Sensipar, Mimpara(cinacalcet)
Cinacalcet, Mimpara, Sensipar (cinacalcet) is a small molecule pharmaceutical. Cinacalcet was first approved as Sensipar on 2004-03-08. It is used to treat parathyroid neoplasms, primary hyperparathyroidism, and secondary hyperparathyroidism in the USA. It has been approved in Europe to treat hypercalcemia, hyperparathyroidism, parathyroid neoplasms, and secondary hyperparathyroidism. The pharmaceutical is active against extracellular calcium-sensing receptor. In addition, it is known to target metabotropic glutamate receptor 5.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Cinacalcet, Sensipar (discontinued: Cinacalcet)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cinacalcet | ANDA | 2024-09-26 |
| cinacalcet hydrochloride | ANDA | 2024-05-24 |
| sensipar | New Drug Application | 2024-02-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| parathyroid neoplasms | — | D010282 | — |
| secondary hyperparathyroidism | EFO_1001173 | D006962 | — |
| primary hyperparathyroidism | EFO_0008519 | D049950 | E21.0 |
Agency Specific
FDA
EMA
No data
HCPCS
Code | Description |
|---|---|
| J0604 | Cinacalcet, oral, 1 mg, (for esrd on dialysis) |
Clinical
Clinical Trials
83 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | 2 | 15 | 22 | 19 | 7 | 61 |
| Secondary hyperparathyroidism | D006962 | EFO_1001173 | — | 2 | 10 | 15 | 15 | 5 | 44 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 9 | 13 | 11 | 1 | 33 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 7 | 11 | 8 | 1 | 27 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 4 | 9 | 7 | 1 | 21 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | — | 6 | 5 | 3 | 2 | 16 |
| Primary hyperparathyroidism | D049950 | EFO_0008519 | E21.0 | — | 5 | 5 | 2 | 3 | 14 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 2 | — | 1 | 1 | 4 |
| Parathyroid neoplasms | D010282 | — | — | — | — | 2 | 1 | — | 3 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | — | 2 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypercalcemia | D006934 | HP_0003072 | E83.52 | 1 | 1 | 3 | — | — | 4 |
| Kidney transplantation | D016030 | — | — | — | — | 1 | — | 3 | 4 |
| Hypophosphatemia | D017674 | HP_0002148 | — | 1 | — | 1 | — | 1 | 3 |
| Adenoma | D000236 | — | — | — | — | 1 | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | — | 1 | — | — | 1 |
| Parathyroid diseases | D010279 | — | E21.5 | — | — | 1 | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic kidney disease-mineral and bone disorder | D012080 | EFO_1001152 | N25.0 | — | 2 | — | — | 1 | 3 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
| Insulin resistance | D007333 | HP_0000855 | — | — | 1 | — | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | — | 1 |
| Bone diseases | D001847 | — | M89.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 1 | 2 |
| Familial hypophosphatemic rickets | D053098 | — | — | 1 | — | — | — | 1 | 2 |
| Hypophosphatemic rickets | D063730 | — | E83.31 | 1 | — | — | — | 1 | 2 |
| Rickets | D012279 | HP_0002748 | E55.0 | 1 | — | — | — | 1 | 2 |
| Osteomalacia | D010018 | EFO_1002027 | M83 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Calcium metabolism disorders | D002128 | EFO_0005769 | E83.5 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cinacalcet |
| INN | cinacalcet |
| Description | Cinacalcet is a secondary amino compound that is (1R)-1-(naphthalen-1-yl)ethanamine in which one of the hydrogens attached to the nitrogen is substituted by a 3-[3-(trifluoromethyl)phenyl]propyl group. It has a role as a calcimimetic and a P450 inhibitor. It is a member of naphthalenes, a secondary amino compound and a member of (trifluoromethyl)benzenes. |
| Classification | Small molecule |
| Drug class | calcium-sensing receptor (CaSR) agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](NCCCc1cccc(C(F)(F)F)c1)c1cccc2ccccc12 |
Identifiers
| PDB | — |
| CAS-ID | 226256-56-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201284 |
| ChEBI ID | 48390 |
| PubChem CID | 156419 |
| DrugBank | DB01012 |
| UNII ID | UAZ6V7728S (ChemIDplus, GSRS) |
Target
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GRM5
GRM5
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Cinacalcet
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Trends
PubMed Central
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Additional graphs summarizing 3,992 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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45,742 adverse events reported
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