Therapeutic Area | MeSH |
---|---|
infections | D007239 |
urogenital diseases | D000091642 |
immune system diseases | D007154 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
PREZCOBIX | Johnson & Johnson | N-205395 RX | 2015-01-29 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
SYMTUZA | Johnson & Johnson | N-210455 RX | 2018-07-17 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
EVOTAZ | Bristol Myers Squibb | N-206353 RX | 2015-01-29 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
GENVOYA | Gilead Sciences | N-207561 RX | 2015-11-05 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
STRIBILD | Gilead Sciences | N-203100 RX | 2012-08-27 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
TYBOST | Gilead Sciences | N-203094 RX | 2014-09-24 | 1 products, RLD, RS |
Expiration | Code | ||
---|---|---|---|
COBICISTAT, TYBOST, GILEAD SCIENCES INC | |||
2026-08-22 | ODE-260 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Cobicistat / Darunavir / Emtricitabine / Tenofovir Alafenamide Fumarate, Symtuza, Janssen Prods | |||
10786518 | 2038-07-19 | U-2978 | |
8754065 | 2032-08-15 | DS, DP | U-257, U-2352, U-2765 |
9296769 | 2032-08-15 | DS, DP | U-257, U-2352, U-2765 |
7390791 | 2025-01-07 | DS, DP | |
Atazanavir Sulfate / Cobicistat, Evotaz, Bristol | |||
10039718 | 2032-10-06 | DP | |
8148374 | 2029-09-03 | DS, DP | U-1279, U-2353, U-2364, U-2365, U-2766, U-2767, U-2768, U-2939 |
Cobicistat / Elvitegravir / Emtricitabine / Tenofovir Alafenamide Fumarate, Genvoya, Gilead Sciences Inc | |||
8633219 | 2030-04-30 | DP | U-257 |
9891239 | 2029-09-03 | DP | U-257 |
7635704 | 2026-10-26 | DS, DP | U-257 |
8981103 | 2026-10-26 | DS, DP | |
7176220 | 2026-08-27 | DS, DP | U-257 |
Cobicistat / Darunavir, Prezcobix, Janssen Prods | |||
7700645 | 2026-12-26 | DS, DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 1 | 5 | 2 | — | 8 |
Hiv-1 | D015497 | — | — | 2 | — | 2 | 1 | — | 5 |
Weight gain | D015430 | — | — | — | — | — | 1 | — | 1 |
Infections | D007239 | EFO_0000544 | — | — | — | — | 1 | — | 1 |
Hiv seropositivity | D006679 | — | — | — | — | — | 1 | — | 1 |
Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | 1 | 4 | — | — | 5 |
Immunologic deficiency syndromes | D007153 | — | D84.9 | 1 | — | 2 | — | — | 3 |
Hiv | D006678 | — | O98.7 | — | — | 1 | — | — | 1 |
Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
Malnutrition | D044342 | EFO_0008572 | E40-E46 | 2 | — | — | — | — | 2 |
Crush injuries | D000071576 | — | T14.8 | 1 | — | — | — | — | 1 |
Hiv-2 | D015498 | — | — | 1 | — | — | — | — | 1 |
Drug common name | Cobicistat |
INN | cobicistat |
Description | Cobicistat is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoic acid with the amino group of 1,3-thiazol-5-ylmethyl [(2R,5R)-5-amino-1,6-diphenylhexan-2-yl]carbamate. Acts as a pharmacoenhancer in treatment of HIV-1 by inhibiting P450 enzymes that metabolise other medications.. It has a role as a P450 inhibitor. It is a member of 1,3-thiazoles, a member of morpholines, a member of ureas, a carbamate ester and a monocarboxylic acid amide. |
Classification | Small molecule |
Drug class | enzyme inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1 |
PDB | — |
CAS-ID | 1004316-88-4 |
RxCUI | — |
ChEMBL ID | CHEMBL2095208 |
ChEBI ID | 72291 |
PubChem CID | 25151504 |
DrugBank | DB09065 |
UNII ID | LW2E03M5PG (ChemIDplus, GSRS) |