Chlorhexidine gluconate
Avagard, Bioscrub, Chg, Chloraprep, Chloraprep One-step, Chloraprep Swabstick, Chlorhexidine, Cida-stat, Exidine, Hibiclens, Hibistat, Peridex, Periogard, Prevantics, Prevantics Swabstick, Soluprep (chlorhexidine gluconate) is a small molecule pharmaceutical. Chlorhexidine gluconate was first approved as Hibiclens on 1982-01-01. It is used to treat gram-negative bacterial infections, gram-positive bacterial infections, infectious skin diseases, oral candidiasis, and periodontal diseases in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| (qiqing) chlorhexidine gluconate alcohol disinfectant | OTC monograph not final | 2020-05-15 |
| 3m avagard | New Drug Application | 2026-04-22 |
| 3m soluprep s | New Drug Application | 2026-04-23 |
| acclean chlorhexidine gluconate 0.12% oral rinse | ANDA | 2026-04-30 |
| antibacterial protective hand | unapproved drug other | 2013-02-01 |
| antimicrobial foam handwash | New Drug Application | 2018-08-24 |
| antimicrobial skin cleanser | New Drug Application | 2019-06-18 |
| antiseptic cleansing wipes | unapproved drug other | 2018-10-08 |
| antiseptic foam handwash | New Drug Application | 2018-08-24 |
| antiseptic skin cleanser | New Drug Application | 2026-04-29 |
Show 118 more
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
CHLORHEXIDINE GLUCONATE / ISOPROPYL ALCOHOL, SOLUPREP S, 3M HEALTH CARE | |||
| 2026-01-20 | M-292 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Chlorhexidine Gluconate, Chlorhexidine Gluconate, Sage Prods | |||
| 7935093 | 2027-10-02 | DP | U-1022 |
| 7427574 | 2026-04-25 | DP | |
| 7717889 | 2025-02-27 | DP | U-1022 |
| 7066916 | 2024-02-17 | U-737 | |
| Chlorhexidine Gluconate / Isopropyl Alcohol, Chloraprep One-Step, Becton Dickinson Co | |||
| 7422388 | 2027-04-25 | DP | U-1397 |
| 6991394 | 2024-01-31 | DP | |
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB03: Chlorhexidine
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA02: Chlorhexidine
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AC: Biguanides and amidines as antiseptics and disinfectants
— D08AC02: Chlorhexidine
— D08AC52: Chlorhexidine, combinations
— D09: Medicated dressings
— D09A: Medicated dressings
— D09AA: Medicated dressings with antiinfectives
— D09AA12: Chlorhexidine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AA: Antiseptic throat preparations
— R02AA05: Chlorhexidine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AX: Other antiinfectives in atc
— S01AX09: Chlorhexidine
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA09: Chlorhexidine
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA04: Chlorhexidine
HCPCS
No data
Clinical
Clinical Trials
1250 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 6 | 9 | 21 | 24 | 79 | 134 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 6 | 8 | 7 | 13 | 55 | 87 |
| Communicable diseases | D003141 | — | — | 3 | 5 | 15 | 18 | 47 | 85 |
| Surgical wound infection | D013530 | — | — | 3 | 9 | 14 | 15 | 44 | 82 |
| Gingivitis | D005891 | — | K05.10 | 2 | 11 | 15 | 7 | 32 | 64 |
| Periodontal diseases | D010510 | — | K05.6 | 1 | 3 | 9 | 8 | 40 | 59 |
| Dental caries | D003731 | EFO_0003819 | K02 | 6 | 6 | 8 | 3 | 30 | 51 |
| Dental plaque | D003773 | — | — | 3 | 5 | 7 | 5 | 19 | 37 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | 1 | 4 | 9 | 4 | 19 | 35 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | 2 | 3 | 4 | 3 | 22 | 34 |
Show 140 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Halitosis | D006209 | — | R19.6 | 1 | 3 | 2 | — | 7 | 11 |
| Surgical wound | D000072836 | — | — | — | — | 3 | — | 7 | 10 |
| Dental pulp necrosis | D003790 | — | K04.1 | 1 | 2 | 1 | — | 7 | 10 |
| Periapical periodontitis | D010485 | EFO_1001391 | K04.5 | — | 1 | 1 | — | 7 | 9 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | 7 | 8 |
| Neonatal sepsis | D000071074 | — | — | — | 2 | 2 | — | 5 | 8 |
| Head and neck neoplasms | D006258 | — | — | 1 | 1 | 1 | — | 3 | 6 |
| Infant mortality | D007226 | — | — | — | — | 4 | — | 2 | 6 |
| Burns | D002056 | — | T30.0 | — | 1 | 1 | — | 4 | 6 |
| Gingival hemorrhage | D005884 | — | — | — | — | 2 | — | 4 | 6 |
Show 51 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Premature birth | D047928 | EFO_0003917 | O60 | — | 1 | — | — | 6 | 7 |
| Mouth neoplasms | D009062 | EFO_0003868 | C06.9 | 1 | 1 | — | — | 3 | 5 |
| Cesarean section | D002585 | — | — | — | 1 | — | — | 3 | 4 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | 1 | — | — | 3 | 4 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 2 | — | — | 2 | 4 |
| Endometritis | D004716 | EFO_1001312 | — | 1 | 1 | — | — | 3 | 4 |
| Neuralgia | D009437 | EFO_0009430 | — | — | 1 | — | — | 2 | 3 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 3 | — | — | — | 3 |
| Nonvital tooth | D019553 | — | — | — | 1 | — | — | 2 | 3 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | — | 2 | — | — | 1 | 3 |
Show 30 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomatognathic diseases | D009057 | — | K08.9 | 1 | — | — | — | 5 | 6 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | 4 | 5 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | — | — | — | 3 | 4 |
| Atrophy | D001284 | — | — | 1 | — | — | — | 2 | 3 |
| Nerve block | D009407 | — | — | 1 | — | — | — | 1 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 1 | 2 |
| Salivation | D012472 | — | — | 1 | — | — | — | 1 | 2 |
| Sars-cov-2 | D000086402 | — | — | 1 | — | — | — | — | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | — | 1 |
| Pulmonary heart disease | D011660 | — | I27.81 | 1 | — | — | — | — | 1 |
Show 11 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wound healing | D014945 | GO_0042060 | — | — | — | — | — | 11 | 11 |
| Syndrome | D013577 | — | — | — | — | — | — | 7 | 7 |
| Alveolar bone loss | D016301 | — | — | — | — | — | — | 7 | 7 |
| Conduction anesthesia | D000765 | — | — | — | — | — | — | 5 | 5 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | — | 5 | 5 |
| Catheters | D057785 | — | — | — | — | — | — | 5 | 5 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | — | 4 | 4 |
| Xerostomia | D014987 | — | K11.7 | — | — | — | — | 4 | 4 |
| Central venous catheters | D062905 | — | — | — | — | — | — | 4 | 4 |
| Rosacea | D012393 | — | L71 | — | — | — | — | 4 | 4 |
Show 344 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Chlorhexidine gluconate |
| INN | chlorhexidine |
| Description | Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. It has a role as an antiinfective agent and an antibacterial agent. It is a member of biguanides and a member of monochlorobenzenes. It is functionally related to a biguanide. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO |
Identifiers
| PDB | — |
| CAS-ID | 18472-51-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297088 |
| ChEBI ID | — |
| PubChem CID | 9552079 |
| DrugBank | DB00878 |
| UNII ID | R4KO0DY52L (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
23 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use