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Drug ReportsClonidine
Clonidine
Catapres, Clonidine, Clorpres, Combipres, Duraclon, Nexiclon, Onyda (clonidine) is a small molecule pharmaceutical. Clonidine was first approved as Combipres on 1982-01-01. It is used to treat attention deficit disorder with hyperactivity, diarrhea, dysmenorrhea, glaucoma, and hot flashes amongst others in the USA. The pharmaceutical is active against alpha-2B adrenergic receptor and alpha-2A adrenergic receptor. In addition, it is known to target potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, solute carrier family 22 member 1, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, alpha-2C adrenergic receptor, and alpha-1D adrenergic receptor.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
stomatognathic diseasesD009057
nervous system diseasesD009422
eye diseasesD005128
cardiovascular diseasesD002318
hereditary congenital and neonatal diseases and abnormalitiesD009358
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Catapres, Clonidine, Duraclon, Nexiclon, Onyda (discontinued: Catapres, Clonidine, Duraclon, Kapvay, Nexiclon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clonidine hydrochloride
Tradename
Company
Number
Date
Products
DURACLONMylanN-020615 RX1996-10-02
1 products, RLD
ONYDA XRTris PharmaN-217645 RX2024-05-24
1 products, RLD, RS
Show 4 discontinued
Chlorthalidone
+
Clonidine hydrochloride
Tradename
Company
Number
Date
Products
COMBIPRESBoehringer IngelheimN-017503 DISCN1982-01-01
3 products, RLD
Hide discontinued
Clonidine
Tradename
Company
Number
Date
Products
NEXICLON XRAthena NeurosciencesN-022500 RX2009-12-03
1 products
CATAPRES-TTS-1LavipharmN-018891 RX1984-10-10
1 products, RLD
CATAPRES-TTS-2LavipharmN-018891 RX1984-10-10
1 products, RLD
CATAPRES-TTS-3LavipharmN-018891 RX1984-10-10
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
catapresNew Drug Application2010-12-10
catapres-tts-1 catapres-tts-2 catapres-tts-3New Drug Application2024-10-11
clondineANDA2010-03-15
clonidineANDA2024-02-05
clonidine hciANDA2022-12-09
clonidine hydrochlorideANDA2024-10-23
clonidine hydrochloride tabletsANDA2009-09-18
clonidine transdermal systemANDA2023-11-28
clonidine transdermal system usp, 0.1 mg/day clonidine transdermal system usp, 0.2 mg/day clonidine transdermal system usp, 0.3 mg/dayNew Drug Application2024-10-14
duraclonNew Drug Application2021-03-17
Show 2 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Clonidine, Nexiclon Xr, Athena
86234092031-09-08DP
83378902027-04-17DP
ATC Codes
C: Cardiovascular system drugs
— C02: Antihypertensives
— C02A: Antiadrenergic agents, centrally acting
— C02AC: Imidazoline receptor agonists
— C02AC01: Clonidine
— C02L: Antihypertensives and diuretics in combination
— C02LC: Imidazoline receptor agonists in combination with diuretics
— C02LC01: Clonidine and diuretics
— C02LC51: Clonidine and diuretics, combinations with other drugs
N: Nervous system drugs
— N02: Analgesics
— N02C: Antimigraine preparations
— N02CX: Other antimigraine preparations in atc
— N02CX02: Clonidine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EA: Sympathomimetics in glaucoma therapy
— S01EA04: Clonidine
HCPCS
Code
Description
J0735
Injection, clonidine hydrochloride, 1 mg
Clinical
Clinical Trials
324 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postoperative painD010149—G89.1865315834
PainD010146EFO_0003843R521942520
HypertensionD006973EFO_0000537I104317418
Substance withdrawal syndromeD013375EFO_0005800—3542215
Opioid-related disordersD009293EFO_0005611F114531212
Neonatal abstinence syndromeD009357EFO_0005799P96.12423211
SyndromeD013577———3—519
Replacement arthroplasty kneeD019645——1——438
AnesthesiaD000758———21328
DeliriumD003693—R41.0—12418
Show 117 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetic neuropathiesD003929EFO_1000783——41——5
Substance-related disordersD019966EFO_0003890F13231——4
Laron syndromeD046150Orphanet_633E34.321——2—24
Heroin dependenceD006556EFO_0004240—1—2——3
StrokeD020521EFO_0000712I63.9——1—23
Diabetes mellitusD003920HP_0000819E08-E13111——3
Morphine dependenceD009021EFO_0005612———2——2
TendinopathyD052256EFO_1001434M77.9——1—12
Migraine disordersD008881EFO_0003821G43——1—12
Postoperative nausea and vomitingD020250EFO_0004888———1—12
Show 31 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———51——17
HemorrhageD006470MP_0001914R5811——35
Breast neoplasmsD001943EFO_0003869C5012———3
Parkinson diseaseD010300EFO_0002508G20—2——13
NeuralgiaD009437EFO_0009430——3———3
Brain injuriesD001930—S06.911——13
Peripheral nervous system diseasesD010523HP_0009830G64—3———3
HerniaD006547HP_0100790K40-K46—1——12
Subarachnoid hemorrhageD013345EFO_0000713I60—1——12
TachycardiaD013610HP_0001649R00.011——12
Show 51 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Blood pressureD001794EFO_0004325—2————2
Pure autonomic failureD054970——1————1
RecurrenceD012008——1————1
Male circumcisionD002944EFO_0003953—1————1
Vascular stiffnessD059289——1————1
Isolated systolic hypertensionD000092244——1————1
Autonomic nervous system diseasesD001342EFO_0009532G901————1
HypotensionD007022EFO_0005251I951————1
Orthostatic hypotensionD007024—I95.11————1
Nervous system diseasesD009422—G00-G991————1
Show 14 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382——————22
Cerebral hemorrhageD002543——————22
Sleep initiation and maintenance disordersD007319—F51.01————22
Mental disordersD001523EFO_0000677F91.9————11
Ganglion cystsD045888—M67.4————11
ProstatectomyD011468——————11
Tennis elbowD013716EFO_1001896M77.1————11
PregnancyD011247EFO_0002950Z33.1————11
Pilonidal sinusD010864HP_0010769L05————11
Ventral herniaD006555EFO_1001866K43————11
Show 40 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameClonidine
INNclonidine
Description
Clonidine (imino form) is a clonidine. It is a tautomer of a clonidine (amino form).
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Clc1cccc(Cl)c1NC1=NCCN1
Identifiers
PDB—
CAS-ID4205-90-7
RxCUI—
ChEMBL IDCHEMBL134
ChEBI ID3757
PubChem CID2803
DrugBankDB00575
UNII IDMN3L5RMN02 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
ADRA1D
Gene synonyms
ADRA1A
NCBI Gene ID
Protein name
alpha-1D adrenergic receptor
Protein synonyms
adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, Alpha-1A adrenergic receptor, Alpha-1D adrenoceptor, Alpha-1D adrenoreceptor, Alpha-adrenergic receptor 1a
Uniprot ID
Mouse ortholog
Adra1d (11550)
alpha-1D adrenergic receptor (P97714)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Clonidine
+
Chlorthalidone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Clonidine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 22,996 documents
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Safety
Black-box Warning
Black-box warning for: Duraclon
Adverse Events
Top Adverse Reactions
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17,066 adverse events reported
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