Brand Name | Status | Last Update |
---|---|---|
anafranil | New Drug Application | 2024-11-26 |
clomipramine hcl | ANDA | 2024-12-09 |
clomipramine hydrochloride | ANDA | 2024-12-23 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Depression | D003863 | — | F33.9 | 2 | — | — | — | — | 2 |
Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
Drug common name | Clomipramine |
INN | clomipramine |
Description | Clomipramine is a dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias. It has a role as a serotonergic antagonist, a serotonergic drug, a serotonin uptake inhibitor, an EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor, an antidepressant and an anticoronaviral agent. It is functionally related to an imipramine. It is a conjugate base of a clomipramine(1+). |
Classification | Small molecule |
Drug class | antidepressants (imipramine type) |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21 |
PDB | — |
CAS-ID | 303-49-1 |
RxCUI | — |
ChEMBL ID | CHEMBL415 |
ChEBI ID | 47780 |
PubChem CID | 2801 |
DrugBank | DB01242 |
UNII ID | NUV44L116D (ChemIDplus, GSRS) |