Cisplatin
Platinol, Platinol-aq (cisplatin) is a small molecule pharmaceutical. Cisplatin was first approved as Cisplatin on 1982-01-01. It is used to treat amelanotic melanoma, astrocytoma, breast neoplasms, cystic mesothelioma, and esophageal neoplasms amongst others in the USA.
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cisplatin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CISPLATIN | HQ Specialty Pharma | N-018057 RX | 1982-01-01 | 2 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cisplatin | ANDA | 2024-02-12 |
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| J9060 | Injection, cisplatin, powder or solution, 10 mg |
Clinical
Clinical Trials
4414 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 114 | 332 | 178 | 20 | 34 | 622 |
| Head and neck neoplasms | D006258 | — | — | 68 | 166 | 61 | 2 | 19 | 285 |
| Neoplasms | D009369 | — | C80 | 148 | 76 | 21 | 1 | 13 | 229 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 60 | 121 | 46 | 2 | 17 | 225 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 40 | 85 | 71 | 1 | 28 | 212 |
| Esophageal neoplasms | D004938 | — | C15 | 26 | 110 | 47 | 5 | 19 | 186 |
| Urinary bladder neoplasms | D001749 | — | C67 | 30 | 97 | 27 | 2 | 11 | 152 |
| Small cell lung carcinoma | D055752 | — | — | 23 | 53 | 28 | 2 | 11 | 107 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | 7 | 69 | 28 | 1 | 6 | 105 |
| Squamous cell carcinoma | D002294 | — | — | 28 | 58 | 18 | 1 | 4 | 97 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 52 | 133 | 61 | — | 13 | 232 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 45 | 125 | 53 | — | 14 | 213 |
| Nasopharyngeal neoplasms | D009303 | — | — | 12 | 95 | 74 | — | 18 | 185 |
| Nasopharyngeal carcinoma | D000077274 | — | — | 9 | 79 | 75 | — | 17 | 169 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 45 | 65 | 26 | — | 10 | 131 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 26 | 79 | 11 | — | 8 | 110 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 31 | 62 | 7 | — | 2 | 86 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 21 | 41 | 15 | — | 4 | 71 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 16 | 51 | 11 | — | 2 | 67 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 6 | 34 | 19 | — | 12 | 64 |
Show 121 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hearing loss | D034381 | EFO_0004238 | H91.9 | 2 | 5 | — | — | 4 | 10 |
| Uterine neoplasms | D014594 | EFO_0003859 | C55 | — | 5 | — | — | 2 | 7 |
| Thymus neoplasms | D013953 | — | C37 | 2 | 5 | — | — | — | 6 |
| Colonic neoplasms | D003110 | — | C18 | 3 | 4 | — | — | — | 6 |
| Penile neoplasms | D010412 | — | C60 | 1 | 5 | — | — | — | 6 |
| Brenner tumor | D001948 | — | — | 3 | 1 | — | — | 1 | 5 |
| Papillomaviridae | D027383 | — | — | — | 4 | — | — | 1 | 5 |
| B-cell lymphoma | D016393 | — | — | 4 | 2 | — | — | — | 5 |
| Cystadenocarcinoma | D003536 | — | — | 2 | 1 | — | — | 1 | 4 |
| Digestive system neoplasms | D004067 | — | — | 2 | 3 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Appendiceal neoplasms | D001063 | EFO_0003880 | C18.1 | 2 | — | — | — | 2 | 4 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | 3 | 4 |
| Rhabdomyosarcoma | D012208 | — | — | 2 | — | — | — | — | 2 |
| Desmoplastic small round cell tumor | D058405 | — | — | 2 | — | — | — | — | 2 |
| Hydronephrosis | D006869 | EFO_0005562 | N13.30 | 1 | — | — | — | — | 1 |
| Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
| Pinealoma | D010871 | — | — | 1 | — | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
| Medical sociology | D012962 | — | — | 1 | — | — | — | — | 1 |
| Neurotoxicity syndromes | D020258 | — | G92 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Circulating neoplastic cells | D009360 | — | — | — | — | — | — | 2 | 2 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 2 | 2 |
| Cervical intraepithelial neoplasia | — | — | D06 | — | — | — | — | 2 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 2 | 2 |
| Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | — | — | — | 1 | 1 |
| Multiple primary neoplasms | D009378 | — | — | — | — | — | — | 1 | 1 |
| Dna damage | D004249 | — | — | — | — | — | — | 1 | 1 |
| Double-stranded dna breaks | D053903 | — | — | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Pleural effusion | D010996 | HP_0002202 | J90 | — | — | — | — | 1 | 1 |
Show 25 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cisplatin |
| INN | cisplatin |
| Description | Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein.
|
| Classification | Small molecule |
| Drug class | antineoplastics (platinum derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 15663-27-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL11359 |
| ChEBI ID | — |
| PubChem CID | 5702198 |
| DrugBank | DB00515 |
| UNII ID | Q20Q21Q62J (ChemIDplus, GSRS) |
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Additional graphs summarizing 212,625 documents
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Safety
Black-box Warning
Black-box warning for: Cisplatin
Adverse Events
Top Adverse Reactions
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52,866 adverse events reported
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