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AboutPricing
Drug ReportsClotrimazole
Clotrimazole
Clotrimazole, Trivagizole (clotrimazole) is a small molecule pharmaceutical. Clotrimazole was first approved as Mycelex on 1982-01-01. It is used to treat cutaneous candidiasis, mycoses, oral candidiasis, tinea pedis, and vulvovaginal candidiasis in the USA. It is known to target transient receptor potential cation channel subfamily M member 8, intermediate conductance calcium-activated potassium channel protein 4, transient receptor potential cation channel subfamily M member 4, nuclear receptor subfamily 1 group I member 2, transient receptor potential cation channel subfamily M member 2, and nuclear receptor subfamily 1 group I member 3.
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3M
6M
YTD
1Y
2Y
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
stomatognathic diseasesD009057
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Clotrimazole, Trivagizole (discontinued: Gyne-lotrimin, Gynix, Lotrimin, Mycelex)
Combinations
Clotrimazole betamethasone (discontinued: Lotrisone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clotrimazole
Tradename
Company
Number
Date
Products
TRIVAGIZOLE 3Taro PharmaceuticalN-021143 OTC2000-04-12
1 products
Show 16 discontinued
Betamethasone dipropionate
+
Clotrimazole
Tradename
Company
Number
Date
Products
LOTRISONEMerck & CoN-020010 DISCN2000-12-08
1 products, RLD
LOTRISONEOrganonN-018827 DISCN1984-07-10
1 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
1med clotrimazole 1% antifungal creamOTC monograph final2022-02-04
akin anti-fungalC2002632023-11-29
alevazolunapproved drug other2024-01-02
anti-fungalC2002632024-05-17
anti-fungal creamOTC monograph final2020-01-08
antifungalC2002632024-11-08
antifungal 1% clotrimazole creamC2002632024-12-16
antifungal creamOTC monograph final2013-11-07
aptrimazoleOTC monograph final2013-04-27
aspiera anti-fungalOTC monograph final2012-07-22
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
mycoses—D009181B35-B49
oral candidiasisEFO_0007406D002180B37.0
vulvovaginal candidiasisEFO_0007543D002181B37.3
tinea pedisEFO_0007512D014008B35.3
cutaneous candidiasis—D002179—
psoriasisEFO_0000676D011565L40
atopic dermatitisEFO_0000274D003876L20
pruritus ani—D011538L29.0
inflammationMP_0001845D007249—
facial dermatoses—D005148—
Show 5 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB18: Clotrimazole
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AC: Imidazole and triazole derivatives, topical antifungals
— D01AC01: Clotrimazole
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AF: Imidazole derivatives, gyncological antiinfectives
— G01AF02: Clotrimazole
HCPCS
No data
Clinical
Clinical Trials
175 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TineaD014005EFO_0007510B35.43————3
Tinea pedisD014008EFO_0007512B35.33————3
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameClotrimazole
INNclotrimazole
Description
Clotrimazole is a member of the class of imidazoles that is 1H-imidazole in which the hydrogen attached to a nitrogen is replaced by a monochlorotrityl group. It has a role as an antiinfective agent, an environmental contaminant and a xenobiotic. It is a member of imidazoles, a member of monochlorobenzenes, a conazole antifungal drug and an imidazole antifungal drug.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1
Identifiers
PDB—
CAS-ID23593-75-1
RxCUI—
ChEMBL IDCHEMBL104
ChEBI ID3764
PubChem CID2812
DrugBankDB00257
UNII IDG07GZ97H65 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
NR1I3
NR1I3
Organism
Homo sapiens
Gene name
NR1I3
Gene synonyms
CAR
NCBI Gene ID
9970
Protein name
nuclear receptor subfamily 1 group I member 3
Protein synonyms
CAR, Constitutive activator of retinoid response, constitutive active receptor, Constitutive active response, Constitutive androstane receptor, orphan nuclear hormone receptor, Orphan nuclear receptor MB67
Uniprot ID
Q14994
Mouse ortholog
Nr1i3 (12355)
nuclear receptor subfamily 1 group I member 3 (O35627)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Clotrimazole
+
Betamethasone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Clotrimazole
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,720 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,300 adverse events reported
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