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AboutPricing
Drug ReportsClomipramine
Clomipramine
Anafranil, Clomipramine (clomipramine) is a small molecule pharmaceutical. Clomipramine was first approved as Anafranil on 1989-12-29. It is used to treat depressive disorder, obsessive-compulsive disorder, pain, panic disorder, and psychotic affective disorders in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter. In addition, it is known to target sodium-dependent dopamine transporter, G protein-activated inward rectifier potassium channel 4, and G protein-activated inward rectifier potassium channel 2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
psychological phenomenaD011579
mental disordersD001523
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Anafranil, Clomipramine (discontinued: Clomipramine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clomipramine hydrochloride
Tradename
Company
Number
Date
Products
ANAFRANILSPECGXN-019906 RX1989-12-29
3 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
anafranilNew Drug Application2024-11-26
clomipramine hclANDA2024-12-09
clomipramine hydrochlorideANDA2025-06-11
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
painEFO_0003843D010146R52
panic disorderEFO_0004262D016584F41.0
psychotic affective disorders—D000341F39
obsessive-compulsive disorderEFO_0004242D009771F42
depressive disorderEFO_1002014D003866F32.A
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AA: Non-selective monoamine reuptake inhibitors
— N06AA04: Clomipramine
HCPCS
No data
Clinical
Clinical Trials
32 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863—F33.92————2
MalnutritionD044342EFO_0008572E40-E461————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameClomipramine
INNclomipramine
Description
Clomipramine is a dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias. It has a role as a serotonergic antagonist, a serotonergic drug, a serotonin uptake inhibitor, an EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor, an antidepressant and an anticoronaviral agent. It is functionally related to an imipramine. It is a conjugate base of a clomipramine(1+).
Classification
Small molecule
Drug classantidepressants (imipramine type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
Identifiers
PDB—
CAS-ID303-49-1
RxCUI—
ChEMBL IDCHEMBL415
ChEBI ID47780
PubChem CID2801
DrugBankDB01242
UNII IDNUV44L116D (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Clomipramine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,405 documents
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Safety
Black-box Warning
Black-box warning for: Anafranil, Clomipramine hcl, Clomipramine hydrochloride
Adverse Events
Top Adverse Reactions
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5,797 adverse events reported
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