Concizumab
Concizumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. It is known to target tissue factor pathway inhibitor.
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FDA approval date
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Study first post date
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Commercial
No data
Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemophilia a | D006467 | EFO_0007267 | D66 | 6 | 3 | 6 | — | 3 | 18 |
| Hemophilia b | D002836 | — | D67 | 1 | 1 | 5 | — | 1 | 8 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | 2 | 1 | — | — | — | 3 |
| Hemostatic disorders | D020141 | — | — | 2 | 1 | — | — | — | 3 |
| Hemostasis | D006487 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Concizumab |
| INN | concizumab |
| Description | Concizumab, sold under the brand name Alhemo, is a monoclonal antibody used for the treatment of hemophilia B. It is an anti-tissue factor pathway inhibitor.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297730 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12820 |
| UNII ID | 68603V9EAF (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
TFPI
TFPI
Organism
Homo sapiens
Gene name
TFPI
Gene synonyms
LACI, TFPI1
NCBI Gene ID
Protein name
tissue factor pathway inhibitor
Protein synonyms
anti-convertin, EPI, Extrinsic pathway inhibitor, LACI, Lipoprotein-associated coagulation inhibitor, tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Uniprot ID
Mouse ortholog
Tfpi (21788)
tissue factor pathway inhibitor (Q9Z2U8)
Variants
No data
Financial
No data
Trends
PubMed Central
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Additional graphs summarizing 217 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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