Cloxacillin
Cloxapen, Tegopen (cloxacillin) is a small molecule pharmaceutical. Cloxacillin was first approved as Tegopen on 1982-01-01. It is used to treat bacterial pneumonia, cellulitis, joint diseases, osteomyelitis, and postoperative complications amongst others in the USA.
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Cloxacillin sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TEGOPEN | Bristol Myers Squibb | N-050192 DISCN | 1982-01-01 | 1 products |
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Staphylococcal infections | D013203 | — | A49.01 | — | — | 3 | 7 | 3 | 13 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 4 | 2 | 4 | 11 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | 1 | 3 | 5 | 2 | 11 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | 2 | 1 | 3 | 1 | 7 |
| Communicable diseases | D003141 | — | — | — | — | 3 | 2 | 1 | 6 |
| Infectious skin diseases | D012874 | — | — | — | — | 3 | 2 | — | 5 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | 1 | — | 2 | — | 4 |
| Wound infection | D014946 | — | — | — | 2 | — | 2 | — | 4 |
| Abscess | D000038 | EFO_0003030 | — | — | 2 | — | 2 | — | 4 |
| Endocarditis | D004696 | EFO_0000465 | I33 | — | — | 1 | 2 | 1 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial infections | D001424 | — | A49 | 1 | — | 2 | — | 2 | 5 |
| Gram-positive bacterial infections | D016908 | — | — | — | 3 | 1 | — | — | 4 |
| Methicillin-resistant staphylococcus aureus | D055624 | — | — | — | — | 2 | — | — | 2 |
| Bacterial skin diseases | D017192 | — | — | — | 1 | 1 | — | — | 2 |
| Mastitis | D008413 | EFO_1001034 | N61 | — | 1 | 1 | — | 1 | 2 |
| Staphylococcal skin infections | D013207 | EFO_1001849 | L00 | — | — | 1 | — | — | 1 |
| Soft tissue infections | D018461 | — | — | — | — | 1 | — | — | 1 |
| Skin diseases | D012871 | — | L00-L99 | — | — | 1 | — | — | 1 |
| Disease susceptibility | D004198 | — | — | — | — | 1 | — | — | 1 |
| Staphylococcus | D013210 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Drug interactions | D004347 | — | — | 2 | — | — | — | — | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | 1 | — | — | — | — | 1 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 1 | — | — | — | — | 1 |
| Gastrointestinal microbiome | D000069196 | — | — | 1 | — | — | — | — | 1 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | — | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
| Rotator cuff injuries | D000070636 | — | M75.1 | 1 | — | — | — | — | 1 |
| Rotator cuff tear arthropathy | D000070656 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | — | — | — | — | — | 2 | 2 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 2 | 2 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | — | 2 | 2 |
| Replacement arthroplasty hip | D019644 | — | — | — | — | — | — | 2 | 2 |
| Femoral neck fractures | D005265 | EFO_1001792 | S72.00 | — | — | — | — | 1 | 1 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | — | — | 1 | 1 |
| Neutropenia | D009503 | — | D70 | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Fever | D005334 | — | R50.9 | — | — | — | — | 1 | 1 |
| Febrile neutropenia | D064147 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cloxacillin |
| INN | cloxacillin |
| Description | Cloxacillin is a semisynthetic penicillin antibiotic carrying a 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxamido group at position 6. It has a role as an antibacterial agent and an antibacterial drug. It is a semisynthetic derivative, a penicillin allergen and a penicillin. It is functionally related to an oxacillin. It is a conjugate acid of a cloxacillin(1-). |
| Classification | Small molecule |
| Drug class | penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1onc(-c2ccccc2Cl)c1C(=O)N[C@@H]1C(=O)N2[C@@H](C(=O)O)C(C)(C)S[C@H]12 |
Identifiers
| PDB | — |
| CAS-ID | 61-72-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL891 |
| ChEBI ID | 49566 |
| PubChem CID | 6098 |
| DrugBank | DB01147 |
| UNII ID | O6X5QGC2VB (ChemIDplus, GSRS) |
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Cloxacillin
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3,947 adverse events reported
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