Colistin
Coly-mycin (colistin) is a protein pharmaceutical. Colistin was first approved as Coly-mycin s on 1982-01-01.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Combinations
Coly-mycin
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| care science essential first aid | C200263 | 2024-08-29 |
| care science osha first aid | C200263 | 2024-02-05 |
| cortisporin tc | New Drug Application | 2024-08-01 |
| cortisporin-tc | New Drug Application | 2010-01-29 |
| emergency preparedness | OTC monograph final | 2010-06-02 |
| good neighbor pharmacy emergency preparedness and first aid contains 167 pieces | OTC monograph final | 2010-06-11 |
Indications
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07A: Intestinal antiinfectives
— A07AA: Antibiotics, intestinal
— A07AA10: Colistin
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01X: Other antibacterials in atc
— J01XB: Polymyxins
— J01XB01: Colistin
HCPCS
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Clinical
Clinical Trials
106 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | — | 1 | 5 | 15 | 6 | 10 | 34 |
| Infections | D007239 | EFO_0000544 | — | 2 | 1 | 8 | 10 | 10 | 30 |
| Ventilator-associated pneumonia | D053717 | EFO_1001865 | J95.851 | — | 6 | 12 | 2 | 3 | 19 |
| Communicable diseases | D003141 | — | — | — | — | 7 | 7 | 4 | 18 |
| Sepsis | D018805 | HP_0100806 | A41.9 | 1 | 1 | 4 | 4 | 3 | 12 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | 1 | 2 | 4 | 2 | 5 | 12 |
| Bacterial infections | D001424 | — | A49 | 1 | 1 | 2 | 7 | 1 | 11 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | 1 | 3 | 4 | 1 | 10 |
| Fibrosis | D005355 | — | — | 1 | 1 | 2 | 3 | — | 7 |
| Critical illness | D016638 | — | — | 1 | — | 2 | 3 | 1 | 7 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 1 | 4 | — | 1 | 6 |
| Healthy volunteers/patients | — | — | — | 1 | — | 3 | — | — | 4 |
| Iatrogenic disease | D007049 | — | — | — | 1 | 1 | — | — | 2 |
| Bronchitis | D001991 | — | J40 | — | — | 1 | — | 1 | 2 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | 1 | — | 1 | 2 |
| Bronchiectasis | D001987 | HP_0002110 | J47 | — | — | 2 | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | 1 | 1 | — | — | 1 |
| Covid-19 | D000086382 | — | — | — | — | 1 | — | — | 1 |
| Coinfection | D060085 | — | — | — | — | 1 | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pseudomonas infections | D011552 | EFO_0001076 | A41.52 | 1 | 1 | — | — | 1 | 3 |
| Pseudomonas aeruginosa | D011550 | NCBITaxon_287 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | 1 | 2 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Pneumococcal infections | D011008 | EFO_0000772 | J13 | 1 | — | — | — | — | 1 |
| Disease resistance | D060467 | — | — | 1 | — | — | — | — | 1 |
| Gram-negative bacteria | D006090 | — | — | 1 | — | — | — | — | 1 |
| Brain diseases | D001927 | HP_0001298 | G93.40 | 1 | — | — | — | — | 1 |
| Hepatic encephalopathy | D006501 | — | K72.91 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Escherichia coli infections | D004927 | EFO_1001318 | B96.20 | — | — | — | — | 1 | 1 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | — | — | 1 | 1 |
| Klebsiella pneumoniae | D007711 | NCBITaxon_573 | — | — | — | — | — | 1 | 1 |
| Neurotoxicity syndromes | D020258 | — | G92 | — | — | — | — | 1 | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 1 | 1 |
| Toxemia | D014115 | — | — | — | — | — | — | 1 | 1 |
| Molecular diagnostic techniques | D025202 | — | — | — | — | — | — | 1 | 1 |
| Asymptomatic infections | D058345 | — | — | — | — | — | — | 1 | 1 |
| Microbial drug resistance | D004352 | — | — | — | — | — | — | 1 | 1 |
| Respiratory aspiration | D053120 | EFO_1001839 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Colistin |
| INN | colistin |
| Description | Colistin, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections including pneumonia. These may involve bacteria such as Pseudomonas aeruginosa, Klebsiella pneumoniae, or Acinetobacter. It comes in two forms: colistimethate sodium can be injected into a vein, injected into a muscle, or inhaled, and colistin sulfate is mainly applied to the skin or taken by mouth. Colistimethate sodium is a prodrug; it is produced by the reaction of colistin with formaldehyde and sodium bisulfite, which leads to the addition of a sulfomethyl group to the primary amines of colistin. Colistimethate sodium is less toxic than colistin when administered parenterally. In aqueous solutions it undergoes hydrolysis to form a complex mixture of partially sulfomethylated derivatives, as well as colistin. Resistance to colistin began to appear as of 2015.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@@H](CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)[C@@H](C)O |
Identifiers
| PDB | — |
| CAS-ID | 1066-17-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2221249 |
| ChEBI ID | — |
| PubChem CID | 5311054 |
| DrugBank | DB00803 |
| UNII ID | Z67X93HJG1 (ChemIDplus, GSRS) |
Target
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Trends
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Safety
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Adverse Events
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1,484 adverse events reported
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