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AboutPricing
Drug ReportsChloroquine
Chloroquine
Aralen, Chloroquine (chloroquine) is a small molecule pharmaceutical. Chloroquine was first approved as Aralen hydrochloride on 1982-01-01. It is used to treat amebiasis, avian malaria, discoid lupus erythematosus, falciparum malaria, and malaria amongst others in the USA. It is known to target mas-related G-protein coupled receptor member X1.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
skin and connective tissue diseasesD017437
immune system diseasesD007154
animal diseasesD000820
Trade Name
FDA
EMA
Chloroquine (discontinued: Aralen, Chloroquine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chloroquine phosphate
Tradename
Company
Number
Date
Products
ARALENSanofiN-006002 DISCN1982-01-01
1 products, RLD
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Chloroquine hydrochloride
Tradename
Company
Number
Date
Products
ARALEN HYDROCHLORIDESanofiN-006002 DISCN1982-01-01
1 products
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Chloroquine phosphate
+
Primaquine phosphate
Tradename
Company
Number
Date
Products
ARALEN PHOSPHATE W/ PRIMAQUINE PHOSPHATESanofiN-014860 DISCN1982-01-01
1 products
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Labels
FDA
EMA
Brand Name
Status
Last Update
chloroquine phosphateANDA2024-12-21
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
malariaEFO_0001068D008288B54
systemic sclerodermaEFO_0000717D012595M34.0
rheumatoid arthritisEFO_0000685D001172M06.9
discoid lupus erythematosus—D008179—
falciparum malariaEFO_0007444D016778B50
pemphigusEFO_1000749D010392L10
amebiasisEFO_0007144D000562A06
avian malaria—D008289—
vivax malariaEFO_0007445D016780B51
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01B: Antimalarials
— P01BA: Aminoquinoline antimalarials
— P01BA01: Chloroquine
— P01BB: Biguanide antimalarials
— P01BB52: Chloroquine and proguanil
HCPCS
Code
Description
J0390
Injection, chloroquine hydrochloride, up to 250 mg
Clinical
Clinical Trials
247 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Rheumatoid arthritisD001172EFO_0000685M06.9———1—1
ArthritisD001168HP_0001369M05-M14———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B54——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameChloroquine
INNchloroquine
Description
Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. It has a role as an antimalarial, an antirheumatic drug, a dermatologic drug, an autophagy inhibitor and an anticoronaviral agent. It is an aminoquinoline, a secondary amino compound, a tertiary amino compound and an organochlorine compound. It is a conjugate base of a chloroquine(2+).
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Identifiers
PDB—
CAS-ID54-05-7
RxCUI—
ChEMBL IDCHEMBL76
ChEBI ID3638
PubChem CID2719
DrugBankDB00608
UNII ID886U3H6UFF (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
PSAP
PSAP
Organism
Homo sapiens
Gene name
PSAP
Gene synonyms
GLBA, SAP1
NCBI Gene ID
5660
Protein name
prosaposin
Protein synonyms
precursor of saposins, Proactivator polypeptide, saposin-A, saposin-B, saposin-C, saposin-D, sphingolipid activator protein-1, sphingolipid activator protein-2
Uniprot ID
P07602
Mouse ortholog
Psap (19156)
prosaposin (Q61207)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Chloroquine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 68,028 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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66,983 adverse events reported
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