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Drug ReportsChlorpheniramine
Chlorpheniramine
Advil, Capsule, Chlor-trimeton, Chlorpheniramine, Chlorpheniramine / /, Codimal-l.a, Isoclor, Triaminic, Tuxarin, Vituz (chlorpheniramine) is a small molecule pharmaceutical. Chlorpheniramine was first approved as Chlor-trimeton on 1982-01-01. It is used to treat allergic rhinitis perennial and urticaria in the USA. The pharmaceutical is active against histamine H1 receptor.
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Clinical
Drug
Target
Variants
Financial
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Safety
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5D
1M
3M
6M
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1Y
2Y
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FDA approval date
EMA approval date
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Study first post date
Last update post date
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Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
skin and connective tissue diseasesD017437
immune system diseasesD007154
Trade Name
FDA
EMA
Combinations
Advil, Tuxarin (generic drugs available since 2009-05-13, discontinued: Capsule, Chlor-trimeton, Codimal-l.a., Isoclor, Triaminic, Vituz, Zutripro)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorpheniramine maleate
Tradename
Company
Number
Date
Products
EFIDAC 24 CHLORPHENIRAMINE MALEATEAlzaN-019746 DISCN1994-11-18
1 products
CHLOR-TRIMETONBayerN-007638 DISCN1982-01-01
2 products, RLD
TELDRINGSKN-017369 DISCN1982-01-01
2 products
CHLOR-TRIMETONMerck Sharp & DohmeN-006921 DISCN1982-01-01
2 products
CHLOR-TRIMETONMerck Sharp & DohmeN-008794 DISCN1982-01-01
1 products
CHLOR-TRIMETONMerck Sharp & DohmeN-008826 DISCN1982-01-01
1 products
Hide discontinued
Chlorpheniramine maleate
+
Codeine phosphate
Tradename
Company
Number
Date
Products
TUXARIN ERMainPointe PharmaceuticalsN-206323 RX2015-06-22
1 products
Chlorpheniramine maleate
+
Hydrocodone bitartrate
Tradename
Company
Number
Date
Products
VITUZPersion PharmaceuticalsN-204307 DISCN2013-02-20
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Hydrocodone bitartrate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ZUTRIPROPersion PharmaceuticalsN-022439 DISCN2011-06-08
1 products, RLD
Hide discontinued
Chlorpheniramine maleate
+
Ibuprofen
+
Phenylephrine hydrochloride
Tradename
Company
Number
Date
Products
ADVIL MULTI-SYMPTOM COLD & FLUHALEON US HOLDINGSN-022113 OTC2017-04-28
1 products, RLD, RS
ADVIL ALLERGY AND CONGESTION RELIEFHALEON US HOLDINGSN-022113 OTC2011-12-21
1 products, RLD, RS
Chlorpheniramine maleate
+
Ibuprofen
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
ADVIL ALLERGY SINUSHALEON US HOLDINGSN-021441 OTC2002-12-19
1 products, RLD, RS
CHILDREN'S ADVIL ALLERGY SINUSHALEON US HOLDINGSN-021587 OTC2004-02-24
1 products, RLD, RS
Chlorpheniramine maleate
+
Phenylpropanolamine hydrochloride
Tradename
Company
Number
Date
Products
COLD CAPSULE IVGRAHAM DMN-018793 DISCN1985-04-25
1 products
COLD CAPSULE VGRAHAM DMN-018794 DISCN1985-04-23
1 products
TRIAMINIC-12NovartisN-018115 DISCN1982-01-01
1 products
Hide discontinued
Chlorpheniramine maleate
+
Pseudoephedrine hydrochloride
Tradename
Company
Number
Date
Products
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATECentral PharmaceuticalsN-019428 DISCN1988-08-02
1 products
ISOCLORFisonsN-018747 DISCN1986-03-06
1 products
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATEGRAHAM DMN-018843 DISCN1985-03-18
1 products
PSEUDOEPHEDRINE HYDROCHLORIDE AND CHLORPHENIRAMINE MALEATEGRAHAM DMN-018844 DISCN1985-03-20
1 products
CODIMAL-L.A. 12Schwarz PharmaN-018935 DISCN1985-04-15
1 products
Hide discontinued
Chlorpheniramine maleate
+
Pseudoephedrine sulfate
Tradename
Company
Number
Date
Products
CHLOR-TRIMETONBayerN-018397 DISCN1982-01-01
1 products, RLD
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
999 cold remedyOTC monograph not final2013-09-17
999 cold remedy granularOTC monograph not final2013-09-24
999 ganmaolingOTC monograph final2012-07-03
acetaminophen, ascorbic acid, chlorpheniramine maleateExport only2020-04-02
acetaminophen, chlorpheniramine maleate, phenylephrine hclOTC monograph final2023-09-04
acetaminophen, phenylephrine hydrochloride, chlorpheniramine maleateExport only2022-11-29
actidom daOTC monograph final2022-01-20
adult flu and cough sanafluOTC monograph final2016-12-15
advilNew Drug Application2024-01-31
advil allergy and congestion reliefNew Drug Application2024-01-31
Show 281 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
urticariaEFO_0005531D014581L50
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Chlorpheniramine Maleate / Codeine Phosphate, Tuxarin Er, Mainpointe
90669422032-01-03U-1716
91079212032-01-03DP
Chlorpheniramine Maleate / Ibuprofen / Pseudoephedrine Hydrochloride, Advil Allergy Sinus, Haleon Us Holdings
78632872027-02-28DP
Chlorpheniramine Maleate / Ibuprofen / Pseudoephedrine Hydrochloride, Children'S Advil Allergy Sinus, Haleon Us Holdings
102386402024-05-25DP
ATC Codes
R: Respiratory system drugs
— R06: Antihistamines for systemic use
— R06A: Antihistamines for systemic use
— R06AB: Substituted alkylamines, systemic antihistamines
— R06AB04: Chlorphenamine
— R06AB54: Chlorphenamine, combinations
HCPCS
No data
Clinical
Clinical Trials
747 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52162017121576
Healthy volunteers/patients———501—2659
Postoperative painD010149—G89.1843527947
Opioid-related disordersD009293EFO_0005611F119121141346
InfectionsD007239EFO_0000544—3—38721
NeoplasmsD009369—C806441418
Chronic painD059350HP_0012532—1256317
CoughD003371HP_0012735R055172116
Hiv infectionsD015658EFO_0000764B203312312
Substance-related disordersD019966EFO_0003890F133222211
Show 92 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Acute painD059787—R524—2—28
