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Drug ReportsClonidine
Clonidine
Catapres, Clonidine, Clorpres, Combipres, Duraclon, Nexiclon, Onyda (clonidine) is a small molecule pharmaceutical. Clonidine was first approved as Combipres on 1982-01-01. It is used to treat attention deficit disorder with hyperactivity, diarrhea, dysmenorrhea, glaucoma, and hot flashes amongst others in the USA. The pharmaceutical is active against alpha-2B adrenergic receptor and alpha-2A adrenergic receptor. In addition, it is known to target potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, solute carrier family 22 member 1, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, alpha-2C adrenergic receptor, and alpha-1D adrenergic receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
stomatognathic diseasesD009057
nervous system diseasesD009422
eye diseasesD005128
cardiovascular diseasesD002318
hereditary congenital and neonatal diseases and abnormalitiesD009358
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Catapres, Clonidine, Duraclon, Nexiclon, Onyda (discontinued: Catapres, Clonidine, Duraclon, Kapvay, Nexiclon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clonidine hydrochloride
Tradename
Company
Number
Date
Products
DURACLONMylanN-020615 RX1996-10-02
1 products, RLD
ONYDA XRTris PharmaN-217645 RX2024-05-24
1 products, RLD, RS
Show 4 discontinued
Chlorthalidone
+
Clonidine hydrochloride
Tradename
Company
Number
Date
Products
COMBIPRESBoehringer IngelheimN-017503 DISCN1982-01-01
3 products, RLD
Hide discontinued
Clonidine
Tradename
Company
Number
Date
Products
NEXICLON XRAthena NeurosciencesN-022500 RX2009-12-03
1 products
CATAPRES-TTS-1LavipharmN-018891 RX1984-10-10
1 products, RLD
CATAPRES-TTS-2LavipharmN-018891 RX1984-10-10
1 products, RLD
CATAPRES-TTS-3LavipharmN-018891 RX1984-10-10
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
catapresNew Drug Application2010-12-10
catapres-tts-1 catapres-tts-2 catapres-tts-3New Drug Application2024-10-11
clondineANDA2010-03-15
clonidineANDA2024-02-05
clonidine hciANDA2022-12-09
clonidine hydrochlorideANDA2025-03-27
clonidine hydrochloride tabletsANDA2009-09-18
clonidine transdermal systemANDA2023-11-28
clonidine transdermal system usp, 0.1 mg/day clonidine transdermal system usp, 0.2 mg/day clonidine transdermal system usp, 0.3 mg/dayNew Drug Application2024-10-14
duraclonNew Drug Application2021-03-17
Show 2 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hypertensionEFO_0000537D006973I10
substance withdrawal syndromeEFO_0005800D013375—
diarrhea—D003967R19.7
muscle spasticity—D009128—
glaucomaEFO_0000516D005901H40
sialorrhea—D012798K11.7
tourette syndromeEFO_0004895D005879F95.2
dysmenorrhea—D004412N94.6
hot flashes—D019584—
intractable pain—D010148—
Show 7 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Clonidine, Nexiclon Xr, Athena
86234092031-09-08DP
83378902027-04-17DP
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02A: Antiadrenergic agents, centrally acting
— C02AC: Imidazoline receptor agonists
— C02AC01: Clonidine
— C02L: Antihypertensives and diuretics in combination
— C02LC: Imidazoline receptor agonists in combination with diuretics
— C02LC01: Clonidine and diuretics
— C02LC51: Clonidine and diuretics, combinations with other drugs
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CX: Other antimigraine preparations in atc
— N02CX02: Clonidine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EA: Sympathomimetics in glaucoma therapy
— S01EA04: Clonidine
HCPCS
Code
Description
J0735
Injection, clonidine hydrochloride, 1 mg
Clinical
Clinical Trials
328 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperkinesisD006948—————1—1
Attention deficit disorder with hyperactivityD001289EFO_0003888F90———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameClonidine
INNclonidine
Description
Clonidine (imino form) is a clonidine. It is a tautomer of a clonidine (amino form).
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Clc1cccc(Cl)c1NC1=NCCN1
Identifiers
PDB—
CAS-ID4205-90-7
RxCUI—
ChEMBL IDCHEMBL134
ChEBI ID3757
PubChem CID2803
DrugBankDB00575
UNII IDMN3L5RMN02 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
146
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Q9NPY0
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (P97714)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Clonidine
+
Chlorthalidone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Clonidine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 23,899 documents
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Safety
Black-box Warning
Black-box warning for: Duraclon
Adverse Events
Top Adverse Reactions
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18,108 adverse events reported
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