Clemizole
Clemizole is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target short transient receptor potential channel 6, short transient receptor potential channel 4, short transient receptor potential channel 3, and short transient receptor potential channel 5.
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Commercial
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Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | — | — | 6 | 2 | — | 8 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | — | 1 | 3 | 2 | — | 6 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myoclonic epilepsies | D004831 | EFO_1001900 | G40.4 | 1 | — | 1 | — | — | 2 |
| Fever | D005334 | — | R50.9 | — | — | 1 | — | — | 1 |
| Seizures | D012640 | — | G40.4 | — | — | 1 | — | — | 1 |
| Lennox gastaut syndrome | D065768 | — | G40.81 | — | — | 1 | — | — | 1 |
| Syndrome | D013577 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | 1 | — | — | — | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | — | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | 1 | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | 1 | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | 1 | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | — | 1 | — | — | — | 1 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | 1 | 1 | — | — | — | 1 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 1 | — | — | — | — | 1 |
| Hepatitis | D006505 | — | K75.9 | 1 | — | — | — | — | 1 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 1 | — | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Colonic polyps | D003111 | — | K63.5 | 1 | — | — | — | — | 1 |
| Adenomatous polyps | D018256 | — | D28 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | — | — | — | 1 | 1 |
| Traumatic stress disorders | D040921 | — | — | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
| Lung neoplasms | D008175 | — | C34.90 | — | — | — | — | 1 | 1 |
| Eye abnormalities | D005124 | — | Q15.9 | — | — | — | — | 1 | 1 |
| Bone marrow examination | D001856 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clemizole |
| INN | clemizole |
| Description | Clemizole is a member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively. It has a role as a histamine antagonist. It is a member of pyrrolidines, a member of benzimidazoles and a member of monochlorobenzenes. It is a conjugate base of a clemizole(1+). It derives from a hydride of a 1H-benzimidazole. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Clc1ccc(Cn2c(CN3CCCC3)nc3ccccc32)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 442-52-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1407943 |
| ChEBI ID | 52140 |
| PubChem CID | 2782 |
| DrugBank | — |
| UNII ID | T97CB3796L (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
TRPC6
TRPC6
TRPC4
TRPC4
TRPC3
TRPC3
TRPC5
TRPC5
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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74 adverse events reported
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