Cocaine-related disordersD019970—F14431——7
Covid-19D000086382—U07.1—53—16
Treatment-resistant depressive disorderD061218——131——5
VomitingD014839HP_0002013R11.11—3—15
NauseaD009325HP_0002018R11.0——3—25
Cancer painD000072716—G89.3——2—24
SchizophreniaD012559EFO_0000692F20221—14
Rett syndromeD015518Orphanet_778F84.2—21—14
Myelodysplastic syndromesD009190—D46—21—14
Show 51 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatitis bD006509——14———5
Prostatic neoplasmsD011471—C6132———4
HyperalgesiaD006930——12——14
Amyotrophic lateral sclerosisD000690HP_0007354G12.2113———3
Breast neoplasmsD001943EFO_0003869C5011——23
FibromyalgiaD005356EFO_0005687M79.121———3
Spinal cord injuriesD013119EFO_1001919——2——13
Parkinson diseaseD010300EFO_0002508G20—2——13
Irritable bowel syndromeD043183EFO_0000555K58—1——23
Central nervous system neoplasmsD016543——22——13
Show 73 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug interactionsD004347——4———26
TuberculosisD014376EFO_0000774A15-A191———12
Food-drug interactionsD018565——2————2
HypersensitivityD006967HP_0012393T78.401———12
Renal insufficiencyD051437HP_0000083N192————2
Hepatic insufficiencyD048550——2————2
MelanomaD008545——1————1
HepacivirusD016174——1————1
Mitochondrial diseasesD028361EFO_0000591—1————1
Therapeutic equivalencyD013810——1————1
Show 17 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Whooping coughD014917EFO_0000650A37————22
ObesityD009765EFO_0001073E66.9————22
Cardiovascular diseasesD002318HP_0001626—————11
HepatitisD006505HP_0012115K75.9————11
Post-traumatic stress disordersD013313EFO_0001358F43.1————11
Psychotic disordersD011618—F20.81————11
Attention deficit disorder with hyperactivityD001289EFO_0003888F90————11
Pituitary dwarfismD004393EFO_1001109E23.0————11
Neurotoxicity syndromesD020258—G92————11
FatigueD005221HP_0012378R53.83————11
Show 41 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameChlorpheniramine
INNchlorphenamine
Description
Chlorphenamine is a tertiary amino compound that is propylamine which is substituted at position 3 by a pyridin-2-yl group and a p-chlorophenyl group and in which the hydrogens attached to the nitrogen are replaced by methyl groups. A histamine H1 antagonist, it is used to relieve the symptoms of hay fever, rhinitis, urticaria, and asthma. It has a role as a H1-receptor antagonist, an antipruritic drug, a histamine antagonist, a serotonin uptake inhibitor, an antidepressant and an anti-allergic agent. It is a tertiary amino compound, a member of monochlorobenzenes and a member of pyridines.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Identifiers
PDB—
CAS-ID132-22-9
RxCUI—
ChEMBL IDCHEMBL505
ChEBI ID52010
PubChem CID2725
DrugBankDB01114
UNII ID3U6IO1965U (ChemIDplus, GSRS)
Target
Agency Approved
HRH1
HRH1
Organism
Homo sapiens
Gene name
HRH1
Gene synonyms
NCBI Gene ID
3269
Protein name
histamine H1 receptor
Protein synonyms
histamine receptor, subclass H1
Uniprot ID
Q6P9E5
Mouse ortholog
Hrh1 (15465)
histamine H1 receptor (Q91XN3)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Chlorpheniramine
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Acetaminophen
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Phenylephrine
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Chlorpheniramine
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Carbetapentane
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Chlorpheniramine
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Chlorpheniramine
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Phenylephrine
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Codeine
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Chlorpheniramine
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Dextromethorphan
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Chlorpheniramine
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Phenylephrine
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Dihydrocodeine
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Chlorpheniramine
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Epinephrine
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Chlorpheniramine
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Phenylephrine
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Guaifenesin
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Chlorpheniramine
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Hydrocodone
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Phenylephrine
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Hydrocodone
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Chlorpheniramine
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Methscopolamine
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Chlorpheniramine
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Phenylephrine
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Chlorpheniramine
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Phenylephrine
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Pyrilamine
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Chlorpheniramine
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Phenylpropanolamine
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Chlorpheniramine
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Pseudoephedrine
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Trends
PubMed Central
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Additional graphs summarizing 4,680 documents
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Safety
Black-box Warning
Black-box warning for: Codeine and chlorpheniramine maleate er, Hydrocodone polistirex and chlorpheniramine polistirex, Tuxarin
Adverse Events
Top Adverse Reactions
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36,488 adverse events reported
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