Chloroquine
Aralen, Chloroquine (chloroquine) is a small molecule pharmaceutical. Chloroquine was first approved as Aralen hydrochloride on 1982-01-01. It is used to treat amebiasis, avian malaria, discoid lupus erythematosus, falciparum malaria, and malaria amongst others in the USA. It is known to target mas-related G-protein coupled receptor member X1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Chloroquine (discontinued: Aralen, Chloroquine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chloroquine phosphate
Chloroquine hydrochloride
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| chloroquine phosphate | ANDA | 2024-10-09 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0390 | Injection, chloroquine hydrochloride, up to 250 mg |
Clinical
Clinical Trials
247 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malaria | D008288 | EFO_0001068 | B54 | 18 | 22 | 35 | 31 | 28 | 123 |
| Covid-19 | D000086382 | — | — | 2 | 19 | 18 | 10 | 10 | 51 |
| Vivax malaria | D016780 | EFO_0007445 | B51 | 1 | 8 | 14 | 16 | 10 | 47 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | 5 | 9 | 10 | 10 | 9 | 37 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 5 | 6 | 3 | 5 | 16 |
| Infections | D007239 | EFO_0000544 | — | — | 4 | 3 | 4 | 3 | 13 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 8 | 2 | 1 | 11 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | — | 8 | 2 | 1 | 11 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | — | 3 | 3 | 3 | 9 |
| Recurrence | D012008 | — | — | — | 1 | 1 | 1 | 3 | 5 |
Show 17 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | — | — | 5 | 2 | — | — | 6 |
| Glioblastoma | D005909 | EFO_0000515 | — | 3 | 2 | 1 | — | — | 5 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 3 | 1 | — | 1 | 4 |
| Coronavirus | D017934 | — | — | — | — | 1 | — | 2 | 3 |
| Hiv | D006678 | — | — | — | — | 1 | — | 2 | 3 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 2 | 1 | — | 1 | 3 |
| Parasitemia | D018512 | — | — | — | — | 1 | — | 1 | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | 1 | 2 | — | — | 2 |
| Sexually transmitted diseases | D012749 | — | A50-A64 | — | — | 1 | — | — | 1 |
| Therapeutics | D013812 | — | — | — | — | 1 | — | — | 1 |
Show 5 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | 3 | — | — | 2 | 5 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 2 | — | — | — | 4 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | 2 | — | — | 2 | 4 |
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | 2 | — | — | 1 | 3 |
| Neoplasms | D009369 | — | C80 | 1 | 2 | — | — | — | 3 |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | — | 2 | — | — | — | 2 |
| Systemic lupus erythematosus | D008180 | HP_0002725 | M32 | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 1 | — | — | 1 | 2 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | — | 1 | 2 |
Show 25 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | 1 | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | — | — | — | — | 2 |
| Small cell lung carcinoma | D055752 | — | — | 2 | — | — | — | — | 2 |
| Gliosarcoma | D018316 | — | — | 1 | — | — | — | — | 1 |
| Headache | D006261 | HP_0002315 | R51 | 1 | — | — | — | — | 1 |
| Neck pain | D019547 | HP_0030833 | M54.2 | 1 | — | — | — | — | 1 |
| Sleep wake disorders | D012893 | — | G47 | 1 | — | — | — | — | 1 |
| Long qt syndrome | D008133 | HP_0001657 | I45.81 | 1 | — | — | — | — | 1 |
| Pharmacological phenomena | D000069437 | — | — | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
Show 2 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lupus nephritis | D008181 | EFO_0005761 | — | — | — | — | — | 2 | 2 |
| Nephritis | D009393 | — | N05 | — | — | — | — | 2 | 2 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 1 | 1 |
| Iatrogenic disease | D007049 | — | — | — | — | — | — | 1 | 1 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | — | — | — | 1 | 1 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | — | — | — | — | 1 | 1 |
| Urinalysis | D016482 | — | — | — | — | — | — | 1 | 1 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | — | — | — | 1 | 1 |
| Membranoproliferative glomerulonephritis | D015432 | — | — | — | — | — | — | 1 | 1 |
| Disease resistance | D060467 | — | — | — | — | — | — | 1 | 1 |
Show 12 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Chloroquine |
| INN | chloroquine |
| Description | Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. It has a role as an antimalarial, an antirheumatic drug, a dermatologic drug, an autophagy inhibitor and an anticoronaviral agent. It is an aminoquinoline, a secondary amino compound, a tertiary amino compound and an organochlorine compound. It is a conjugate base of a chloroquine(2+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 |
Identifiers
| PDB | — |
| CAS-ID | 54-05-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL76 |
| ChEBI ID | 3638 |
| PubChem CID | 2719 |
| DrugBank | DB00608 |
| UNII ID | 886U3H6UFF (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PSAP
PSAP
Organism
Homo sapiens
Gene name
PSAP
Gene synonyms
GLBA, SAP1
NCBI Gene ID
Protein name
prosaposin
Protein synonyms
precursor of saposins, Proactivator polypeptide, saposin-A, saposin-B, saposin-C, saposin-D, sphingolipid activator protein-1, sphingolipid activator protein-2
Uniprot ID
Mouse ortholog
Psap (19156)
prosaposin (Q61207)
Variants
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Financial
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Estimated US medical usage
Chloroquine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 67,235 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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63,634 adverse events reported
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