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AboutPricing
Drug ReportsCiclopirox
Ciclopirox
Ciclopirox, Loprox (ciclopirox) is a small molecule pharmaceutical. Ciclopirox was first approved as Loprox on 1982-12-30. It is used to treat cutaneous candidiasis, onychomycosis, tinea pedis, and tinea versicolor in the USA. It is known to target poly [ADP-ribose] polymerase 1.
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Financial
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Ciclopirox, Loprox (discontinued: Ciclopirox, Loprox, Penlac)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ciclopirox
Tradename
Company
Number
Date
Products
LOPROXMedimetriks PharmaceuticalsN-018748 RX1982-12-30
1 products, RLD, RS
LOPROXMedimetriks PharmaceuticalsN-019824 RX1988-12-30
1 products, RLD, RS
Show 3 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
ciclodanANDA2020-12-21
ciclopiroxANDA2025-09-16
ciclopirox 0.77% / salicylic acid 2%unapproved drug other2019-05-16
ciclopirox 1% / clobetasol propionate 0.05%unapproved drug other2019-04-24
ciclopirox 3%unapproved drug other2019-05-20
ciclopirox 3% / itraconazole 5% / urea 20%unapproved drug other2019-05-20
ciclopirox 8% / fluconazole 1% / terbinafine hcl 1%unapproved drug other2019-04-24
ciclopirox olamineANDA2025-08-29
ciclopirox olamine 0.77% / clobetasol propionate 0.05% / salicylic acid 3%.unapproved drug other2019-05-16
ciclopirox olamine 1% / salicylic acid 2%unapproved drug other2019-05-22
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
onychomycosis—D014009B35.1
tinea pedisEFO_0007512D014008B35.3
tinea versicolorEFO_0007439D014010B36.0
cutaneous candidiasis—D002179—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D01: Antifungals for dermatological use
— D01A: Antifungals for topical use
— D01AE: Other antifungals for topical use in atc
— D01AE14: Ciclopirox
G: Genito urinary system and sex hormones
— G01: Gynecological antiinfectives and antiseptics
— G01A: Antiinfectives and antiseptics, excl. combinations with corticosteroids
— G01AX: Other gynecological antiinfectives and antiseptics in atc
— G01AX12: Ciclopirox
HCPCS
No data
Clinical
Clinical Trials
20 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
TineaD014005EFO_0007510B35.4——1—12
Tinea pedisD014008EFO_0007512B35.3——1—12
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCiclopirox
INNciclopirox
Description
Ciclopirox is a cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections. It has a role as an antibacterial agent and an antiseborrheic. It is a pyridone, a cyclic hydroxamic acid and a hydroxypyridone antifungal drug.
Classification
Small molecule
Drug classantimycotics (pyridone derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1cc(C2CCCCC2)n(O)c(=O)c1
Identifiers
PDB—
CAS-ID29342-05-0
RxCUI—
ChEMBL IDCHEMBL1413
ChEBI ID453011
PubChem CID2749
DrugBankDB01188
UNII ID19W019ZDRJ (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PARP1
PARP1
Organism
Homo sapiens
Gene name
PARP1
Gene synonyms
ADPRT, PPOL
NCBI Gene ID
142
Protein name
poly [ADP-ribose] polymerase 1
Protein synonyms
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase), ADP-ribosyltransferase diphtheria toxin-like 1, ADP-ribosyltransferase NAD(+), ADPRT 1, ARTD1, DNA ADP-ribosyltransferase PARP1, NAD(+) ADP-ribosyltransferase 1, poly (ADP-ribose) polymerase family, member 1, poly(ADP-ribose) synthetase, poly(ADP-ribosyl)transferase, Poly[ADP-ribose] synthase 1, Protein poly-ADP-ribosyltransferase PARP1
Uniprot ID
Q8IUZ9
Mouse ortholog
Parp1 (11545)
poly [ADP-ribose] polymerase 1 (P11103)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Ciclopirox
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,204 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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956 adverse events reported
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