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Drug ReportsCisatracurium
Cisatracurium
Cisatracurium Besylate (cisatracurium) is a small molecule pharmaceutical. Cisatracurium was first approved as Nimbex on 1995-12-15.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Brand Name
Status
Last Update
cisatracuriumANDA2025-02-21
cisatracurium besylateANDA2025-05-15
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Agency Specific
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ATC Codes
M: Musculo-skeletal system drugs
M03: Muscle relaxants
M03A: Muscle relaxants, peripherally acting agents
M03AC: Other quaternary ammonium compounds in atc, muscle relaxants, peripherally acting
M03AC11: Cisatracurium
HCPCS
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Clinical
Clinical Trials
148 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
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Other
Total
Neuromuscular blockadeD019148112
Indications Phases 3
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MeSH
Ontology
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General anesthesiaD00076811
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCisatracurium
INNcisatracurium besilate
Description
Cisatracurium besylate is the (1R,1'R,2R,2'R)-diastereoisomer of atracurium besylate. Commercial preparations of atracurium are mixtures of 10 stereoisomers, of which cisatracurium generally constitutes about 15%. Cisatracurium besylate is about 3 times more potent than the mixture of atracurium isomers as a neuromuscular blocking agent, and is used as a muscle relaxant for endotracheal intubation, to aid controlled ventilation, and in general anaesthesia. It has a role as a muscle relaxant and a nicotinic antagonist. It is a quaternary ammonium salt, an atracurium besylate and an organosulfonate salt. It contains a cisatracurium.
Classification
Small molecule
Drug classquaternary ammonium derivatives: neuromuscular blocking agents
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Structure (InChI/SMILES or Protein Sequence)
COc1ccc(C[C@@H]2c3cc(OC)c(OC)cc3CC[N@+]2(C)CCC(=O)OCCCCCOC(=O)CC[N@@+]2(C)CCc3cc(OC)c(OC)cc3[C@H]2Cc2ccc(OC)c(OC)c2)cc1OC
Identifiers
PDB
CAS-ID96946-41-7
RxCUI
ChEMBL IDCHEMBL1201248
ChEBI ID
PubChem CID62886
DrugBankDB00565
UNII ID80YS8O1MBS (ChemIDplus, GSRS)
Target
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Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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2,189 adverse events reported
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