Clofibrate
Atromid-s (clofibrate) is a small molecule pharmaceutical. Clofibrate was first approved as Atromid-s on 1982-01-01. It is used to treat coronary artery disease, hypercholesterolemia, hyperlipoproteinemias, and hypertriglyceridemia in the USA. The pharmaceutical is active against peroxisome proliferator-activated receptor alpha.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| nutritional and metabolic diseases | D009750 |
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Indications
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Clinical
Clinical Trials
518 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertriglyceridemia | D015228 | EFO_0004211 | — | 3 | 3 | 14 | 8 | 5 | 32 |
| Healthy volunteers/patients | — | — | — | 14 | — | — | 1 | 12 | 27 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 4 | 4 | 6 | 14 |
| Pain | D010146 | EFO_0003843 | R52 | 2 | — | — | 5 | 6 | 13 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 2 | 3 | 3 | 4 | 11 |
| Infections | D007239 | EFO_0000544 | — | 1 | 2 | 1 | 2 | 6 | 11 |
| Covid-19 | D000086382 | — | — | — | 1 | 3 | 4 | 1 | 9 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 2 | 3 | 4 | 9 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 1 | 2 | 3 | 2 | 9 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | 2 | 4 | 3 | 9 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Recurrence | D012008 | — | — | 17 | 18 | 4 | — | 3 | 38 |
| Carcinoma | D002277 | — | C80.0 | 10 | 18 | 7 | — | 2 | 34 |
| Neoplasms | D009369 | — | C80 | 14 | 13 | 2 | — | — | 26 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 6 | 16 | 6 | — | 1 | 26 |
| Non-small-cell lung carcinoma | D002289 | — | — | 4 | 11 | 6 | — | 1 | 21 |
| Syndrome | D013577 | — | — | 6 | 10 | 2 | — | 1 | 16 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 1 | 10 | 2 | — | 1 | 14 |
| Adenocarcinoma | D000230 | — | — | 4 | 6 | 2 | — | 1 | 12 |
| Carcinoid tumor | D002276 | — | D3A.00 | 2 | 5 | 1 | — | 1 | 9 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 2 | 2 | 5 | — | 1 | 9 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 17 | 9 | — | — | — | 20 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 8 | 8 | — | — | 1 | 14 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 6 | 5 | — | — | 1 | 10 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 6 | 4 | — | — | 1 | 10 |
| Leukemia | D007938 | — | C95 | 8 | 5 | — | — | — | 9 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 9 | 3 | — | — | — | 9 |
| Follicular lymphoma | D008224 | — | C82 | 8 | 4 | — | — | — | 9 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 6 | 3 | — | — | — | 7 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 7 | 2 | — | — | — | 7 |
| B-cell lymphoma | D016393 | — | — | 7 | 2 | — | — | — | 7 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulpitis | D011671 | EFO_1001139 | K04.0 | 1 | — | — | — | 2 | 3 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | — | — | — | — | 2 |
| Hematologic neoplasms | D019337 | — | — | 2 | — | — | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | 2 | — | — | — | — | 2 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 2 | — | — | — | — | 2 |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | — | — | — | 1 | 2 |
| Medullary carcinoma | D018276 | — | — | 2 | — | — | — | — | 2 |
| Hepatic insufficiency | D048550 | — | — | 2 | — | — | — | — | 2 |
| Tongue neoplasms | D014062 | EFO_0003871 | C02.9 | 2 | — | — | — | — | 2 |
| Laryngeal neoplasms | D007822 | EFO_0003817 | C32 | 2 | — | — | — | — | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 4 | 4 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 4 | 4 |
| Back pain | D001416 | HP_0003418 | M54 | — | — | — | — | 3 | 3 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | — | — | — | — | 3 | 3 |
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 3 | 3 |
| Flatfoot | D005413 | EFO_0003874 | — | — | — | — | — | 3 | 3 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | — | — | — | — | 2 | 2 |
| Cachexia | D002100 | HP_0004326 | R64 | — | — | — | — | 2 | 2 |
| Cardiac surgical procedures | D006348 | — | — | — | — | — | — | 2 | 2 |
| Keratoconjunctivitis sicca | D007638 | EFO_1000906 | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clofibrate |
| INN | calcium clofibrate |
| Description | Clofibrate is the ethyl ester of clofibric acid. It has a role as an anticholesteremic drug, an antilipemic drug, a geroprotector and a PPARalpha agonist. It is an aromatic ether, a member of monochlorobenzenes and an ethyl ester. It is functionally related to a clofibric acid. |
| Classification | Small molecule |
| Drug class | antihyperlipidemics (clofibrate type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 637-07-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL565 |
| ChEBI ID | 3750 |
| PubChem CID | 2796 |
| DrugBank | DB00636 |
| UNII ID | TT85QFR500 (ChemIDplus, GSRS) |
Target
Agency Approved
PPARA
PPARA
Organism
Homo sapiens
Gene name
PPARA
Gene synonyms
NR1C1, PPAR
NCBI Gene ID
Protein name
peroxisome proliferator-activated receptor alpha
Protein synonyms
Nuclear receptor subfamily 1 group C member 1, peroxisome proliferative activated receptor, alpha
Uniprot ID
Mouse ortholog
Ppara (19013)
peroxisome proliferator-activated receptor alpha (P23204)
Alternate
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Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Clofibrate
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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61 adverse events reported
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