Cisatracurium
Cisatracurium Besylate (cisatracurium) is a small molecule pharmaceutical. Cisatracurium was first approved as Nimbex on 1995-12-15.
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Brand Name | Status | Last Update |
|---|---|---|
| cisatracurium | ANDA | 2021-06-09 |
| cisatracurium besylate | ANDA | 2024-08-29 |
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Clinical Trials
146 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuromuscular blockade | D019148 | — | — | — | 1 | — | 7 | 9 | 17 |
| Acute lung injury | D055371 | EFO_0004610 | — | 1 | 2 | 2 | 3 | 6 | 14 |
| Anesthesia | D000758 | — | — | — | — | — | 6 | 8 | 14 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | 2 | 2 | 3 | 5 | 13 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | 1 | 2 | 2 | 3 | 5 | 13 |
| General anesthesia | D000768 | — | — | — | — | 1 | 2 | 8 | 11 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | 3 | 4 | 7 |
| Emergence delirium | D000071257 | — | — | 1 | — | — | 2 | 4 | 7 |
| Delirium | D003693 | — | R41.0 | 1 | — | — | 1 | 4 | 6 |
| Delayed emergence from anesthesia | D055191 | — | — | — | — | — | 4 | 2 | 6 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fasciculation | D005207 | — | R25.3 | — | — | 2 | — | 1 | 3 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 1 | — | 1 | 2 |
| Meningioma | D008579 | EFO_0003098 | D32.9 | — | — | 1 | — | — | 1 |
| Myalgia | D063806 | HP_0003326 | M79.1 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscle hypotonia | D009123 | HP_0001319 | — | — | 1 | — | — | 3 | 4 |
| Hypothermia | D007035 | HP_0002045 | T68 | — | 2 | — | — | 2 | 4 |
| Covid-19 | D000086382 | — | — | — | 1 | — | — | 2 | 3 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | 1 | — | — | — | 1 |
| Spondylolisthesis | D013168 | EFO_0007493 | M43.1 | — | 1 | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | — | — | — | 1 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | 1 | — | — | — | 1 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | 1 | — | — | — | 1 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | — | 1 | — | — | — | 1 |
| Intraocular pressure | D007429 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypoxia | D000860 | HP_0012418 | R09.02 | 1 | — | — | — | 1 | 2 |
| Femur head necrosis | D005271 | — | — | 1 | — | — | — | — | 1 |
| Necrosis | D009336 | — | — | 1 | — | — | — | — | 1 |
| Respiratory tract diseases | D012140 | — | — | 1 | — | — | — | — | 1 |
| Respiration disorders | D012120 | — | J00-J99 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intravenous anesthesia | D000771 | — | — | — | — | — | — | 6 | 6 |
| Intratracheal intubation | D007442 | — | — | — | — | — | — | 3 | 3 |
| Epidural anesthesia | D000767 | — | — | — | — | — | — | 2 | 2 |
| Aortic dissection | D000784 | — | I71.0 | — | — | — | — | 2 | 2 |
| Conduction anesthesia | D000765 | — | — | — | — | — | — | 2 | 2 |
| Thoracic surgical procedures | D019616 | — | — | — | — | — | — | 2 | 2 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 2 | 2 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 2 | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 2 | 2 |
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cisatracurium |
| INN | cisatracurium besilate |
| Description | Cisatracurium besylate is the (1R,1'R,2R,2'R)-diastereoisomer of atracurium besylate. Commercial preparations of atracurium are mixtures of 10 stereoisomers, of which cisatracurium generally constitutes about 15%. Cisatracurium besylate is about 3 times more potent than the mixture of atracurium isomers as a neuromuscular blocking agent, and is used as a muscle relaxant for endotracheal intubation, to aid controlled ventilation, and in general anaesthesia. It has a role as a muscle relaxant and a nicotinic antagonist. It is a quaternary ammonium salt, an atracurium besylate and an organosulfonate salt. It contains a cisatracurium. |
| Classification | Small molecule |
| Drug class | quaternary ammonium derivatives: neuromuscular blocking agents |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(C[C@@H]2c3cc(OC)c(OC)cc3CC[N@+]2(C)CCC(=O)OCCCCCOC(=O)CC[N@@+]2(C)CCc3cc(OC)c(OC)cc3[C@H]2Cc2ccc(OC)c(OC)c2)cc1OC |
Identifiers
| PDB | — |
| CAS-ID | 96946-41-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201248 |
| ChEBI ID | — |
| PubChem CID | 62886 |
| DrugBank | DB00565 |
| UNII ID | 80YS8O1MBS (ChemIDplus, GSRS) |
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Safety
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2,028 adverse events reported
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