Clomiphene
Clomiphene (clomiphene) is a small molecule pharmaceutical. Clomiphene was first approved as Clomid on 1982-01-01. It is used to treat female infertility and male infertility in the USA. The pharmaceutical is active against estrogen receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Clomiphene (discontinued: Clomid, Serophene)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clomiphene citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SEROPHENE | EMD Serono | N-018361 DISCN | 1982-03-22 | 1 products |
| CLOMID | Sanofi | N-016131 DISCN | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clomid | ANDA | 2025-01-31 |
| clomiphene citrate | ANDA | 2025-09-18 |
| milophene | ANDA | 2024-12-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| male infertility | EFO_0004248 | D007248 | N46 |
| female infertility | EFO_0008560 | D007247 | N97 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9940 | Documentation of medical reason(s) for not on a statin (e.g., pregnancy, in vitro fertilization, clomiphene rx, esrd, cirrhosis, muscular pain and disease during the measurement period or prior year) |
Clinical
Clinical Trials
251 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anovulation | D000858 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clomiphene |
| INN | clomifene |
| Description | Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome. Use results in a greater chance of twins. It is taken by mouth once a day, with a course of treatment that usually lasts for five days.
|
| Classification | Small molecule |
| Drug class | Selective estrogen receptor modulator; Progonadotropin |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 911-45-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2355051 |
| ChEBI ID | 3752 |
| PubChem CID | 2800 |
| DrugBank | DB00882 |
| UNII ID | 1HRS458QU2 (ChemIDplus, GSRS) |
Target
Agency Approved
ESR1
ESR1
Organism
Homo sapiens
Gene name
ESR1
Gene synonyms
ESR, NR3A1
NCBI Gene ID
Protein name
estrogen receptor
Protein synonyms
E2 receptor alpha, ER-alpha, Estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, Nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Uniprot ID
Mouse ortholog
Esr1 (13982)
estrogen receptor (Q9QY52)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Clomiphene
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,636 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,039 adverse events reported
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