Vistide(cidofovir)
Vistide (cidofovir) is a small molecule pharmaceutical. Cidofovir was first approved as Vistide on 1996-06-26. It is used to treat aids-related opportunistic infections, cytomegalovirus infections, and cytomegalovirus retinitis in the USA. It has been approved in Europe to treat cytomegalovirus retinitis.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| eye diseases | D005128 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cidofovir
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VISTIDE | Gilead Sciences | N-020638 DISCN | 1996-06-26 | 1 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cidofovir | ANDA | 2021-04-15 |
| cidofovir dihydrate | ANDA | 2023-10-25 |
| vistide | New Drug Application | 2013-09-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| cytomegalovirus infections | EFO_0001062 | D003586 | B25 |
| aids-related opportunistic infections | — | D017088 | — |
| cytomegalovirus retinitis | EFO_1001302 | D017726 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0740 | Injection, cidofovir, 375 mg |
Clinical
Clinical Trials
42 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 3 | 2 | 1 | 5 | 13 |
| Cytomegalovirus retinitis | D017726 | EFO_1001302 | — | 1 | 3 | 2 | 2 | 4 | 11 |
| Retinitis | D012173 | — | H30.9 | 1 | 3 | 2 | 2 | 4 | 11 |
| Respiratory tract infections | D012141 | — | J06.9 | — | 1 | — | 1 | 2 | 4 |
| Papillomavirus infections | D030361 | — | — | — | 1 | 1 | 1 | 1 | 4 |
| Papilloma | D010212 | — | — | 1 | 1 | — | 1 | 1 | 4 |
| Recurrence | D012008 | — | — | — | 1 | — | 1 | 1 | 3 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 2 | 1 | 2 | — | 1 | 6 |
| Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | 1 | 1 | 2 | — | 1 | 5 |
| Communicable diseases | D003141 | — | — | 1 | 1 | 1 | — | 1 | 4 |
| Herpes simplex | D006561 | — | B00 | 1 | — | 1 | — | 2 | 4 |
| Cytomegalovirus | D003587 | — | — | — | — | 2 | — | 1 | 3 |
| Neoplasms | D009369 | — | C80 | 1 | — | 1 | — | 1 | 3 |
| Squamous intraepithelial lesions of the cervix | D065310 | — | — | — | 2 | 1 | — | — | 3 |
| Carcinoma in situ | D002278 | — | D09.9 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adenoviridae infections | D000257 | EFO_1001259 | B34.0 | — | 3 | — | — | 1 | 4 |
| Adenoviridae | D000256 | — | — | — | 2 | — | — | 1 | 3 |
| Cystitis | D003556 | EFO_1000025 | N30 | 1 | 1 | — | — | 1 | 3 |
| Hemorrhagic cystitis | D000096722 | — | — | 1 | 1 | — | — | 1 | 3 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | 1 | — | — | 1 | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | 1 | 2 |
| Precancerous conditions | D011230 | — | — | 1 | 1 | — | — | — | 2 |
| Viremia | D014766 | — | B34.9 | — | 1 | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | — | 1 | — | — | — | 1 |
| Warts | D014860 | — | B07 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | 3 | — | — | — | — | 3 |
| Hematopoietic stem cell transplantation | D018380 | — | — | 1 | — | — | — | — | 1 |
| Cervical intraepithelial neoplasia | — | — | D06 | 1 | — | — | — | — | 1 |
| Uterine cervical dysplasia | D002578 | EFO_1000910 | N87 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Condylomata acuminata | D003218 | EFO_0007147 | A63.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Papillomaviridae | D027383 | — | — | — | — | — | — | 1 | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | — | 1 | 1 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 1 | 1 |
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 1 | 1 |
| Neutropenia | D009503 | — | D70 | — | — | — | — | 1 | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cidofovir |
| INN | cidofovir |
| Description | Cidofovir anhydrous is cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. It has a role as an antiviral drug, an antineoplastic agent, an anti-HIV agent and a photosensitizing agent. It is a pyrimidone and a member of phosphonic acids. It is a conjugate acid of a cidofovir(2-) and a cidofovir(1-). |
| Classification | Small molecule |
| Drug class | antivirals |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ccn(C[C@@H](CO)OCP(=O)(O)O)c(=O)n1 |
Identifiers
| PDB | — |
| CAS-ID | 113852-37-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL152 |
| ChEBI ID | 3696 |
| PubChem CID | 60613 |
| DrugBank | DB00369 |
| UNII ID | 768M1V522C (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 6,231 documents
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Safety
Black-box Warning
Black-box warning for: Cidofovir, Cidofovir dihydrate, Vistide
Adverse Events
Top Adverse Reactions
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890 adverse events reported
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