Clolar, Evoltra(clofarabine)
Clolar, Evoltra (clofarabine) is a small molecule pharmaceutical. Clofarabine was first approved as Clolar on 2004-12-28. It is used to treat lymphoid leukemia in the USA. It has been approved in Europe to treat precursor cell lymphoblastic leukemia-lymphoma. The pharmaceutical is active against ribonucleoside-diphosphate reductase subunit M2. In addition, it is known to target ribonucleoside-diphosphate reductase large subunit.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Clolar (generic drugs available since 2017-05-09)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clofarabine | NDA authorized generic | 2023-12-07 |
| clolar | New Drug Application | 2023-11-15 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| lymphoid leukemia | — | D007945 | C91 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9027 | Injection, clofarabine, 1 mg |
Clinical
Clinical Trials
178 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 22 | 48 | 5 | — | 2 | 67 |
| Myelodysplastic syndromes | D009190 | — | D46 | 21 | 32 | 2 | — | — | 46 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 16 | 28 | 3 | — | 1 | 42 |
| Leukemia | D007938 | — | C95 | 24 | 28 | 3 | — | 1 | 42 |
| Myeloid leukemia | D007951 | — | C92 | 1 | 1 | 1 | — | — | 3 |
| Bone marrow transplantation | D016026 | — | — | 1 | — | 1 | — | — | 2 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | 1 | — | 1 | — | — | 2 |
| Monocytic leukemia acute | D007948 | — | — | 1 | — | 1 | — | — | 2 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | 1 | — | 1 | — | — | 2 |
| Erythroblastic leukemia acute | D004915 | EFO_1001257 | C94.0 | 1 | — | 1 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 7 | 12 | — | — | — | 15 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 3 | 9 | — | — | — | 11 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 4 | 7 | — | — | — | 10 |
| Hodgkin disease | D006689 | — | C81 | 6 | 8 | — | — | — | 10 |
| Neoplasms | D009369 | — | C80 | 7 | 3 | — | — | 1 | 9 |
| Lymphoma | D008223 | — | C85.9 | 7 | 7 | — | — | — | 9 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 5 | 5 | — | — | — | 8 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 6 | — | — | — | 7 |
| Hematologic neoplasms | D019337 | — | — | 4 | 1 | — | — | 1 | 5 |
| Burkitt lymphoma | D002051 | — | C83.7 | 2 | 4 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloproliferative disorders | D009196 | — | D47.1 | 2 | — | — | — | — | 2 |
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 1 | — | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
| Neutropenia | D009503 | — | D70 | 1 | — | — | — | — | 1 |
| Bone marrow diseases | D001855 | — | — | 1 | — | — | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | — | — | — | 1 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | — | — | — | — | 1 |
| Autoimmune diseases | D001327 | HP_0002960 | M30-M36 | 1 | — | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | 1 | — | — | — | — | 1 |
| Takayasu arteritis | D013625 | EFO_1001857 | M31.4 | 1 | — | — | — | — | 1 |
Show 4 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Peroxisomal disorders | D018901 | Orphanet_44 | E71.5 | — | — | — | — | 1 | 1 |
| Lysosomal storage diseases | D016464 | — | — | — | — | — | — | 1 | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 1 | 1 |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | — | — | — | 1 | 1 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.09 | — | — | — | — | 1 | 1 |
| Melanoma | D008545 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clofarabine |
| INN | clofarabine |
| Description | Clofarabine is a purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. It has a role as an antineoplastic agent and an antimetabolite. It is an organofluorine compound and a member of adenosines. |
| Classification | Small molecule |
| Drug class | antineoplastics (arabinofuranosyl derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F |
Identifiers
| PDB | — |
| CAS-ID | 123318-82-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1750 |
| ChEBI ID | 681569 |
| PubChem CID | 119182 |
| DrugBank | DB00631 |
| UNII ID | 762RDY0Y2H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE8A
PDE8A
Organism
Homo sapiens
Gene name
PDE8A
Gene synonyms
NCBI Gene ID
Protein name
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Protein synonyms
cAMP-specific cyclic nucleotide phosphodiesterase 8A
Uniprot ID
Mouse ortholog
Pde8a (18584)
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Q059P6)
Variants
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Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,941 adverse events reported
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