Colistin
Coly-mycin (colistin) is a protein pharmaceutical. Colistin was first approved as Coly-mycin s on 1982-01-01.
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Commercial
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Combinations
Coly-mycin
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| care science essential first aid | C200263 | 2024-08-29 |
| care science osha first aid | C200263 | 2024-02-05 |
| cortisporin tc | New Drug Application | 2024-08-01 |
| cortisporin-tc | New Drug Application | 2010-01-29 |
| emergency preparedness | OTC monograph final | 2010-06-02 |
| good neighbor pharmacy emergency preparedness and first aid contains 167 pieces | OTC monograph final | 2010-06-11 |
Indications
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA10: Colistin
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01X: Other antibacterials in atc
— J01XB: Polymyxins
— J01XB01: Colistin
HCPCS
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Drug
General
| Drug common name | Colistin |
| INN | colistin |
| Description | Colistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter. It comes in two forms: colistimethate sodium can be injected into a vein, injected into a muscle, or inhaled, and colistin sulfate is mainly applied to the skin or taken by mouth. Colistimethate sodium is a prodrug; it is produced by the reaction of colistin with formaldehyde and sodium bisulfite, which leads to the addition of a sulfomethyl group to the primary amines of colistin. Colistimethate sodium is less toxic than colistin when administered parenterally. In aqueous solutions it undergoes hydrolysis to form a complex mixture of partially sulfomethylated derivatives, as well as colistin. Resistance to colistin began to appear as of 2015.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O |
Identifiers
| PDB | — |
| CAS-ID | 1066-17-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2221249 |
| ChEBI ID | — |
| PubChem CID | 5311054 |
| DrugBank | DB00803 |
| UNII ID | Z67X93HJG1 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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