Citalopram
Celexa, Citalopram (citalopram) is a small molecule pharmaceutical. Citalopram was first approved as Celexa on 1998-07-17. It is used to treat alcoholism, dementia, depressive disorder, diabetic neuropathies, and obsessive-compulsive disorder amongst others in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter. In addition, it is known to target sodium-dependent noradrenaline transporter.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Celexa, Citalopram (discontinued: Celexa, Citalopram)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Citalopram hydrobromide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CELEXA | AbbVie | N-020822 RX | 1998-07-17 | 3 products, RLD, RS |
| CITALOPRAM HYDROBROMIDE | Almatica Pharma | N-215428 RX | 2022-01-31 | 1 products, RLD, RS |
Show 3 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| celexa | New Drug Application | 2023-10-09 |
| citalopram | ANDA | 2025-08-25 |
| citalopram citalopram hydrobromide | ANDA | 2023-04-19 |
| citalopram hydrobromide | ANDA | 2025-06-09 |
| direct rx | ANDA | 2015-11-06 |
| perrigo citalopram | ANDA | 2010-02-25 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
709 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 22 | 59 | 68 | 125 | 101 | 358 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 23 | 58 | 67 | 109 | 88 | 328 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 16 | 48 | 54 | 81 | 60 | 251 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | 6 | 7 | 13 | 16 | 15 | 53 |
| Healthy volunteers/patients | — | — | — | 24 | — | — | 4 | 7 | 35 |
| Anxiety | D001007 | EFO_0005230 | F41.1 | — | 1 | 5 | 6 | 8 | 19 |
| Treatment-resistant depressive disorder | D061218 | — | — | 2 | 1 | 7 | 3 | 5 | 18 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | 1 | 2 | 9 | 5 | 17 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | 2 | 4 | 5 | 5 | 16 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 3 | 9 | 3 | 15 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | 1 | 5 | 1 | — | — | 6 |
| Hot flashes | D019584 | — | — | — | — | 1 | — | 4 | 5 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | 2 | — | 1 | 4 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 2 | — | 1 | 4 |
| Fibromyalgia | D005356 | EFO_0005687 | M79.1 | — | 2 | 2 | — | 1 | 3 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 1 | — | 2 | 3 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | 1 | 1 | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | — | 2 | — | — | 2 |
| Chronic pain | D059350 | — | — | — | 1 | 1 | — | 1 | 2 |
| Fatigue | D005221 | — | R53.83 | — | 1 | 1 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 1 | — | — | 7 | 8 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | 1 | 2 | — | — | 1 | 4 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | — | 2 | 3 |
| Ischemic stroke | D000083242 | — | — | 1 | 3 | — | — | — | 3 |
| Autism spectrum disorder | D000067877 | — | F84.0 | 1 | 1 | — | — | 1 | 3 |
| Anhedonia | D059445 | — | R45.84 | 1 | 1 | — | — | 2 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | 1 | 2 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | 1 | — | — | 1 | 2 |
| Menopause | D008593 | EFO_0003922 | N95 | — | 1 | — | — | 1 | 2 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | 1 | — | — | 1 | 2 |
Show 23 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal cord injuries | D013119 | EFO_1001919 | — | 2 | — | — | — | 1 | 3 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | 1 | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | 1 | 2 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 2 | — | — | — | — | 2 |
| Respiratory insufficiency | D012131 | — | J96.9 | 2 | — | — | — | — | 2 |
| Psychological stress | D013315 | — | — | 1 | — | — | — | — | 1 |
| Psychological well-being | D000092862 | — | — | 1 | — | — | — | — | 1 |
| Urinary incontinence | D014549 | — | R32 | 1 | — | — | — | — | 1 |
| Stress urinary incontinence | D014550 | — | — | 1 | — | — | — | — | 1 |
| Fecal incontinence | D005242 | — | R15 | 1 | — | — | — | — | 1 |
Show 5 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 5 | 5 |
| Taste disorders | D013651 | — | — | — | — | — | — | 3 | 3 |
| Cognition | D003071 | EFO_0003925 | — | — | — | — | — | 3 | 3 |
| Pharmacokinetics | D010599 | — | — | — | — | — | — | 2 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 2 | 2 |
| Adolescent development | D041923 | — | — | — | — | — | — | 2 | 2 |
| Affective symptoms | D000342 | — | — | — | — | — | — | 2 | 2 |
| Perimenopause | D047648 | — | — | — | — | — | — | 1 | 1 |
| Intractable pain | D010148 | — | — | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
Show 48 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Citalopram |
| INN | citalopram |
| Description | 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile is a nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group. It is a member of 2-benzofurans, a nitrile, an organofluorine compound, a cyclic ether and a tertiary amino compound. It is a conjugate base of a 3-[5-cyano-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-1-yl]-N,N-dimethylpropan-1-aminium. |
| Classification | Small molecule |
| Drug class | Selective serotonin reuptake inhibitor (SSRI) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21 |
Identifiers
| PDB | — |
| CAS-ID | 59729-33-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL549 |
| ChEBI ID | 77397 |
| PubChem CID | 2771 |
| DrugBank | DB00215 |
| UNII ID | 0DHU5B8D6V (ChemIDplus, GSRS) |
Target
Agency Approved
SLC6A4
SLC6A4
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Alternate
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A2
Gene synonyms
NAT1, NET1, SLC6A5
NCBI Gene ID
Protein name
sodium-dependent noradrenaline transporter
Protein synonyms
NET, neurotransmitter transporter, Norepinephrine transporter, solute carrier family 6 (neurotransmitter transporter), member 2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, solute carrier family 6 member 5
Uniprot ID
Mouse ortholog
Slc6a2 (20538)
sodium-dependent noradrenaline transporter (Q6QU62)
Variants
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Financial
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Estimated US medical usage
Citalopram
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 22,681 documents
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Safety
Black-box Warning
Black-box warning for: Celexa, Citalopram, Citalopram citalopram hydrobromide, Citalopram hydrobromide, Direct rx
Adverse Events
Top Adverse Reactions
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86,843 adverse events reported
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