Chloroquine
Aralen, Chloroquine (chloroquine) is a small molecule pharmaceutical. Chloroquine was first approved as Aralen hydrochloride on 1982-01-01. It is used to treat amebiasis, avian malaria, discoid lupus erythematosus, falciparum malaria, and malaria amongst others in the USA. It is known to target mas-related G-protein coupled receptor member X1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Chloroquine (discontinued: Aralen, Chloroquine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chloroquine phosphate
Chloroquine hydrochloride
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| chloroquine phosphate | ANDA | 2026-01-13 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0390 | Injection, chloroquine hydrochloride, up to 250 mg |
Clinical
Clinical Trials
669 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | 10 | 79 | 90 | 24 | 29 | 204 |
| Malaria | D008288 | EFO_0001068 | B54 | 18 | 23 | 33 | 27 | 28 | 118 |
| Vivax malaria | D016780 | EFO_0007445 | B51 | 1 | 9 | 15 | 16 | 10 | 49 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | 2 | 15 | 22 | 5 | 9 | 46 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | 6 | 10 | 12 | 10 | 10 | 42 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 3 | 16 | 12 | 8 | 38 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | 4 | 13 | 11 | 8 | 35 |
| Infections | D007239 | EFO_0000544 | — | 2 | 11 | 14 | 1 | 4 | 29 |
| Syndrome | D013577 | — | — | 3 | 13 | 6 | 2 | 4 | 24 |
| Sars-cov-2 | D000086402 | — | — | — | 13 | 10 | 2 | 1 | 23 |
Show 79 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | 1 | 6 | 11 | — | 1 | 16 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 6 | 11 | 1 | — | — | 14 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | 5 | 7 | — | 2 | 13 |
| Communicable diseases | D003141 | — | — | 1 | 7 | 6 | — | — | 13 |
| Coronavirus | D017934 | — | — | — | 3 | 7 | — | 2 | 12 |
| Glioblastoma | D005909 | EFO_0000515 | — | 4 | 4 | 1 | — | — | 7 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 5 | — | 1 | 6 |
| Acute lung injury | D055371 | EFO_0004610 | — | 1 | 3 | 4 | — | — | 6 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | 1 | 3 | 4 | — | — | 6 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 4 | 1 | — | 1 | 6 |
Show 38 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 12 | 7 | — | — | — | 18 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 8 | 11 | — | — | — | 17 |
| Lung neoplasms | D008175 | — | C34.90 | 6 | 8 | — | — | — | 11 |
| Prostatic neoplasms | D011471 | — | C61 | 5 | 6 | — | — | — | 9 |
| Melanoma | D008545 | — | — | 7 | 3 | — | — | 1 | 8 |
| Adenocarcinoma | D000230 | — | — | 5 | 6 | — | — | 1 | 8 |
| Non-small-cell lung carcinoma | D002289 | — | — | 4 | 6 | — | — | — | 7 |
| Colorectal neoplasms | D015179 | — | — | 2 | 5 | — | — | — | 7 |
| Carcinoma | D002277 | — | C80.0 | 5 | 4 | — | — | — | 6 |
| Multiple myeloma | D009101 | — | C90.0 | 4 | 1 | — | — | — | 5 |
Show 90 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | 1 | 2 |
| Immunosuppression therapy | D007165 | — | — | 1 | — | — | — | 1 | 2 |
| Fibrosis | D005355 | — | — | 2 | — | — | — | — | 2 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | — | — | — | 1 | 2 |
| Rosacea | D012393 | — | L71 | 1 | — | — | — | 1 | 2 |
| Plasmacytoma | D010954 | — | C90.3 | 1 | — | — | — | — | 1 |
| Gliosarcoma | D018316 | — | — | 1 | — | — | — | — | 1 |
| Headache | D006261 | — | R51 | 1 | — | — | — | — | 1 |
| Neck pain | D019547 | — | M54.2 | 1 | — | — | — | — | 1 |
| Sleep wake disorders | D012893 | — | G47 | 1 | — | — | — | — | 1 |
Show 14 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | — | 3 | 3 |
| Nephritis | D009393 | — | N05 | — | — | — | — | 3 | 3 |
| Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | — | — | — | 2 | 2 |
| Thyroiditis | D013966 | — | E06 | — | — | — | — | 2 | 2 |
| Hashimoto disease | D050031 | EFO_0003779 | E06.3 | — | — | — | — | 2 | 2 |
| Hair diseases | D006201 | — | — | — | — | — | — | 2 | 2 |
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Immunotherapy | D007167 | — | — | — | — | — | — | 1 | 1 |
| Cytokine release syndrome | D000080424 | — | D89.83 | — | — | — | — | 1 | 1 |
| Acute kidney injury | D058186 | — | N17 | — | — | — | — | 1 | 1 |
Show 30 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Chloroquine |
| INN | chloroquine |
| Description | Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. It has a role as an antimalarial, an antirheumatic drug, a dermatologic drug, an autophagy inhibitor and an anticoronaviral agent. It is an aminoquinoline, a secondary amino compound, a tertiary amino compound and an organochlorine compound. It is a conjugate base of a chloroquine(2+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 |
Identifiers
| PDB | — |
| CAS-ID | 54-05-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL76 |
| ChEBI ID | 3638 |
| PubChem CID | 2719 |
| DrugBank | DB00608 |
| UNII ID | 886U3H6UFF (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PSAP
PSAP
Organism
Homo sapiens
Gene name
PSAP
Gene synonyms
GLBA, SAP1
NCBI Gene ID
Protein name
prosaposin
Protein synonyms
precursor of saposins, Proactivator polypeptide, saposin-A, saposin-B, saposin-C, saposin-D, sphingolipid activator protein-1, sphingolipid activator protein-2
Uniprot ID
Mouse ortholog
Psap (19156)
prosaposin (Q61207)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Chloroquine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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72,431 adverse events reported
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