |
| Surgical wound infection | D013530 | — | — | 3 | 9 | 14 | 14 | 38 | 75 |
| Dental caries | D003731 | EFO_0003819 | K02 | 5 | 6 | 8 | 3 | 33 | 53 |
| Gingivitis | D005891 | HP_0000230 | K05.10 | 2 | 8 | 9 | 6 | 24 | 47 |
| Periodontal diseases | D010510 | — | K05.6 | 1 | 3 | 6 | 5 | 31 | 44 |
| Pneumonia | D011014 | EFO_0003106 | — | 4 | 5 | 5 | 4 | 22 | 39 |
| Sepsis | D018805 | HP_0100806 | A41.9 | 1 | 4 | 8 | 4 | 15 | 30 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | 2 | 3 | 4 | 3 | 18 | 30 |
Show 135 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Surgical wound | D000072836 | — | — | — | — | 4 | — | 8 | 12 |
| Dental pulp necrosis | D003790 | — | K04.1 | — | 2 | 1 | — | 7 | 9 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | 6 | 7 |
| Head and neck neoplasms | D006258 | — | — | 1 | 1 | 1 | — | 3 | 6 |
| Neonatal sepsis | D000071074 | HP_0040187 | — | — | 2 | 1 | — | 4 | 6 |
| Infant mortality | D007226 | — | — | — | — | 4 | — | 2 | 6 |
| Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | — | 1 | 1 | — | 3 | 5 |
| Burns | D002056 | — | T30.0 | — | 1 | 1 | — | 2 | 4 |
| Gingival hemorrhage | D005884 | HP_0000225 | — | — | — | 1 | — | 3 | 4 |
| Esophageal neoplasms | D004938 | — | C15 | — | 1 | 2 | — | 2 | 4 |
Show 40 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Halitosis | D006209 | — | R19.6 | 1 | 2 | — | — | 5 | 7 |
| Necrosis | D009336 | — | — | — | 1 | — | — | 6 | 7 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 1 | — | — | 4 | 5 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | 1 | — | — | 3 | 4 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 2 | — | — | 2 | 4 |
| Mouth neoplasms | D009062 | EFO_0003868 | C06.9 | — | 1 | — | — | 3 | 4 |
| Cesarean section | D002585 | — | — | — | 1 | — | — | 2 | 3 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 3 | — | — | — | 3 |
| Nonvital tooth | D019553 | — | — | — | 1 | — | — | 2 | 3 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | 2 | — | — | 1 | 3 |
Show 34 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | 4 | 5 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | 4 | 5 |
| Stomatognathic diseases | D009057 | — | K08.9 | 1 | — | — | — | 4 | 5 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | — | — | — | 3 | 4 |
| Atrophy | D001284 | — | — | 1 | — | — | — | 2 | 3 |
| Nerve block | D009407 | — | — | 1 | — | — | — | 1 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 1 | 2 |
| Infertility | D007246 | HP_0000789 | — | 1 | — | — | — | 1 | 2 |
| Salivation | D012472 | — | — | 1 | — | — | — | 1 | 2 |
| Sars-cov-2 | D000086402 | — | — | 1 | — | — | — | — | 1 |
Show 15 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wound healing | D014945 | GO_0042060 | — | — | — | — | — | 10 | 10 |
| Syndrome | D013577 | — | — | — | — | — | — | 7 | 7 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | — | 4 | 4 |
| Alveolar bone loss | D016301 | — | — | — | — | — | — | 4 | 4 |
| Catheters | D057785 | — | — | — | — | — | — | 4 | 4 |
| Xerostomia | D014987 | — | K11.7 | — | — | — | — | 4 | 4 |
| Birth weight | D001724 | EFO_0004344 | — | — | — | — | — | 4 | 4 |
| Conduction anesthesia | D000765 | — | — | — | — | — | — | 3 | 3 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 3 | 3 |
| Multiple drug resistance | D018432 | — | — | — | — | — | — | 3 | 3 |
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Epidemiology
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Drug
General
| Drug common name | Chlorhexidine gluconate |
| INN | chlorhexidine |
| Description | Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. It has a role as an antiinfective agent and an antibacterial agent. It is a member of biguanides and a member of monochlorobenzenes. It is functionally related to a biguanide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO |
Identifiers
| PDB | — |
| CAS-ID | 18472-51-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297088 |
| ChEBI ID | — |
| PubChem CID | 9552079 |
| DrugBank | DB00878 |
| UNII ID | R4KO0DY52L (ChemIDplus, GSRS) |
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