Citicoline
Citicoline is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
69 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glaucoma | D005901 | EFO_0000516 | H40 | 1 | — | 2 | 1 | 8 | 12 |
| Cerebral infarction | D002544 | — | I63 | — | — | 3 | 1 | 2 | 6 |
| Ischemia | D007511 | EFO_0000556 | — | 1 | — | 2 | 1 | 2 | 6 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 2 | 1 | 1 | 1 | 5 |
| Brain injuries | D001930 | — | S06.9 | — | 2 | 1 | 1 | — | 4 |
| Optic nerve diseases | D009901 | EFO_1001330 | H47.14 | — | — | — | 2 | 2 | 4 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | 2 | 1 | 3 |
| Ischemic optic neuropathy | D018917 | EFO_1000809 | H47.01 | — | — | — | 2 | 1 | 3 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 1 | — | 2 | — | 3 |
| Cocaine-related disorders | D019970 | — | F14 | — | — | 1 | 1 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | 2 | 1 | 4 | — | 1 | 7 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | 1 | — | 1 | — | 5 | 7 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 1 | 4 | — | 1 | 6 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 1 | — | 1 | 2 |
| Hypoxia | D000860 | — | R09.02 | 1 | — | 1 | — | — | 2 |
| Brain hypoxia-ischemia | D020925 | EFO_1000846 | P91.6 | 1 | — | 1 | — | — | 2 |
| Mania | D000087122 | — | F30 | — | — | 1 | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | — | 1 | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | — | — | 1 | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 2 | — | — | — | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | 1 | 2 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 1 | — | — | 1 | 2 |
| Leukemia | D007938 | — | C95 | — | 1 | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 1 | — | — | — | 1 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | — | 1 | — | — | — | 1 |
| Monocytic leukemia acute | D007948 | — | — | — | 1 | — | — | — | 1 |
| Myelomonocytic leukemia acute | D015479 | — | C92.5 | — | 1 | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | — | 1 | — | — | — | 1 |
| Erythroblastic leukemia acute | D004915 | EFO_1001257 | C94.0 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Retinal diseases | D012164 | — | H35.9 | 1 | — | — | — | 1 | 2 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 1 | — | — | — | 1 | 2 |
| Brain diseases | D001927 | — | G93.40 | 1 | — | — | — | — | 1 |
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | — | — | 6 | 6 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | — | — | — | 2 | 2 |
| Corneal diseases | D003316 | — | H18.9 | — | — | — | — | 1 | 1 |
| Amphetamine-related disorders | D019969 | EFO_0004701 | F15 | — | — | — | — | 1 | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | — | — | 1 | 1 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | — | — | 1 | 1 |
| Visual fields | D014794 | — | — | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | — | 1 | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Citicoline |
| INN | citicoline |
| Description | CDP-choline is a member of the class of phosphocholines that is the chloine ester of CDP. It is an intermediate obtained in the biosynthetic pathway of structural phospholipids in cell membranes. It has a role as a human metabolite, a psychotropic drug, a neuroprotective agent, a Saccharomyces cerevisiae metabolite and a mouse metabolite. It is a member of phosphocholines and a member of nucleotide-(amino alcohol)s. It is functionally related to a CDP. It is a conjugate base of a CDP-choline(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)[C@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 987-78-0 |
| RxCUI | 997602 |
| ChEMBL ID | CHEMBL1618340 |
| ChEBI ID | 49086 |
| PubChem CID | 13804 |
| DrugBank | DB12153 |
| UNII ID | 536BQ2JVC7 (ChemIDplus, GSRS) |
Target
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Trends
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Safety
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Adverse Events
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153 adverse events reported
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