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Drug ReportsClofibrate
Clofibrate
Atromid-s (clofibrate) is a small molecule pharmaceutical. Clofibrate was first approved as Atromid-s on 1982-01-01. It is used to treat coronary artery disease, hypercholesterolemia, hyperlipoproteinemias, and hypertriglyceridemia in the USA. The pharmaceutical is active against peroxisome proliferator-activated receptor alpha.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clofibrate
Tradename
Company
Number
Date
Products
ATROMID-SWyethN-016099 DISCN1982-01-01
1 products
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Labels
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C10: Lipid modifying agents
C10A: Lipid modifying agents, plain
C10AB: Fibrates, lipid modifying drugs, plain
C10AB01: Clofibrate
C10AB03: Aluminium clofibrate
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertriglyceridemiaD015228EFO_000421133137530
Healthy volunteers/patients1311125
Cardiovascular diseasesD002318EFO_0000319I9823712
PainD010146EFO_0003843R5224612
Covid-19D000086382U07.113419
Diabetes mellitusD003920EFO_0000400E08-E1322339
Type 2 diabetes mellitusD003924EFO_0001360E11112318
Myocardial infarctionD009203EFO_0000612I213238
Myocardial ischemiaD017202EFO_1001375I20-I252338
Coronary artery diseaseD003324I25.12428
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
CarcinomaD002277C80.07167231
RecurrenceD01200813133430
NeoplasmsD009369C801313124
Lung neoplasmsD008175C34.903136120
Non-small-cell lung carcinomaD002289386117
SyndromeD013577692115
Neuroendocrine tumorsD018358EFO_1001901D3A.8110213
AdenocarcinomaD000230462112
Alzheimer diseaseD000544EFO_0000249F0322519
Carcinoid tumorD002276D3A.0015118
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Indications Phases 2
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alcohol drinkingD000428EFO_0004329224
PulpitisD011671EFO_1001139K04.0123
Myeloid leukemia acuteD015470C92.022
Hematologic neoplasmsD01933722
Myeloid leukemiaD007951C9222
Hepatic insufficiencyD04855022
Tongue neoplasmsD014062EFO_0003871C02.922
Laryngeal neoplasmsD007822EFO_0003817C3222
Verrucous carcinomaD01828922
Laryngeal diseasesD007818J38.722
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Back painD001416M5433
Uterine cervical neoplasmsD00258333
Dental cariesD003731EFO_0003819K0233
FlatfootD005413EFO_0003874M21.433
Keratoconjunctivitis siccaD007638EFO_100090622
Dry eye syndromesD015352H04.1222
Low back painD017116M54.522
AlcoholismD000437EFO_0003829F10.122
AnesthesiaD00075822
Rheumatoid arthritisD001172EFO_0000685M06.922
Show 104 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameClofibrate
INNcalcium clofibrate
Description
Clofibrate is the ethyl ester of clofibric acid. It has a role as an anticholesteremic drug, an antilipemic drug, a geroprotector and a PPARalpha agonist. It is an aromatic ether, a member of monochlorobenzenes and an ethyl ester. It is functionally related to a clofibric acid.
Classification
Small molecule
Drug classantihyperlipidemics (clofibrate type)
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Structure (InChI/SMILES or Protein Sequence)
CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
Identifiers
PDB
CAS-ID637-07-0
RxCUI
ChEMBL IDCHEMBL565
ChEBI ID3750
PubChem CID2796
DrugBankDB00636
UNII IDTT85QFR500 (ChemIDplus, GSRS)
Target
Agency Approved
PPARA
PPARA
Organism
Homo sapiens
Gene name
PPARA
Gene synonyms
NR1C1, PPAR
NCBI Gene ID
Protein name
peroxisome proliferator-activated receptor alpha
Protein synonyms
Nuclear receptor subfamily 1 group C member 1, peroxisome proliferative activated receptor, alpha
Uniprot ID
Mouse ortholog
Ppara (19013)
peroxisome proliferator-activated receptor alpha (P23204)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
£
No data
Estimated US medical usage
Clofibrate
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 236,880 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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114 adverse events reported
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