Clomiphene
Clomiphene (clomiphene) is a small molecule pharmaceutical. Clomiphene was first approved as Clomid on 1982-01-01. It is used to treat female infertility and male infertility in the USA. The pharmaceutical is active against estrogen receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Clomiphene (discontinued: Clomid, Serophene)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clomiphene citrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| SEROPHENE | EMD Serono | N-018361 DISCN | 1982-03-22 | 1 products |
| CLOMID | Sanofi | N-016131 DISCN | 1982-01-01 | 1 products, RLD |
Hide discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clomid | ANDA | 2025-01-31 |
| clomiphene citrate | ANDA | 2025-11-24 |
| milophene | ANDA | 2025-10-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| male infertility | EFO_0004248 | D007248 | N46 |
| female infertility | EFO_0008560 | D007247 | N97 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9940 | Documentation of medical reason(s) for not on a statin (e.g., pregnancy, in vitro fertilization, clomiphene rx, esrd, cirrhosis, muscular pain and disease during the measurement period or prior year) |
Clinical
Clinical Trials
251 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infertility | D007246 | EFO_0000545 | — | 9 | 15 | 21 | 39 | 35 | 110 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 7 | 13 | 22 | 24 | 33 | 93 |
| Syndrome | D013577 | — | — | 1 | 4 | 8 | 13 | 23 | 48 |
| Anovulation | D000858 | — | — | 1 | 5 | 4 | 6 | 7 | 23 |
| Female infertility | D007247 | EFO_0008560 | N97 | 2 | 2 | 4 | 7 | 8 | 21 |
| Ovulation induction | D010062 | — | — | — | — | 3 | 4 | 3 | 10 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | — | 3 | 2 | 1 | 7 |
| Male infertility | D007248 | EFO_0004248 | N46 | 1 | 3 | 2 | 1 | 1 | 6 |
| Endometriosis | D004715 | EFO_0001065 | N80 | — | — | — | 1 | 3 | 4 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | 3 | — | 1 | — | 4 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypogonadism | D007006 | — | E23.0 | 3 | 13 | 9 | — | 2 | 27 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 4 | 6 | — | — | 10 |
| Azoospermia | D053713 | EFO_0000279 | N46.0 | 1 | 1 | 1 | — | 1 | 3 |
| Hyperandrogenism | D017588 | — | — | — | 2 | 1 | — | — | 3 |
| Leiomyoma | D007889 | — | D25 | 1 | — | 1 | — | — | 2 |
| Overweight | D050177 | — | E66.3 | — | — | 2 | — | — | 2 |
| Spontaneous abortion | D000022 | EFO_1001255 | O00.1 | — | — | 1 | — | — | 1 |
| Gestational diabetes | D016640 | — | O24.4 | — | — | 1 | — | — | 1 |
| Toxemia | D014115 | — | — | — | — | 1 | — | — | 1 |
| Ovulation | D010060 | — | — | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Eunuchism | D005058 | EFO_0007266 | E29.1 | — | 2 | — | — | 1 | 3 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | 1 | 1 | — | — | 1 | 2 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 2 | — | — | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | — | — | — | 2 |
| Gonadal disorders | D006058 | — | — | 1 | 1 | — | — | — | 1 |
| Uterine hemorrhage | D014592 | — | — | — | 1 | — | — | — | 1 |
| Hyperprolactinemia | D006966 | — | E22.1 | — | 1 | — | — | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | — | — | — | 1 |
| Acromegaly | D000172 | — | — | — | 1 | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
Show 7 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pregnancy rate | D018873 | — | — | 1 | — | — | — | 2 | 3 |
| Ovarian hyperstimulation syndrome | D016471 | — | — | 1 | — | — | — | 1 | 2 |
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperthermia | D000084462 | — | — | — | — | — | — | 4 | 4 |
| Hyperinsulinism | D006946 | — | E16.1 | — | — | — | — | 2 | 2 |
| Thrombosis | D013927 | — | — | — | — | — | — | 1 | 1 |
| Rare diseases | D035583 | — | — | — | — | — | — | 1 | 1 |
| Ectopic pregnancy | D011271 | — | O00 | — | — | — | — | 1 | 1 |
| Hysteroscopy | D015907 | — | — | — | — | — | — | 1 | 1 |
| Asymptomatic diseases | D058070 | — | — | — | — | — | — | 1 | 1 |
| Affect | D000339 | — | — | — | — | — | — | 1 | 1 |
| Colorectal neoplasms | D015179 | — | — | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
Show 8 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Clomiphene |
| INN | clomifene |
| Description | Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate, including those with polycystic ovary syndrome. Use results in a greater chance of twins. It is taken by mouth once a day, with a course of treatment that usually lasts for five days.
|
| Classification | Small molecule |
| Drug class | Selective estrogen receptor modulator; Progonadotropin |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 911-45-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2355051 |
| ChEBI ID | 3752 |
| PubChem CID | 2800 |
| DrugBank | DB00882 |
| UNII ID | 1HRS458QU2 (ChemIDplus, GSRS) |
Target
Agency Approved
ESR1
ESR1
Organism
Homo sapiens
Gene name
ESR1
Gene synonyms
ESR, NR3A1
NCBI Gene ID
Protein name
estrogen receptor
Protein synonyms
E2 receptor alpha, ER-alpha, Estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, Nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Uniprot ID
Mouse ortholog
Esr1 (13982)
estrogen receptor (Q9QY52)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Clomiphene
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 7,730 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
1,039 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use