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Drug ReportsChlorpromazine
Chlorpromazine
Chlorpromazine, Thorazine (chlorpromazine) is a small molecule pharmaceutical. Chlorpromazine was first approved as Thorazine on 1982-01-01. It is used to treat acute intermittent porphyria, anxiety disorders, attention deficit and disruptive behavior disorders, child behavior disorders, and hiccup amongst others in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 2A. In addition, it is known to target alpha-2B adrenergic receptor, D(3) dopamine receptor, short transient receptor potential channel 5, D(4) dopamine receptor, D(1A) dopamine receptor, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2C, histamine H1 receptor, alpha-2C adrenergic receptor, D(2) dopamine receptor, 5-hydroxytryptamine receptor 7, alpha-2A adrenergic receptor, and 5-hydroxytryptamine receptor 6.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
Chlorpromazine (discontinued: Chlorpromazine, Promapar, Sonazine, Thorazine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpromazine hydrochloride
Tradename
Company
Number
Date
Products
THORAZINEGSKN-009149 DISCN1982-01-01
9 products, RLD
THORAZINEGSKN-011120 DISCN1982-01-01
5 products
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Chlorpromazine
Tradename
Company
Number
Date
Products
THORAZINEGSKN-009149 DISCN1982-01-01
2 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
aunt bees five flavorsOTC monograph final2015-03-12
bluzen - winter pine, wintermint, peppermint - kitOTC monograph not final2020-09-11
bluzen hand sanitizer wintermintOTC monograph not final2020-09-10
chlorpromazineANDA2024-04-24
chlorpromazine hciANDA2025-01-08
chlorpromazine hydrochlorideANDA2025-10-01
giant eagle wintermint with fluorideOTC monograph final2019-10-22
giant eagle wintermint zero alcoholOTC monograph final2019-10-22
hey humans whitening wintermint chillOTC monograph final2021-03-01
level wintermint five whitening formula anticavityOTC monograph final2011-05-09
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
vomiting—D014839R11.1
nausea—D009325R11.0
hiccup—D006606R06.6
acute intermittent porphyria—D017118—
tetanusEFO_0005593D013742A35
schizophreniaEFO_0000692D012559F20
psychotic disorders—D011618F20.81
anxiety disordersEFO_0006788D001008F41.1
attention deficit and disruptive behavior disorders—D019958F91.3
child behavior disorders—D002653—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AA: Phenothiazines with aliphatic side-chain, antipsychotics
— N05AA01: Chlorpromazine
HCPCS
Code
Description
J3230
Injection, chlorpromazine hcl, up to 50 mg
Q0161
Chlorpromazine hydrochloride, 5 mg, oral, fda approved prescription anti-emetic, for use as a complete therapeutic substitute for an iv anti-emetic at the time of chemotherapy treatment, not to exceed a 48 hour dosage regimen
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F201114512
Psychotic disordersD011618—F20.81——1214
Bipolar disorderD001714EFO_0000289F30.9———112
Psychomotor agitationD011595——1——1—2
AggressionD000374EFO_0003015————1—1
Psychiatric emergency servicesD004637—————1—1
ManiaD000087122—F30———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
VomitingD014839—R11.11—1——2
RecurrenceD012008———11—12
DeliriumD003693—R41.0—22——2
Covid-19D000086382—U07.1—12——2
Mental disordersD001523EFO_0000677F91.9——1——1
Opioid-related disordersD009293EFO_0005611F11——1——1
Neonatal abstinence syndromeD009357EFO_0005799P96.1——1——1
NeoplasmsD009369—C80—11——1
Neoplasm metastasisD009362EFO_0009708——11——1
Epileptic syndromesD000073376———11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlioblastomaD005909EFO_0000515—11———2
Colonic neoplasmsD003110—C1811———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute intermittent porphyriaD017118——1————1
Oral manifestationsD009912——1————1
TetanusD013742EFO_0005593A351————1
Ischemic strokeD000083242——1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
StrokeD020521EFO_0000712I63.9————11
Type 2 diabetes mellitusD003924EFO_0001360E11————11
EmergenciesD004630——————11
Gastroesophageal refluxD005764EFO_0003948K21————11
PainD010146EFO_0003843R52————11
GlaucomaD005901EFO_0000516H40————11
BehaviorD001519GO_0007610STY/T053————11
Social skillsD066107——————11
Spinal cord injuriesD013119EFO_1001919—————11
Muscle spasticityD009128——————11
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameChlorpromazine
INNchlorpromazine
Description
Chlorpromazine is a substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety. It has a role as a phenothiazine antipsychotic drug, an antiemetic, a dopaminergic antagonist, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an anticoronaviral agent. It is a member of phenothiazines, an organochlorine compound and a tertiary amine.
Classification
Small molecule
Drug classTypical antipsychotic
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc21
Identifiers
PDB—
CAS-ID50-53-3
RxCUI—
ChEMBL IDCHEMBL71
ChEBI ID3647
PubChem CID2726
DrugBankDB00477
UNII IDU42B7VYA4P (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Chlorpromazine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 36,039 documents
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Safety
Black-box Warning
Black-box warning for: Chlorpromazine, Chlorpromazine hci, Chlorpromazine hydrochloride
Adverse Events
Top Adverse Reactions
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5,892 adverse events reported
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