Clotrimazole
Clotrimazole, Trivagizole (clotrimazole) is a small molecule pharmaceutical. Clotrimazole was first approved as Mycelex on 1982-01-01. It is used to treat cutaneous candidiasis, mycoses, oral candidiasis, tinea pedis, and vulvovaginal candidiasis in the USA. It is known to target transient receptor potential cation channel subfamily M member 8, intermediate conductance calcium-activated potassium channel protein 4, transient receptor potential cation channel subfamily M member 4, nuclear receptor subfamily 1 group I member 2, transient receptor potential cation channel subfamily M member 2, and nuclear receptor subfamily 1 group I member 3.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Trade Name
FDA
EMA
Clotrimazole, Trivagizole (discontinued: Gyne-lotrimin, Gynix, Lotrimin, Mycelex)
CombinationsClotrimazole betamethasone (discontinued: Lotrisone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clotrimazole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRIVAGIZOLE 3 | Taro Pharmaceutical | N-021143 OTC | 2000-04-12 | 1 products |
Show 16 discontinued
Betamethasone dipropionate
+
Clotrimazole
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOTRISONE | Merck & Co | N-020010 DISCN | 2000-12-08 | 1 products, RLD |
| LOTRISONE | Organon | N-018827 DISCN | 1984-07-10 | 1 products, RLD |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 1med clotrimazole 1% antifungal cream | OTC monograph final | 2022-02-04 |
| akin anti-fungal | C200263 | 2023-11-29 |
| alevazol | unapproved drug other | 2024-01-02 |
| anti-fungal | C200263 | 2024-05-17 |
| anti-fungal cream | OTC monograph final | 2020-01-08 |
| antifungal | C200263 | 2025-04-28 |
| antifungal 1% clotrimazole cream | C200263 | 2024-12-16 |
| antifungal cream | OTC monograph final | 2013-11-07 |
| aptrimazole | OTC monograph final | 2013-04-27 |
| aspiera anti-fungal | OTC monograph final | 2012-07-22 |
Show 145 more
Indications
FDA
EMA
Show 5 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB18: Clotrimazole
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AC: Imidazole and triazole derivatives, topical antifungals
— D01AC01: Clotrimazole
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AF: Imidazole derivatives, gyncological antiinfectives
— G01AF02: Clotrimazole
HCPCS
No data
Clinical
Clinical Trials
179 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vulvovaginal candidiasis | D002181 | EFO_0007543 | B37.3 | — | — | 1 | 1 | 2 | 4 |
| Candidiasis | D002177 | — | B37 | — | — | 1 | 1 | 1 | 3 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dermatitis | D003872 | — | L30.9 | — | — | 1 | — | — | 1 |
| Photoallergic dermatitis | D017454 | — | L56.2 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bacterial vaginosis | D016585 | EFO_0003932 | — | — | — | — | — | 1 | 1 |
| Vaginitis | D014627 | EFO_0005757 | N76 | — | — | — | — | 1 | 1 |
| Vaginal diseases | D014623 | — | — | — | — | — | — | 1 | 1 |
| Trichomonas vaginitis | D014247 | EFO_0007521 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Clotrimazole |
| INN | clotrimazole |
| Description | Clotrimazole is a member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group. It has a role as an antiinfective agent, an environmental contaminant and a xenobiotic. It is a member of imidazoles, a member of monochlorobenzenes, a conazole antifungal drug and an imidazole antifungal drug. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 |
Identifiers
| PDB | — |
| CAS-ID | 23593-75-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL104 |
| ChEBI ID | 3764 |
| PubChem CID | 2812 |
| DrugBank | DB00257 |
| UNII ID | G07GZ97H65 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
NR1I3
NR1I3
Organism
Homo sapiens
Gene name
NR1I3
Gene synonyms
CAR
NCBI Gene ID
Protein name
nuclear receptor subfamily 1 group I member 3
Protein synonyms
CAR, Constitutive activator of retinoid response, constitutive active receptor, Constitutive active response, Constitutive androstane receptor, orphan nuclear hormone receptor, Orphan nuclear receptor MB67
Uniprot ID
Mouse ortholog
Nr1i3 (12355)
nuclear receptor subfamily 1 group I member 3 (O35627)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Clotrimazole
+
Betamethasone
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Clotrimazole
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 7,898 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
5,457 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use