Chlorothiazide
Aldoclor, Chlorothiazide, Diupres, Diuril (chlorothiazide) is a small molecule pharmaceutical. Chlorothiazide was first approved as Diuril on 1982-01-01. It is used to treat edema, glomerulonephritis, heart failure, hypertension, and liver cirrhosis amongst others in the USA. The pharmaceutical is active against solute carrier family 12 member 3.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Diuril (generic drugs available since 2009-10-16, discontinued: Diuril)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlorothiazide
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DIURIL | Salix Pharmaceuticals | N-011870 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Chlorothiazide
+
Methyldopa
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ALDOCLOR-150 | Merck KGaA | N-016016 DISCN | 1982-01-01 | 1 products |
| ALDOCLOR-250 | Merck KGaA | N-016016 DISCN | 1982-01-01 | 1 products |
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Chlorothiazide
+
Reserpine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DIUPRES-250 | Merck KGaA | N-011635 DISCN | 1987-08-26 | 1 products |
| DIUPRES-500 | Merck KGaA | N-011635 DISCN | 1987-08-26 | 1 products |
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Chlorothiazide sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DIURIL | Rising Pharmaceuticals | N-011145 DISCN | 1982-01-01 | 1 products, RLD |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| chlorothiazide | ANDA | 2023-12-01 |
| chlorothiazide sodium | NDA authorized generic | 2022-08-29 |
| diuril | New Drug Application | 2021-11-01 |
| sodium diuril | New Drug Application | 2022-07-01 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03A: Low-ceiling diuretics, thiazides
— C03AA: Thiazides, plain
— C03AA04: Chlorothiazide
— C03AB: Thiazides and potassium in combination
— C03AB04: Chlorothiazide and potassium
— C03AH: Thiazides, combinations with psycholeptics and/or analgesics
— C03AH01: Chlorothiazide, combinations
HCPCS
Code | Description |
|---|---|
| J1205 | Injection, chlorothiazide sodium, per 500 mg |
Clinical
Clinical Trials
12 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | 1 | 1 | 2 | 4 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | 3 | — | 4 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | 1 | 1 | 2 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 1 | 1 | — | 2 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | 1 | — | 1 |
| Acute liver failure | D017114 | HP_0004448 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bronchopulmonary dysplasia | D001997 | — | P27.8 | — | 1 | 1 | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nephrogenic diabetes insipidus | D018500 | — | N25.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Chlorothiazide |
| INN | chlorothiazide |
| Description | Chlorothiazide is 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension. It has a role as a diuretic and an antihypertensive agent. |
| Classification | Small molecule |
| Drug class | diuretics (thiazide derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)c1cc2c(cc1Cl)N=CNS2(=O)=O |
Identifiers
| PDB | — |
| CAS-ID | 58-94-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL842 |
| ChEBI ID | 3640 |
| PubChem CID | 2720 |
| DrugBank | DB00880 |
| UNII ID | 77W477J15H (ChemIDplus, GSRS) |
Target
Agency Approved
SLC12A3
SLC12A3
Organism
Homo sapiens
Gene name
SLC12A3
Gene synonyms
NCC, TSC
NCBI Gene ID
Protein name
solute carrier family 12 member 3
Protein synonyms
Na-Cl cotransporter, Na-Cl symporter, NaCl electroneutral thiazide-sensitive cotransporter, NCC, sodium-chloride co-transporter, solute carrier family 12 (sodium/chloride transporter), member 3, thiazide-sensitive Na-Cl cotransporter, Thiazide-sensitive sodium-chloride cotransporter
Uniprot ID
Mouse ortholog
Slc12a3 (20497)
solute carrier family 12 member 3 (P59158)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Chlorothiazide
Total medical expenditures per year (USD, in millions)
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Chlorothiazide
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Methyldopa
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,353 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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50,912 adverse events reported
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