PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsClonazepam
Clonazepam
Clonazepam, Klonopin (clonazepam) is a small molecule pharmaceutical. Clonazepam was first approved as Klonopin on 1982-01-01. It is used to treat absence epilepsy, bipolar disorder, dysarthria, lennox gastaut syndrome, and myoclonic epilepsies amongst others in the USA. The pharmaceutical is active against gamma-aminobutyric acid receptor subunit alpha-1, gamma-aminobutyric acid receptor subunit alpha-3, and gamma-aminobutyric acid receptor subunit alpha-2.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
Clonazepam, Klonopin (discontinued: Clonazepam, Klonopin, Klonopin rapidly disintegrating)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clonazepam
Tradename
Company
Number
Date
Products
KLONOPINCHEPLAPHARM ArzneimittelN-017533 RX1982-01-01
3 products, RLD
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
clonazepamANDA2025-02-12
klonopinNew Drug Application2024-12-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
tic disorders—D013981F95
neuralgiaEFO_0009430D009437—
restless legs syndromeEFO_0004270D012148G25.81
myoclonic epilepsiesEFO_1001900D004831G40.4
lennox gastaut syndrome—D065768G40.81
seizures—D012640G40.4
absence epilepsy—D004832G40.A
dysarthria—D004401—
schizophreniaEFO_0000692D012559F20
bipolar disorderEFO_0000289D001714F30.9
Show 1 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N03: Antiepileptics
— N03A: Antiepileptics
— N03AE: Benzodiazepine derivative antiepileptics
— N03AE01: Clonazepam
HCPCS
No data
Clinical
Clinical Trials
52 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharmacokineticsD010599——1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameClonazepam
INNclonazepam
Description
Clonazepam is 1,3-Dihydro-2H-1,4-benzodiazepin-2-one in which the hydrogens at positions 5 and 7 are substituted by 2-chlorophenyl and nitro groups, respectively. It is used in the treatment of all types of epilepsy and seizures, as well as myoclonus and associated abnormal movements, and panic disorders. However, its use can be limited by the development of tolerance and by sedation. It has a role as an anticonvulsant, a GABA modulator and an anxiolytic drug. It is a 1,4-benzodiazepinone and a member of monochlorobenzenes.
Classification
Small molecule
Drug classantianxiety agents (diazepam type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C1CN=C(c2ccccc2Cl)c2cc([N+](=O)[O-])ccc2N1
Identifiers
PDB—
CAS-ID1622-61-3
RxCUI—
ChEMBL IDCHEMBL452
ChEBI ID3756
PubChem CID2802
DrugBankDB01068
UNII ID5PE9FDE8GB (ChemIDplus, GSRS)
Target
Agency Approved
GABRA1
GABRA1
GABRA3
GABRA3
GABRA2
GABRA2
Organism
Homo sapiens
Gene name
GABRA1
Gene synonyms
NCBI Gene ID
2554
Protein name
gamma-aminobutyric acid receptor subunit alpha-1
Protein synonyms
GABA(A) receptor subunit alpha-1, GABA(A) receptor, alpha 1, gamma-aminobutyric acid (GABA) A receptor, alpha 1, gamma-aminobutyric acid type A receptor alpha1 subunit
Uniprot ID
Q8N629
Mouse ortholog
Gabra1 (14394)
gamma-aminobutyric acid receptor subunit alpha-1 (P62812)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Clonazepam
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 14,634 documents
View more details
Safety
Black-box Warning
Black-box warning for: Clonazepam, Klonopin
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
50,794 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use