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Drug ReportsChlorpheniramine
Chlorpheniramine
Advil, Capsule, Chlor-trimeton, Chlorpheniramine, Chlorpheniramine / /, Codimal-l.a, Isoclor, Triaminic, Tuxarin, Vituz (chlorpheniramine) is a small molecule pharmaceutical. Chlorpheniramine was first approved as Chlor-trimeton on 1982-01-01. It is used to treat allergic rhinitis perennial and urticaria in the USA. The pharmaceutical is active against histamine H1 receptor.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
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FDA approval date
EMA approval date
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Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Combinations
Advil, Hydrocodone bitartrate, chlorpheniramine pseudoephedrine, Hydrocodone polistirex chlorpheniramine polistirex, Tuxarin (discontinued: Chlor-trimeton, Codeprex, Codimal-l.a., Hydrocodone bitartrate, chlorpheniramine pseudoephedrine, Hydrocodone chlorpheniramine, Hydrocodone polistirex chlorpheniramne polistirex, Isoclor, Penntuss, Pseudoephedrine chlorpheniramine, Triaminic, Tussionex pennkinetic, Tuzistra, Vituz, Zutripro)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpheniramine maleate
+
Ibuprofen
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ADVIL ALLERGY SINUSGSKN-021441 OTC2002-12-19
1 products, RLD, RS
CHILDREN'S ADVIL ALLERGY SINUSGSKN-021587 OTC2004-02-24
1 products, RLD, RS
Chlorpheniramine maleate
+
Ibuprofen
+
Phenylephrine hydrochloride
Tradename
Company
Number
Date
Products
ADVIL ALLERGY AND CONGESTION RELIEFGSKN-022113 OTC2011-12-21
1 products, RLD, RS
ADVIL MULTI-SYMPTOM COLD & FLUGSKN-022113 OTC2017-04-28
1 products, RLD, RS
Chlorpheniramine maleate
Tradename
Company
Number
Date
Products
EFIDAC 24 CHLORPHENIRAMINE MALEATEAlzaN-019746 DISCN1994-11-18
1 products
CHLOR-TRIMETONBayerN-007638 DISCN1982-01-01
2 products, RLD
TELDRINGSKN-017369 DISCN1982-01-01
2 products
CHLOR-TRIMETONMerck & CoN-006921 DISCN1982-01-01
2 products
CHLOR-TRIMETONMerck & CoN-008794 DISCN1982-01-01
1 products
CHLOR-TRIMETONMerck & CoN-008826 DISCN1982-01-01
1 products
Hide discontinued
Chlorpheniramine maleate
+
Phenylpropanolamine hydrochloride
Tradename
Company
Number
Date
Products
TRIAMINIC-12NovartisN-018115 DISCN1982-01-01
1 products
Hide discontinued
Chlorpheniramine maleate
+
Pseudoephedrine sulfate
Tradename
Company
Number
Date
Products
CHLOR-TRIMETONBayerN-018397 DISCN1982-01-01
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATECentral PharmaceuticalsN-019428 DISCN1988-08-02
1 products
ISOCLORFisonsN-018747 DISCN1986-03-06
1 products
CODIMAL-L.A. 12Schwarz PharmaN-018935 DISCN1985-04-15
1 products
Hide discontinued
Chlorpheniramine maleate
+
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
VITUZPersion PharmaceuticalsN-204307 DISCN2013-02-20
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Hydrocodone bitartrate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ZUTRIPROPersion PharmaceuticalsN-022439 DISCN2011-06-08
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Codeine phosphate
Tradename
Company
Number
Date
Products
TUXARIN ERMainPointe PharmaceuticalsN-206323 RX2015-06-22
1 products
Chlorpheniramine polistirex
+
Codeine polistirex
Tradename
Company
Number
Date
Products
PENNTUSSFisonsN-018928 DISCN1985-08-14
1 products
CODEPREXLannettN-021369 DISCN2004-06-21
1 products
TUZISTRA XRTris PharmaN-207768 DISCN2015-04-30
1 products, RLD
Hide discontinued
Chlorpheniramine polistirex
+
Hydrocodone polistirex
Tradename
Company
Number
Date
Products
TUSSIONEX PENNKINETICUCBN-019111 DISCN1987-12-31
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
999 cold remedyOTC monograph not final2013-09-17
999 cold remedy granularOTC monograph not final2013-09-24
999 ganmaolingOTC monograph final2012-07-03
acetaminophen, ascorbic acid, chlorpheniramine maleateExport only2024-05-08
acetaminophen, chlorpheniramine maleate, dextromethorphan hbrC2002632025-09-04
acetaminophen, chlorpheniramine maleate, phenylephrine hclC2002632024-12-03
acetaminophen, dextromethorphan hbr, chlorpheniramine maleateC2002632024-04-03
acetaminophen, phenylephrine hydrochloride, chlorpheniramine maleateExport only2022-11-29
actidom daC2002632024-07-15
adult flu and cough sanafluOTC monograph final2016-12-15
Show 247 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
urticariaEFO_0005531D014581L50
postoperative pain—D010149G89.18
sinusitisEFO_0007486D012852J32
asthmaEFO_0000270D001249J45
obstructive lung diseases—D008173—
cough—D003371R05
common coldEFO_0007214D003139J00
juvenile arthritisEFO_1002007D001171M08
menorrhagiaEFO_0003945D008595N92.0
Show 21 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Chlorpheniramine Maleate / Codeine Phosphate, Tuxarin Er, Mainpointe
90669422032-01-03U-1716
91079212032-01-03DP
Chlorpheniramine Maleate / Ibuprofen / Pseudoephedrine Hydrochloride, Advil Allergy Sinus, Haleon Us Holdings
78632872027-02-28DP
Chlorpheniramine Maleate / Ibuprofen / Pseudoephedrine Hydrochloride, Children'S Advil Allergy Sinus, Haleon Us Holdings
102386402024-05-25DP
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AB: Substituted alkylamines, systemic antihistamines
— R06AB04: Chlorphenamine
— R06AB54: Chlorphenamine, combinations
HCPCS
No data
Clinical
Clinical Trials
218 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544——4913934
Healthy volunteers/patients———18——1—19
CoughD003371—R052345519
Helicobacter infectionsD016481EFO_1000961——354415
Respiratory tract infectionsD012141—J06.9—335111
