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Drug ReportsCobicistat
Stribild(cobicistat)
Cobicistat, Evotaz, Genvoya, Prezcobix, Rezolsta, Stribild, Symtuza, Tybost (cobicistat) is a small molecule pharmaceutical. Cobicistat was first approved as Stribild on 2012-08-27. It is used to treat HIV infections in the USA. It has been approved in Europe to treat HIV infections.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
urogenital diseasesD000091642
immune system diseasesD007154
Trade Name
FDA
EMA
Tybost (discontinued: Cobicistat)
Combinations
Evotaz, Genvoya, Prezcobix, Stribild, Symtuza
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cobicistat
+
Darunavir
Tradename
Company
Number
Date
Products
PREZCOBIXJohnson & JohnsonN-205395 RX2015-01-29
1 products, RLD, RS
Cobicistat
+
Darunavir
+
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename
Company
Number
Date
Products
SYMTUZAJohnson & JohnsonN-210455 RX2018-07-17
1 products, RLD, RS
Atazanavir sulfate
+
Cobicistat
Tradename
Company
Number
Date
Products
EVOTAZBristol Myers SquibbN-206353 RX2015-01-29
1 products, RLD, RS
Cobicistat
+
Elvitegravir
+
Emtricitabine
+
Tenofovir alafenamide fumarate
Tradename
Company
Number
Date
Products
GENVOYAGilead SciencesN-207561 RX2015-11-05
1 products, RLD, RS
Cobicistat
+
Elvitegravir
+
Emtricitabine
+
Tenofovir disoproxil fumarate
Tradename
Company
Number
Date
Products
STRIBILDGilead SciencesN-203100 RX2012-08-27
1 products, RLD, RS
Cobicistat
Tradename
Company
Number
Date
Products
TYBOSTGilead SciencesN-203094 RX2014-09-24
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
evotazNew Drug Application2023-05-12
genvoyaNew Drug Application2025-01-13
prezcobixNew Drug Application2024-07-23
stribildNew Drug Application2021-09-16
stribild accessExport only2021-03-29
symtuzaNew Drug Application2024-07-23
tybostNew Drug Application2021-09-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hiv infectionsEFO_0000764D015658B20
acquired immunodeficiency syndromeEFO_0000765D000163B20
chronic hepatitis bEFO_0004239D019694B18.1
hiv—D006678—
Agency Specific
FDA
EMA
Expiration
Code
COBICISTAT, TYBOST, GILEAD SCIENCES INC
2026-08-22ODE-260
Patent Expiration
Patent
Expires
Flag
FDA Information
Cobicistat / Darunavir / Emtricitabine / Tenofovir Alafenamide Fumarate, Symtuza, Janssen Prods
107865182038-07-19U-2978
87540652032-08-15DS, DPU-257, U-2352, U-2765
92967692032-08-15DS, DPU-257, U-2352, U-2765
73907912025-04-17DS, DP
Atazanavir Sulfate / Cobicistat, Evotaz, Bristol
100397182032-10-06DP
81483742029-09-03DS, DPU-1279, U-2353, U-2364, U-2365, U-2766, U-2767, U-2768, U-2939
Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Alafenamide Fumarate, Genvoya, Gilead Sciences Inc
86332192030-04-30DPU-257
98912392029-09-03DPU-257
76357042026-10-26DS, DPU-257
89811032026-10-26DS, DP
71762202026-08-27DS, DPU-257
Cobicistat / Darunavir, Prezcobix, Janssen Prods
77006452026-12-26DS, DP
85189872024-02-16DS, DP
Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Disoproxil Fumarate, Stribild, Gilead Sciences Inc
85923972024-01-13DPU-257
87162642024-01-13DPU-257
94570362024-01-13DPU-257
97441812024-01-13DPU-257
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AR: Antivirals for treatment of hiv infections, combinations
— J05AR09: Emtricitabine, tenofovir disoproxil, elvitegravir and cobicistat
— J05AR14: Darunavir and cobicistat
— J05AR15: Atazanavir and cobicistat
— J05AR18: Emtricitabine, tenofovir alafenamide, elvitegravir and cobicistat
— J05AR22: Emtricitabine, tenofovir alafenamide, darunavir and cobicistat
