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Drug ReportsChlorpheniramine
Chlorpheniramine
Advil, Capsule, Chlor-trimeton, Chlorpheniramine, Chlorpheniramine / /, Codimal-l.a, Isoclor, Triaminic, Tuxarin, Vituz (chlorpheniramine) is a small molecule pharmaceutical. Chlorpheniramine was first approved as Chlor-trimeton on 1982-01-01. It is used to treat allergic rhinitis perennial and urticaria in the USA. The pharmaceutical is active against histamine H1 receptor.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
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FDA approval date
EMA approval date
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Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Combinations
Advil, Hydrocodone bitartrate, chlorpheniramine pseudoephedrine, Hydrocodone polistirex chlorpheniramine polistirex, Tuxarin (discontinued: Chlor-trimeton, Codeprex, Codimal-l.a., Hydrocodone bitartrate, chlorpheniramine pseudoephedrine, Hydrocodone chlorpheniramine, Hydrocodone polistirex chlorpheniramne polistirex, Isoclor, Penntuss, Pseudoephedrine chlorpheniramine, Triaminic, Tussionex pennkinetic, Tuzistra, Vituz, Zutripro)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpheniramine maleate
+
Ibuprofen
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ADVIL ALLERGY SINUSGSKN-021441 OTC2002-12-19
1 products, RLD, RS
CHILDREN'S ADVIL ALLERGY SINUSGSKN-021587 OTC2004-02-24
1 products, RLD, RS
Chlorpheniramine maleate
+
Ibuprofen
+
Phenylephrine hydrochloride
Tradename
Company
Number
Date
Products
ADVIL ALLERGY AND CONGESTION RELIEFGSKN-022113 OTC2011-12-21
1 products, RLD, RS
ADVIL MULTI-SYMPTOM COLD & FLUGSKN-022113 OTC2017-04-28
1 products, RLD, RS
Chlorpheniramine maleate
Tradename
Company
Number
Date
Products
EFIDAC 24 CHLORPHENIRAMINE MALEATEAlzaN-019746 DISCN1994-11-18
1 products
CHLOR-TRIMETONBayerN-007638 DISCN1982-01-01
2 products, RLD
TELDRINGSKN-017369 DISCN1982-01-01
2 products
CHLOR-TRIMETONMerck & CoN-006921 DISCN1982-01-01
2 products
CHLOR-TRIMETONMerck & CoN-008794 DISCN1982-01-01
1 products
CHLOR-TRIMETONMerck & CoN-008826 DISCN1982-01-01
1 products
Hide discontinued
Chlorpheniramine maleate
+
Phenylpropanolamine hydrochloride
Tradename
Company
Number
Date
Products
TRIAMINIC-12NovartisN-018115 DISCN1982-01-01
1 products
Hide discontinued
Chlorpheniramine maleate
+
Pseudoephedrine sulfate
Tradename
Company
Number
Date
Products
CHLOR-TRIMETONBayerN-018397 DISCN1982-01-01
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATECentral PharmaceuticalsN-019428 DISCN1988-08-02
1 products
ISOCLORFisonsN-018747 DISCN1986-03-06
1 products
CODIMAL-L.A. 12Schwarz PharmaN-018935 DISCN1985-04-15
1 products
Hide discontinued
Chlorpheniramine maleate
+
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
VITUZPersion PharmaceuticalsN-204307 DISCN2013-02-20
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Hydrocodone bitartrate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ZUTRIPROPersion PharmaceuticalsN-022439 DISCN2011-06-08
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Codeine phosphate
Tradename
Company
Number
Date
Products
TUXARIN ERMainPointe PharmaceuticalsN-206323 RX2015-06-22
1 products
Chlorpheniramine polistirex
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Codeine polistirex
Tradename
Company
Number
Date
Products
PENNTUSSFisonsN-018928 DISCN1985-08-14
1 products
CODEPREXLannettN-021369 DISCN2004-06-21
1 products
TUZISTRA XRTris PharmaN-207768 DISCN2015-04-30
1 products, RLD
Hide discontinued
Chlorpheniramine polistirex
+
Hydrocodone polistirex
Tradename
Company
Number
Date
Products
TUSSIONEX PENNKINETICUCBN-019111 DISCN1987-12-31
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
999 cold remedyOTC monograph not final2013-09-17
999 cold remedy granularOTC monograph not final2013-09-24
999 ganmaolingOTC monograph final2012-07-03
acetaminophen, ascorbic acid, chlorpheniramine maleateExport only2020-04-02
acetaminophen, chlorpheniramine maleate, phenylephrine hclOTC monograph final2023-09-04
acetaminophen, dextromethorphan hbr, chlorpheniramine maleateC2002632024-04-03
acetaminophen, phenylephrine hydrochloride, chlorpheniramine maleateExport only2022-11-29
actidom daC2002632024-07-15
adult flu and cough sanafluOTC monograph final2016-12-15
advil allergy and congestion reliefNew Drug Application2024-06-20
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
urticariaEFO_0005531D014581L50
postoperative pain—D010149G89.18
sinusitisEFO_0007486D012852J32
asthmaEFO_0000270D001249J45
obstructive lung diseasesHP_0006536D008173—
coughHP_0012735D003371R05
common coldEFO_0007214D003139J00
juvenile arthritisEFO_1002007D001171M08
menorrhagiaEFO_0003945D008595N92.0
Show 21 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Chlorpheniramine Maleate / Codeine Phosphate, Tuxarin Er, Mainpointe
90669422032-01-03U-1716
91079212032-01-03DP
Chlorpheniramine Maleate / Ibuprofen / Pseudoephedrine Hydrochloride, Advil Allergy Sinus, Haleon Us Holdings
78632872027-02-28DP
Chlorpheniramine Maleate / Ibuprofen / Pseudoephedrine Hydrochloride, Children'S Advil Allergy Sinus, Haleon Us Holdings
102386402024-05-25DP
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AB: Substituted alkylamines, systemic antihistamines
— R06AB04: Chlorphenamine
— R06AB54: Chlorphenamine, combinations
HCPCS
No data
Clinical
Clinical Trials
770 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52162017131577
Postoperative painD010149—G89.185611331266
Healthy volunteers/patients———511—2660
Opioid-related disordersD009293EFO_0005611F1110121391657
InfectionsD007239EFO_0000544—369131039
SyndromeD013577———773825
