Chlorzoxazone
Chlorzoxazone (chlorzoxazone) is a small molecule pharmaceutical. Chlorzoxazone was first approved as Paraflex on 1982-01-01. It is used to treat muscle cramp, muscle rigidity, myositis, pain, and spasm in the USA. It is known to target intermediate conductance calcium-activated potassium channel protein 4 and small conductance calcium-activated potassium channel protein 2.
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Commercial
Trade Name
FDA
EMA
Chlorzoxazone (discontinued: Chlorzoxazone, Paraflex, Parafon, Strifon)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorzoxazone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PARAFON FORTE DSC | Johnson & Johnson | N-011529 DISCN | 1987-06-15 | 1 products, RLD |
| PARAFLEX | Johnson & Johnson | N-011300 DISCN | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| chlorzoxazone | ANDA | 2025-09-24 |
| parafon dsc | ANDA | 2010-02-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| myositis | EFO_0000783 | D009220 | G72.49 |
| pain | EFO_0003843 | D010146 | R52 |
| muscle cramp | — | D009120 | — |
| spasm | — | D013035 | M62.83 |
| muscle rigidity | — | D009127 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
— M03: Muscle relaxants
— M03B: Muscle relaxants, centrally acting agents
— M03BB: Oxazol, thiazine, and triazine derivatives centrally acting muscle relaxants
— M03BB03: Chlorzoxazone
— M03BB53: Chlorzoxazone, combinations excl. psycholeptics
— M03BB73: Chlorzoxazone, combinations with psycholeptics
HCPCS
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Clinical
Clinical Trials
10 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | — | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | — | — | 1 | — | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | 1 | — | 1 |
| Hip osteoarthritis | D015207 | EFO_1000786 | M16 | — | — | — | 1 | — | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | 1 | — | 1 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | — | — | 1 | — | 1 |
| Bruxism | D002012 | — | F45.8 | — | — | — | 1 | — | 1 |
| Facial pain | D005157 | — | R51.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Bariatric surgery | D050110 | — | — | — | — | — | — | 1 | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | — | — | — | 1 | 1 |
| Smoking cessation | D016540 | EFO_0004319 | — | — | — | — | — | 1 | 1 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Chlorzoxazone |
| INN | chlorzoxazone |
| Description | Chlorzoxazone is a member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm. It has a role as a muscle relaxant and a sedative. It is a member of 1,3-benzoxazoles, an organochlorine compound and a heteroaryl hydroxy compound. |
| Classification | Small molecule |
| Drug class | Skeletal muscle relaxants |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1[nH]c2cc(Cl)ccc2o1 |
Identifiers
| PDB | — |
| CAS-ID | 95-25-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1371 |
| ChEBI ID | 3655 |
| PubChem CID | 2733 |
| DrugBank | DB00356 |
| UNII ID | H0DE420U8G (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNN2
KCNN2
Organism
Homo sapiens
Gene name
KCNN2
Gene synonyms
NCBI Gene ID
Protein name
small conductance calcium-activated potassium channel protein 2
Protein synonyms
apamin-sensitive small-conductance Ca2+-activated potassium channel, KCa2.2, potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, small conductance calcium-activated potassium channel 2
Uniprot ID
Mouse ortholog
Kcnn2 (140492)
small conductance calcium-activated potassium channel protein 2 (P58390)
Variants
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Financial
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Estimated US medical usage
Chlorzoxazone
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Trends
PubMed Central
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Additional graphs summarizing 1,685 documents
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Safety
Black-box Warning
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Adverse Events
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568 adverse events reported
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