Communicable diseasesD003141———182111
Common coldD003139EFO_0007214J00—163—10
Type 2 diabetes mellitusD003924EFO_0001360E11—21215
BronchitisD001991—J40——1225
Diabetes mellitusD003920EFO_0000400E08-E13—113—4
Show 37 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382—U07.1—53—16
Allergic rhinitisD065631—J30.9222——5
RhinitisD012220EFO_0008521J31221——5
Allergic rhinitis seasonalD006255EFO_0003956J30211——4
PainD010146EFO_0003843R52——2—24
Esophageal neoplasmsD004938—C15—21——3
Human influenzaD007251EFO_0007328J11.1——3——3
Ulcerative colitisD003093EFO_0000729K51——3——3
ColitisD003092EFO_0003872K52.9——3——3
UlcerD014456MPATH_579———3——3
Show 22 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatitis bD006509——15———6
Chronic hepatitis bD019694EFO_0004239B18.115———6
HepatitisD006505—K75.915———6
Hepatitis aD006506EFO_0007305B1515———6
SyndromeD013577———1——34
NeoplasmsD009369—C8031———3
InflammationD007249MP_0001845——1——12
LeukemiaD007938—C95—2———2
Myelodysplastic syndromesD009190—D46—2———2
Myeloid leukemia acuteD015470—C92.0—2———2
Show 82 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypersensitivityD006967EFO_0003785T78.401———12
Therapeutic equivalencyD013810——1————1
Non-small-cell lung carcinomaD002289——1————1
GlioblastomaD005909EFO_0000515—1————1
FrailtyD000073496—R53.11————1
AgingD000375GO_0007568R41.811————1
Mucociliary clearanceD009079——1————1
High-intensity focused ultrasound ablationD057086——1————1
Voice disordersD014832——1————1
Duchenne muscular dystrophyD020388EFO_0000429—1————1
Show 2 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Whooping coughD014917EFO_0000650A37————22
Chronic coughD000096822—R05.3————22
Irritable bowel syndromeD043183EFO_0000555K58————22
DiarrheaD003967—R19.7————22
ObesityD009765EFO_0001073E66.9————22
SchizophreniaD012559EFO_0000692F20————11
Psychotic disordersD011618—F20.81————11
Chronic urticariaD000080223—L50.8————11
EmergenciesD004630——————11
UrticariaD014581EFO_0005531L50————11
Show 43 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameChlorpheniramine
INNchlorphenamine
Description
Chlorphenamine is a tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. It has a role as a H1-receptor antagonist, an antipruritic drug, a histamine antagonist, a serotonin uptake inhibitor, an antidepressant and an anti-allergic agent. It is a tertiary amino compound, a member of monochlorobenzenes and a member of pyridines.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Identifiers
PDB—
CAS-ID132-22-9
RxCUI—
ChEMBL IDCHEMBL505
ChEBI ID52010
PubChem CID2725
DrugBankDB01114
UNII ID3U6IO1965U (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
3269
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Q6P9E5
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
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Estimated US medical usage
Chlorpheniramine
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Acetaminophen
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Phenylephrine
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Chlorpheniramine
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Pentoxyverine
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Chlorpheniramine
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Chlorpheniramine
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Phenylephrine
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Codeine
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Chlorpheniramine
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Dextromethorphan
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Chlorpheniramine
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Phenylephrine
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Dihydrocodeine
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Chlorpheniramine
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Epinephrine
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Chlorpheniramine
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Phenylephrine
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Guaifenesin
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Chlorpheniramine
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Hydrocodone
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Chlorpheniramine
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Hydrocodone
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Chlorpheniramine
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Methscopolamine
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Chlorpheniramine
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Phenylephrine
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Chlorpheniramine
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Phenylephrine
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Pyrilamine
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Chlorpheniramine
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Phenylpropanolamine
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Chlorpheniramine
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Pseudoephedrine
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 5,221 documents
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Safety
Black-box Warning
Black-box warning for: Codeine and chlorpheniramine maleate er, Hydrocodone polistirex and chlorpheniramine polistirex, Tuxarin
Adverse Events
Top Adverse Reactions
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9,247 adverse events reported
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