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Drug ReportsChlorthalidone
Chlorthalidone
Chlorthalidone, Clorpres, Combipres, Demi-regroton, Edarbyclor, Kerledex, Lopressidone, Regroton, Tenoretic, Thalitone (chlorthalidone) is a small molecule pharmaceutical. Chlorthalidone was first approved as Hygroton on 1982-01-01. It is used to treat edema, glomerulonephritis, heart failure, hypertension, and liver cirrhosis amongst others in the USA. The pharmaceutical is active against carbonic anhydrase 7. In addition, it is known to target carbonic anhydrase 14, carbonic anhydrase 1, carbonic anhydrase 12, and carbonic anhydrase 4.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Thalitone (generic drugs available since 1982-01-01, discontinued: Hygroton)
Combinations
Edarbyclor, Tenoretic (generic drugs available since 1982-01-01, discontinued: Clorpres, Combipres, Demi-regroton, Kerledex, Lopressidone, Regroton)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atenolol
+
Chlorthalidone
Tradename
Company
Number
Date
Products
TENORETIC 100Almatica PharmaN-018760 RX1984-06-08
1 products, RLD, RS
TENORETIC 50Almatica PharmaN-018760 RX1984-06-08
1 products, RLD
Azilsartan kamedoxomil
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Chlorthalidone
Tradename
Company
Number
Date
Products
EDARBYCLORAzurityN-202331 RX2011-12-20
2 products, RLD, RS
Betaxolol hydrochloride
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Chlorthalidone
Tradename
Company
Number
Date
Products
KERLEDEXSanofiN-019807 DISCN1992-10-30
2 products
Hide discontinued
Chlorthalidone
Tradename
Company
Number
Date
Products
THALITONECasper PharmaN-019574 RX1988-12-20
2 products, RLD
Show 1 discontinued
Chlorthalidone
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Clonidine hydrochloride
Tradename
Company
Number
Date
Products
COMBIPRESBoehringer IngelheimN-017503 DISCN1982-01-01
3 products, RLD
Hide discontinued
Chlorthalidone
+
Metoprolol tartrate
Tradename
Company
Number
Date
Products
LOPRESSIDONENovartisN-019451 DISCN1987-12-31
2 products
Hide discontinued
Chlorthalidone
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Reserpine
Tradename
Company
Number
Date
Products
REGROTONSanofiN-015103 DISCN1982-01-01
1 products
DEMI-REGROTONSanofiN-015103 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
atenolol and chlorthalidoneANDA2024-01-16
chlorthalidoneANDA2024-01-18
edarbyclorNew Drug Application2024-02-01
tenoreticNew Drug Application2023-08-31
thalitoneNew Drug Application2019-12-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
edema—D004487R60.9
glomerulonephritis—D005921N05
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
liver cirrhosisEFO_0001422D008103K74.0
nephrotic syndromeEFO_0004255D009404N04
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Azilsartan Kamedoxomil / Chlorthalidone, Edarbyclor, Azurity
93872492031-07-01U-3
91692382030-02-04DP
90669362028-03-26DP
71575842025-05-22DP
75729202025-01-07DPU-3
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03B: Low-ceiling diuretics, excl. thiazides
— C03BA: Sulfonamides, low-ceiling diuretics, plain
— C03BA04: Chlortalidone
— C03BB: Sulfonamides and potassium in combination, low-ceiling diruetics, excluding thiazides
— C03BB04: Chlortalidone and potassium
— C03E: Diuretics and potassium-sparing agents in combination
— C03EA: Low-ceiling diuretics and potassium-sparing agents
— C03EA06: Chlortalidone and potassium-sparing agents
HCPCS
No data
Clinical
Clinical Trials
104 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I107625151265
Essential hypertensionD000075222—I10——52310
Chronic renal insufficiencyD051436—N18—2—417
Heart failureD006333HP_0001635I50—122—4
Covid-19D000086382—U07.1———112
Left ventricular hypertrophyD017379EFO_0003896————2—2
Cardio-renal syndromeD059347———1—1—2
Aortic valve stenosisD001024HP_0001650————1—1
Aortic valve insufficiencyD001022EFO_0007148————1—1
Metabolic syndromeD024821EFO_0000195E88.810———1—1
Show 2 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cardiovascular diseasesD002318HP_0001626——28—111
Heart diseasesD006331EFO_0003777I51.9—25—18
Coronary diseaseD003327————2—24
Healthy volunteers/patients———2—1——3
Vascular diseasesD014652EFO_0004264I77—21——3
HypercholesterolemiaD006937HP_0003124———2——2
Diabetes mellitusD003920HP_0000819E08-E13——2——2
Myocardial infarctionD009203EFO_0000612I21——1—12
Type 2 diabetes mellitusD003924EFO_0001360E11——1——1
AtherosclerosisD050197EFO_0003914I25.1——1——1
Show 9 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E10—1———1
HypercalciuriaD053565HP_0002150R82.994—1———1
Renal insufficiencyD051437HP_0000083N19—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ambulatory blood pressure monitoringD018660——————11
Vascular stiffnessD059289——————11
StrokeD020521EFO_0000712I63.9————11
Kidney calculiD007669EFO_0004253N20————11
Breast feedingD001942——————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameChlorthalidone
INNchlortalidone
Description
Chlorthalidone is a sulfonamide, a member of isoindoles and a member of monochlorobenzenes.
Classification
Small molecule
Drug classThiazide-like diuretic
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)c1cc(C2(O)NC(=O)c3ccccc32)ccc1Cl
Identifiers
PDB—
CAS-ID77-36-1
RxCUI—
ChEMBL IDCHEMBL1055
ChEBI ID3654
PubChem CID2732
DrugBankDB00310
UNII IDQ0MQD1073Q (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
CA2
CA2
Organism
Homo sapiens
Gene name
CA2
Gene synonyms
NCBI Gene ID
760
Protein name
carbonic anhydrase 2
Protein synonyms
CA-II, CAC, Carbonate dehydratase II, carbonic anhydrase B, Carbonic anhydrase C, Carbonic anhydrase II, carbonic dehydratase, Cyanamide hydratase CA2, epididymis luminal protein 76, epididymis secretory protein Li 282
Uniprot ID
Q96ET9
Mouse ortholog
Car2 (12349)
carbonic anhydrase 2 (Q9DCY9)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Chlorthalidone
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Atenolol
Total medical expenditures per year (USD, in millions)
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Chlorthalidone
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Azilsartan
Total medical expenditures per year (USD, in millions)
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Chlorthalidone
Total medical expenditures per year (USD, in millions)
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Chlorthalidone
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Clonidine
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 3,669 documents
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Safety
Black-box Warning
Black-box warning for: Edarbyclor
Adverse Events
Top Adverse Reactions
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2,553 adverse events reported
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