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AboutPricing
Drug ReportsClobetasol
Clobetasol propionate
Clobetasol, Clobex, Impoyz (clobetasol propionate) is a small molecule pharmaceutical. Clobetasol propionate was first approved as Temovate on 1985-12-27. It is used to treat dermatitis, facial dermatoses, foot dermatoses, hand dermatoses, and inflammation amongst others in the USA. The pharmaceutical is active against glucocorticoid receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Clobetasol, Clobetasol (emollient), Clobex, Impoyz (discontinued: Clobetasol, Clobetasol (emollient), Cormax, Embeline, Impeklo, Olux, Temovate)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clobetasol propionate
Tradename
Company
Number
Date
Products
CLOBETASOL PROPIONATEEyenoviaN-218158 RX2024-03-04
1 products, RLD, RS
CLOBEXGaldermaN-021644 RX2004-02-05
1 products, RLD, RS
CLOBEXGaldermaN-021535 RX2003-07-24
1 products, RLD, RS
CLOBEXGaldermaN-021835 RX2005-10-27
1 products, RLD, RS
IMPOYZPrimus PharmaceuticalsN-209483 RX2017-11-28
1 products, RLD, RS
Show 8 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
calcipotriene 0.005% / clobetasol propionate 0.05%unapproved drug other2019-05-20
ciclopirox 1% / clobetasol propionate 0.05%unapproved drug other2019-04-24
ciclopirox olamine 0.77% / clobetasol propionate 0.05% / salicylic acid 3%.unapproved drug other2019-05-16
clobetasol propionateANDA2025-03-26
clobetasol propionate (emollient)ANDA2021-07-01
clobetasol propionate 0.05% / coal tar 8% / salicylic acid 6%unapproved drug other2019-05-14
clobetasol propionate 0.05% / levocetirizine dihydrochloride 2%unapproved drug other2019-05-16
clobetasol propionate 0.05% / niacinamide 4%unapproved drug other2019-05-02
clobetasol propionate cream usp, 0.05%ANDA2024-11-08
clobetasol propionate cream, 0.05%ANDA2024-08-01
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
inflammationMP_0001845D007249—
dermatitis—D003872L30.9
facial dermatoses—D005148—
foot dermatoses—D005533—
hand dermatoses—D006229—
scalp dermatoses—D012536—
leg dermatoses—D007868—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Clobetasol Propionate, Impoyz, Primus Pharms
98553342035-03-11DP
99562312030-08-31DPU-88, U-193, U-742, U-1408, U-1761, U-1858
100648752030-08-31DPU-88, U-193, U-742, U-1408, U-1858
105889142030-08-31DPU-2771
Clobetasol Propionate, Olux E, Mylan
84606412028-11-05DPU-1410
89620002025-08-31DPU-1410
ATC Codes
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AD: Corticosteroids, very potent (group iv)
— D07AD01: Clobetasol
— D07C: Corticosteroids, combinations with antibiotics
— D07CD: Corticosteroids, very potent, combinations with antibiotics
— D07CD01: Clobetasol and antibiotics
HCPCS
No data
Clinical
Clinical Trials
132 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———3————3
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameClobetasol propionate
INNclobetasol
Description
Clobetasol propionate is the 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis. It has a role as an anti-inflammatory drug. It is an 11beta-hydroxy steroid, a 20-oxo steroid, a glucocorticoid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a chlorinated steroid. It is functionally related to a clobetasol and a propionic acid.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C
Identifiers
PDB—
CAS-ID25122-46-7
RxCUI—
ChEMBL IDCHEMBL1159650
ChEBI ID31414
PubChem CID32798
DrugBankDB01013
UNII ID779619577M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CYP3A5
CYP3A5
Organism
Homo sapiens
Gene name
CYP3A5
Gene synonyms
NCBI Gene ID
1577
Protein name
cytochrome P450 3A5
Protein synonyms
aryl hydrocarbon hydroxylase, CYPIIIA5, cytochrome P450 HLp2, cytochrome P450, family 3, subfamily A, polypeptide 5, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 5, Cytochrome P450-PCN3, flavoprotein-linked monooxygenase, microsomal monooxygenase, xenobiotic monooxygenase
Uniprot ID
Q9HB56
Mouse ortholog
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—
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Clobetasol propionate
+
Clobetasol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,836 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8,397 adverse events reported
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