Cimetidine
Cimetidine, Tagamet (cimetidine) is a small molecule pharmaceutical. Cimetidine was first approved as Tagamet on 1982-01-01. It is used to treat duodenal ulcer, dyspepsia, gastroesophageal reflux, heartburn, and helicobacter infections amongst others in the USA. The pharmaceutical is active against histamine H2 receptor. In addition, it is known to target multidrug and toxin extrusion protein 2, equilibrative nucleoside transporter 4, and multidrug and toxin extrusion protein 1.
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Commercial
Trade Name
FDA
EMA
Cimetidine, Tagamet (discontinued: Cimetidine, Tagamet)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cimetidine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TAGAMET HB | MedTech Products | N-020238 OTC | 1996-08-21 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| basic care acid reducer | ANDA | 2022-01-14 |
| cimetidine | ANDA | 2024-10-10 |
| cimetidine 10% / lidocaine 5% / salicylic acid 40% | unapproved drug other | 2019-04-24 |
| cimetidine 5% / ibuprofen 2% / salicylic acid 17% | unapproved drug other | 2019-05-17 |
| cimetidine hydrochloride | ANDA | 2024-10-22 |
| cimetidine hydrochloride oral solution | ANDA | 2022-10-17 |
| equate cimetidine | ANDA | 2022-03-10 |
| good neighbor pharmacy heartburn relief | ANDA | 2020-02-04 |
| good sense heartburn relief | ANDA | 2020-02-04 |
| heartburn prevention | ANDA | 2022-11-14 |
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| S0023 | Injection, cimetidine hydrochloride, 300 mg |
Clinical
Clinical Trials
148 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 1 | 1 | 2 | 34 | 38 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | 1 | 2 | 24 | 27 |
| Healthy volunteers/patients | — | — | — | 7 | — | — | 1 | — | 8 |
| Edentulous jaw partially | D007576 | — | — | — | — | — | 1 | 2 | 3 |
| Edentulous jaw | D007575 | — | — | — | — | — | 1 | 2 | 3 |
| Respiratory aspiration of gastric contents | D063466 | — | — | — | — | — | 1 | — | 1 |
| Plantar fasciitis | D036981 | EFO_1001909 | M72.2 | — | — | — | 1 | — | 1 |
| Fasciitis | D005208 | HP_0100537 | M72.9 | — | — | — | 1 | — | 1 |
| Postpartum period | D049590 | — | — | — | — | — | 1 | — | 1 |
| Lactation | D007774 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | 1 | 2 | — | 10 | 12 |
| Femoral neck fractures | D005265 | EFO_1001792 | S72.00 | — | 1 | 2 | — | 1 | 3 |
| Prosthesis-related infections | D016459 | EFO_1001406 | — | — | — | 1 | — | 2 | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 1 | — | — | 2 |
| Ulcer | D014456 | MPATH_579 | — | — | — | 2 | — | — | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 2 | — | — | 2 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | — | — | 1 | — | — | 1 |
| Hyperlipoproteinemias | D006951 | HP_0010980 | — | — | — | 1 | — | — | 1 |
| Peptic ulcer | D010437 | HP_0004398 | K27 | — | — | 1 | — | — | 1 |
| Peptic ulcer hemorrhage | D010438 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | 1 | 4 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | 3 | 4 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | 1 | — | — | 3 | 4 |
| Triple negative breast neoplasms | D064726 | — | — | — | 1 | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | — | 1 | — | — | — | 1 |
| Serous cystadenocarcinoma | D018284 | — | — | — | 1 | — | — | — | 1 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | 1 | — | — | — | 1 |
| Gastritis | D005756 | EFO_0000217 | K29.7 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 1 | — | — | — | — | 1 |
| Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Myelomonocytic leukemia juvenile | D054429 | — | C93.3 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Necrosis | D009336 | — | — | — | — | — | — | 7 | 7 |
| Osteonecrosis | D010020 | EFO_0004259 | M87 | — | — | — | — | 6 | 6 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 5 | 5 |
| Replacement arthroplasty knee | D019645 | — | — | — | — | — | — | 5 | 5 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | — | — | 4 | 4 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 4 | 4 |
| Joint diseases | D007592 | HP_0003040 | M12.9 | — | — | — | — | 4 | 4 |
| Infections | D007239 | EFO_0000544 | — | — | — | — | — | 3 | 3 |
| Communicable diseases | D003141 | — | — | — | — | — | — | 3 | 3 |
| Femoral fractures | D005264 | — | S72 | — | — | — | — | 3 | 3 |
Show 86 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cimetidine |
| INN | cimetidine |
| Description | Cimetidine is a member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach. It has a role as a H2-receptor antagonist, a P450 inhibitor, an anti-ulcer drug, an analgesic and an adjuvant. It is a member of guanidines, a member of imidazoles, an aliphatic sulfide and a nitrile. |
| Classification | Small molecule |
| Drug class | H2-receptor antagonists (cimetidine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN/C(=N\CCSCc1nc[nH]c1C)NC#N |
Identifiers
| PDB | — |
| CAS-ID | 51481-61-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL30 |
| ChEBI ID | 3699 |
| PubChem CID | 2756 |
| DrugBank | DB00501 |
| UNII ID | 80061L1WGD (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
SLC47A2
SLC47A2
Organism
Homo sapiens
Gene name
SLC47A2
Gene synonyms
MATE2
NCBI Gene ID
Protein name
multidrug and toxin extrusion protein 2
Protein synonyms
Kidney-specific H(+)/organic cation antiporter, solute carrier family 47 (multidrug and toxin extrusion), member 2, Solute carrier family 47 member 2
Uniprot ID
Mouse ortholog
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—
Variants
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Financial
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Estimated US medical usage
Cimetidine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 14,072 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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4,949 adverse events reported
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