V: Various drug classes in atc
— V03: All other therapeutic products
— V03A: All other therapeutic products
— V03AX: Other therapeutic products in atc
— V03AX03: Cobicistat
HCPCS
No data
Clinical
Clinical Trials
165 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hiv infectionsD015658EFO_0000764B2010154122992
Acquired immunodeficiency syndromeD000163EFO_0000765B2078174637
HivD006678——82158436
InfectionsD007239EFO_0000544—3358120
Healthy volunteers/patients———14——2—16
Communicable diseasesD003141———324110
Hiv-1D015497——3—41—8
Hepatitis cD006526—B19.21—23—6
HepatitisD006505HP_0012115K75.91—1215
CoinfectionD060085———112—4
Show 33 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Immunologic deficiency syndromesD007153HP_0002721D84.91613——17
Covid-19D000086382———32—26
PneumoniaD011014EFO_0003106———1—23
Hepatitis bD006509————1—12
CoronavirusD017934————1—12
Renal insufficiencyD051437HP_0000083N19——1——1
PregnancyD011247EFO_0002950Z33.1——1——1
Pneumocystis pneumoniaD011020EFO_0007448B59——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B5421———3
Coronavirus infectionsD018352EFO_0007224B34.2—2———2
Sars-cov-2D000086402———2———2
Virus diseasesD014777—B34—1———1
Viral pneumoniaD011024EFO_0007541J12.9—1———1
Vivax malariaD016780EFO_0007445B51—1———1
Falciparum malariaD016778EFO_0007444B50—1———1
LeukemiaD007938—C9511———1
Myeloid leukemia acuteD015470—C92.011———1
Precursor cell lymphoblastic leukemia-lymphomaD054198——11———1
Show 2 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalnutritionD044342EFO_0008572E40-E464————4
TuberculosisD014376EFO_0000774A15-A191———12
Hiv-2D015498——1———12
Insulin resistanceD007333HP_0000855—2————2
PharmacokineticsD010599——2————2
Neoplasm metastasisD009362EFO_0009708—1————1
Lung neoplasmsD008175HP_0100526C34.901————1
Latent tuberculosisD055985—Z22.71————1
Long qt syndromeD008133HP_0001657I45.811————1
Pharmacological phenomenaD000069437——1————1
Show 5 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Respiratory insufficiencyD012131HP_0002093J96.9————11
DiarrheaD003967HP_0002014R19.7————11
Job syndromeD007589EFO_0003775D82.4————11
Acute kidney injuryD058186HP_0001919N17————11
Chronic hepatitis bD019694EFO_0004239B18.1————11
Drug misuseD000076064——————11
Sexually transmitted diseasesD012749—A50-A64————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCobicistat
INNcobicistat
Description
Cobicistat is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoic acid with the amino group of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate. Acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications.. It has a role as a P450 inhibitor. It is a member of 1,3-thiazoles, a member of morpholines, a member of ureas, a carbamate ester and a monocarboxylic acid amide.
Classification
Small molecule
Drug classenzyme inhibitors
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1
Identifiers
PDB—
CAS-ID1004316-88-4
RxCUI—
ChEMBL IDCHEMBL2095208
ChEBI ID72291
PubChem CID25151504
DrugBankDB09065
UNII IDLW2E03M5PG (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Genvoya – Gilead Sciences
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Stribild – Gilead Sciences
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,984 documents
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Safety
Black-box Warning
Black-box warning for: Genvoya, Stribild, Stribild access, Symtuza
Adverse Events
Top Adverse Reactions
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15,174 adverse events reported
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