Clomiphene
Clomiphene (clomiphene) is a small molecule pharmaceutical. Clomiphene was first approved as Clomid on 1982-01-01. It is used to treat female infertility and male infertility in the USA. The pharmaceutical is active against estrogen receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Clomiphene (discontinued: Clomid, Serophene)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clomiphene citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SEROPHENE | EMD Serono | N-018361 DISCN | 1982-03-22 | 1 products |
| CLOMID | Sanofi | N-016131 DISCN | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clomid | ANDA | 2025-01-31 |
| clomiphene citrate | ANDA | 2026-07-16 |
| milophene | ANDA | 2025-10-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| male infertility | EFO_0004248 | D007248 | N46 |
| female infertility | EFO_0008560 | D007247 | N97 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9940 | Documentation of medical reason(s) for not on a statin (e.g., pregnancy, in vitro fertilization, clomiphene rx, esrd, cirrhosis, muscular pain and disease during the measurement period or prior year) |
Clinical
Clinical Trials
259 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | EFO_0000545 | — | 9 | 15 | 21 | 40 | 35 | 111 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 7 | 13 | 23 | 25 | 34 | 96 |
| Syndrome | D013577 | — | — | — | 4 | 7 | 13 | 23 | 46 |
| Anovulation | D000858 | — | — | 1 | 5 | 5 | 6 | 7 | 24 |
| Female infertility | D007247 | EFO_0008560 | N97 | 2 | 2 | 4 | 7 | 9 | 22 |
| Ovulation induction | D010062 | — | — | — | — | 3 | 4 | 3 | 10 |
| Male infertility | D007248 | EFO_0004248 | N46 | 1 | 3 | 2 | 2 | 1 | 7 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 3 | 2 | 1 | 7 |
| Endometriosis | D004715 | EFO_0001065 | N80 | — | — | — | 1 | 3 | 4 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | 3 | — | 1 | — | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypogonadism | D007006 | — | E23.0 | 3 | 13 | 9 | — | 2 | 27 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 4 | 6 | — | — | 10 |
| Azoospermia | D053713 | EFO_0000279 | N46.0 | 1 | 1 | 1 | — | 1 | 3 |
| Hyperandrogenism | D017588 | — | — | — | 2 | 1 | — | — | 3 |
| Leiomyoma | D007889 | — | D25 | 1 | — | 1 | — | — | 2 |
| Overweight | D050177 | — | E66.3 | — | — | 2 | — | — | 2 |
| Spontaneous abortion | D000022 | EFO_1001255 | O00.1 | — | — | 1 | — | — | 1 |
| Gestational diabetes | D016640 | — | O24.4 | — | — | 1 | — | — | 1 |
| Toxemia | D014115 | — | — | — | — | 1 | — | — | 1 |
| Ovulation | D010060 | — | — | — | — | 1 | — | — | 1 |
Show 1 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Eunuchism | D005058 | EFO_0007266 | E29.1 | — | 2 | — | — | 1 | 3 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | 1 | 1 | — | — | 1 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 2 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | — | — | — | 2 |
| Gonadal disorders | D006058 | — | — | 1 | 1 | — | — | — | 1 |
| Uterine hemorrhage | D014592 | — | — | — | 1 | — | — | — | 1 |
| Hyperprolactinemia | D006966 | — | E22.1 | — | 1 | — | — | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | — | 1 |
| Acromegaly | D000172 | — | — | — | 1 | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
Show 7 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy rate | D018873 | — | — | 1 | — | — | — | 2 | 3 |
| Ovarian hyperstimulation syndrome | D016471 | — | — | 1 | — | — | — | 1 | 2 |
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperthermia | D000084462 | — | — | — | — | — | — | 4 | 4 |
| Hyperinsulinism | D006946 | — | E16.1 | — | — | — | — | 2 | 2 |
| Thrombosis | D013927 | — | — | — | — | — | — | 1 | 1 |
| Rare diseases | D035583 | — | — | — | — | — | — | 1 | 1 |
| Ectopic pregnancy | D011271 | — | O00 | — | — | — | — | 1 | 1 |
| Hysteroscopy | D015907 | — | — | — | — | — | — | 1 | 1 |
| Asymptomatic diseases | D058070 | — | — | — | — | — | — | 1 | 1 |
| Affect | D000339 | — | — | — | — | — | — | 1 | 1 |
| Colorectal neoplasms | D015179 | — | — | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
Show 9 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clomiphene |
| INN | clomifene |
| Description | Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome. Use results in a greater chance of twins. It is taken by mouth once a day, with a course of treatment that usually lasts for five days.
|
| Classification | Small molecule |
| Drug class | Selective estrogen receptor modulator; Progonadotropin |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 911-45-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2355051 |
| ChEBI ID | 3752 |
| PubChem CID | 2800 |
| DrugBank | DB00882 |
| UNII ID | 1HRS458QU2 (ChemIDplus, GSRS) |
Target
Agency Approved
ESR1
ESR1
Organism
Homo sapiens
Gene name
ESR1
Gene synonyms
ESR, NR3A1
NCBI Gene ID
Protein name
estrogen receptor
Protein synonyms
E2 receptor alpha, ER-alpha, Estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, Nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Uniprot ID
Mouse ortholog
Esr1 (13982)
estrogen receptor (Q9QY52)
Alternate
No data
Variants
No data
Financial
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Estimated US medical usage
Clomiphene
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,667 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,069 adverse events reported
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