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AboutPricing
Drug ReportsCocaine
Cocaine
Goprelto, Numbrino (cocaine) is a small molecule pharmaceutical. Cocaine was first approved as Goprelto on 2017-12-14. It is used to treat cough and pain in the USA. The pharmaceutical is active against sodium-dependent dopamine transporter.
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YTD
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Goprelto
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cocaine hydrochloride
Tradename
Company
Number
Date
Products
GOPRELTONoden PharmaN-209963 RX2017-12-14
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
cocaine hydrochlorideNDA authorized generic2024-01-25
cocaine hydrochloride nasalNDA authorized generic2023-09-24
gopreltoNew Drug Application2024-11-06
numbrinoNew Drug Application2026-01-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
cough—D003371R05
Agency Specific
FDA
EMA
Expiration
Code
COCAINE HYDROCHLORIDE, NUMBRINO, CODY LABS INC
2023-01-10NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Cocaine Hydrochloride, Goprelto, Genus Lifesciences
98678152037-02-07U-2225, U-2226, U-2227
100164072037-02-07U-2329
101498432037-02-07U-2478, U-2479
102319612037-02-07DP
104135052037-02-07U-2479
104207602037-02-07U-2478
108570952037-02-07U-3014
108940122037-02-07U-3014
109330602037-02-07U-3014
109738112037-02-07U-2226
109873472037-02-07U-2225
110400322037-02-07DP
ATC Codes
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BC: Esters of benzoic acid for local anesthesia
— N01BC01: Cocaine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AD: Local anesthetic throat preparations
— R02AD03: Cocaine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01H: Local anesthetics, ophthalmologic
— S01HA: Local anesthetics
— S01HA01: Cocaine
— S02: Otologicals
— S02D: Other otologicals in atc
— S02DA: Analgesics and anesthetics
— S02DA02: Cocaine
HCPCS
Code
Description
C9046
Cocaine hydrochloride nasal solution for topical administration, 1 mg
Clinical
Clinical Trials
798 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
FistulaD005402————1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCocaine
INN—
Description
Cocaine is a tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca. It has a role as a local anaesthetic, a central nervous system stimulant, a sodium channel blocker, an adrenergic uptake inhibitor, a dopamine uptake inhibitor, a serotonin uptake inhibitor, a sympathomimetic agent, a vasoconstrictor agent, a xenobiotic, an environmental contaminant, a plant metabolite and a mouse metabolite. It is a methyl ester, a benzoate ester, a tertiary amino compound and a tropane alkaloid. It is a conjugate base of a cocaine(1+).
Classification
Small molecule
Drug classlocal anesthetics
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Structure (InChI/SMILES or Protein Sequence)
COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C
Identifiers
PDB—
CAS-ID50-36-2
RxCUI—
ChEMBL IDCHEMBL370805
ChEBI ID27958
PubChem CID446220
DrugBankDB00907
UNII ID—
Target
Agency Approved
SLC6A3
SLC6A3
Organism
Homo sapiens
Gene name
SLC6A3
Gene synonyms
DAT1
NCBI Gene ID
6531
Protein name
sodium-dependent dopamine transporter
Protein synonyms
DA transporter, dopamine transporter 1, solute carrier family 6 (neurotransmitter transporter), member 3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, Solute carrier family 6 member 3
Uniprot ID
Q14996
Mouse ortholog
Slc6a3 (13162)
sodium-dependent dopamine transporter (Q9R1I2)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Cocaine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 33,122 documents
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Safety
Black-box Warning
Black-box warning for: Cocaine hydrochloride, Cocaine hydrochloride nasal, Goprelto, Numbrino
Adverse Events
Top Adverse Reactions
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18,602 adverse events reported
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