Chronic painD059350HP_0012532—3388425
CoughD003371HP_0012735R055384323
NeoplasmsD009369—C809542422
Acute painD059787—R525461319
Show 153 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Cocaine-related disordersD019970—F14432——8
RhinitisD012220EFO_0008521J31243——8
LymphomaD008223—C85.9232—17
Covid-19D000086382———53—27
Multiple myelomaD009101—C90.0122—16
SclerosisD012598———42——5
Treatment-resistant depressive disorderD061218——131——5
Neoplasm metastasisD009362EFO_0009708—222——5
Psychomotor agitationD011595———21—25
LeukemiaD007938—C95131—15
Show 74 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatitis bD006509——15———6
Chronic hepatitis bD019694EFO_0004239B18.115———6
HyperalgesiaD006930——12——25
Prostatic neoplasmsD011471—C6132———4
Non-hodgkin lymphomaD008228—C85.923———4
DiarrheaD003967HP_0002014R19.7—1——34
Motor neuron diseaseD016472EFO_0003782G12.213———3
Breast neoplasmsD001943EFO_0003869C5011——23
FibromyalgiaD005356EFO_0005687M79.121———3
Spinal cord injuriesD013119EFO_1001919——2——13
Show 113 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug interactionsD004347——6———39
TuberculosisD014376EFO_0000774A15-A191———12
Food-drug interactionsD018565——2————2
Voice disordersD014832——2————2
HypersensitivityD006967HP_0012393T78.401———12
Squamous cell carcinoma of head and neckD000077195——1———12
Renal insufficiencyD051437HP_0000083N192————2
Liver diseasesD008107HP_0002910K70-K772————2
Hepatic insufficiencyD048550——2————2
MelanomaD008545——1————1
Show 30 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ApneaD001049HP_0002104R06.81————22
PneumoniaD011014EFO_0003106—————22
Emergence deliriumD000071257——————22
Whooping coughD014917EFO_0000650A37.0————22
Pregnancy rateD018873——————22
ObesityD009765EFO_0001073E66.9————22
Torsades de pointesD016171EFO_0005307I47.21————11
Cardiovascular diseasesD002318HP_0001626—————11
Post-traumatic stress disordersD013313EFO_0001358F43.1————11
Traumatic stress disordersD040921——————11
Show 57 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameChlorpheniramine
INNchlorphenamine
Description
Chlorphenamine is a tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. It has a role as a H1-receptor antagonist, an antipruritic drug, a histamine antagonist, a serotonin uptake inhibitor, an antidepressant and an anti-allergic agent. It is a tertiary amino compound, a member of monochlorobenzenes and a member of pyridines.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Identifiers
PDB—
CAS-ID132-22-9
RxCUI—
ChEMBL IDCHEMBL505
ChEBI ID52010
PubChem CID2725
DrugBankDB01114
UNII ID3U6IO1965U (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
3269
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Q6P9E5
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Chlorpheniramine
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Acetaminophen
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Phenylephrine
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Chlorpheniramine
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Carbetapentane
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Phenylephrine
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Chlorpheniramine
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Chlorpheniramine
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Phenylephrine
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Codeine
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Chlorpheniramine
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Dextromethorphan
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Chlorpheniramine
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Phenylephrine
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Dihydrocodeine
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Chlorpheniramine
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Epinephrine
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Chlorpheniramine
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Phenylephrine
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Guaifenesin
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Chlorpheniramine
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Hydrocodone
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Chlorpheniramine
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Hydrocodone
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Chlorpheniramine
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Methscopolamine
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Chlorpheniramine
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Phenylephrine
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Chlorpheniramine
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Phenylephrine
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Pyrilamine
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Chlorpheniramine
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Phenylpropanolamine
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Chlorpheniramine
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Pseudoephedrine
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Trends
PubMed Central
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Additional graphs summarizing 4,880 documents
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Safety
Black-box Warning
Black-box warning for: Codeine and chlorpheniramine maleate er, Hydrocodone polistirex and chlorpheniramine polistirex, Tuxarin
Adverse Events
Top Adverse Reactions
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8,317 adverse events reported
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