Clolar, Evoltra(clofarabine)
Clofarabine, Clolar, Evoltra, Ivozall (clofarabine) is a small molecule pharmaceutical. Clofarabine was first approved as Clolar on 2004-12-28. It is used to treat lymphoid leukemia in the USA. It has been approved in Europe to treat precursor cell lymphoblastic leukemia-lymphoma. The pharmaceutical is active against ribonucleoside-diphosphate reductase subunit M2. In addition, it is known to target ribonucleoside-diphosphate reductase large subunit.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Clofarabine, Clolar (discontinued: Clofarabine)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clofarabine | ANDA | 2024-02-27 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| lymphoid leukemia | — | D007945 | C91 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9027 | Injection, clofarabine, 1 mg |
Clinical
Clinical Trials
178 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 55 | 85 | 13 | — | 3 | 128 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 25 | 57 | 7 | — | 2 | 80 |
| Myeloid leukemia | D007951 | — | C92 | 26 | 53 | 7 | — | 2 | 76 |
| Myelodysplastic syndromes | D009190 | — | D46 | 25 | 37 | 3 | — | — | 52 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 18 | 34 | 5 | — | 1 | 50 |
| Preleukemia | D011289 | — | — | 21 | 32 | 2 | — | — | 42 |
| Lymphoid leukemia | D007945 | — | C91 | 18 | 21 | 4 | — | 1 | 39 |
| Syndrome | D013577 | — | — | 12 | 24 | 1 | — | — | 30 |
| Lymphoma | D008223 | — | C85.9 | 16 | 23 | 1 | — | — | 28 |
| Acute disease | D000208 | — | — | 1 | 2 | 2 | — | 1 | 5 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 8 | 15 | — | — | — | 18 |
| Hematologic neoplasms | D019337 | — | — | 11 | 8 | — | — | 2 | 17 |
| Neoplasms | D009369 | — | C80 | 13 | 7 | — | — | 1 | 17 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 4 | 10 | — | — | — | 13 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 5 | 7 | — | — | — | 11 |
| Hodgkin disease | D006689 | — | C81 | 6 | 8 | — | — | — | 10 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 6 | 5 | — | — | — | 9 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 4 | 6 | — | — | — | 9 |
| Recurrence | D012008 | — | — | 2 | 4 | — | — | 1 | 7 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 6 | — | — | — | 7 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoproliferative disorders | D008232 | Orphanet_2442 | D47.9 | 1 | — | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
| Neutropenia | D009503 | — | D70 | 1 | — | — | — | — | 1 |
| Bone marrow diseases | D001855 | — | — | 1 | — | — | — | — | 1 |
| Arteritis | D001167 | EFO_0009011 | I77.6 | 1 | — | — | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | — | — | — | — | 1 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | — | — | — | — | 1 |
| Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | 1 | — | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | — | — | — | 1 |
| Takayasu arteritis | D013625 | EFO_1001857 | M31.4 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Frailty | D000073496 | — | R53.1 | — | — | — | — | 1 | 1 |
| Peroxisomal disorders | D018901 | Orphanet_44 | E71.5 | — | — | — | — | 1 | 1 |
| Lysosomal storage diseases | D016464 | — | — | — | — | — | — | 1 | 1 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 1 | 1 |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | — | — | — | 1 | 1 |
| Fanconi anemia | D005199 | Orphanet_84 | D61.03 | — | — | — | — | 1 | 1 |
| Inborn errors metabolism | D008661 | — | — | — | — | — | — | 1 | 1 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | — | — | — | — | 1 | 1 |
| Melanoma | D008545 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clofarabine |
| INN | clofarabine |
| Description | Clofarabine is a purine nucleoside analogue consisting of a 6-amino-2-chloropurin-9-yl group attached to the 1beta position of 2'-deoxy-2'-fluoro-D-arabinofuranose. It is metabolized intracellularly to the active 5'-triphosphate metabolite, which inhibits DNA synthesisis and so stops the growth of cancer cells. Clofarabine is used as an antimetabolite antineoplastic agent in the treatment of relapsed or refractory acute lymphoblastic leukaemia. It has a role as an antineoplastic agent and an antimetabolite. It is an organofluorine compound and a member of adenosines. ... More |
| Classification | Small molecule |
| Drug class | antineoplastics (arabinofuranosyl derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F |
Identifiers
| PDB | — |
| CAS-ID | 123318-82-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1750 |
| ChEBI ID | 681569 |
| PubChem CID | 119182 |
| DrugBank | DB00631 |
| UNII ID | 762RDY0Y2H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDE8A
PDE8A
Organism
Homo sapiens
Gene name
PDE8A
Gene synonyms
NCBI Gene ID
Protein name
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Protein synonyms
cAMP-specific cyclic nucleotide phosphodiesterase 8A
Uniprot ID
Mouse ortholog
Pde8a (18584)
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Q059P6)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,257 adverse events reported
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