Chloroprocaine
Chloroprocaine, Iheezo, Nesacaine, Nesacaine-mpf (chloroprocaine) is a small molecule pharmaceutical. Chloroprocaine was first approved as Nesacaine on 1982-01-01. It is used to treat pain in the USA. It is known to target ryanodine receptor 1 and ryanodine receptor 2.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Chloroprocaine, Iheezo, Nesacaine-mpf (discontinued: Chloroprocaine, Clorotekal, Nesacaine-mpf)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chloroprocaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NESACAINE | Fresenius Kabi | N-009435 RX | 1982-01-01 | 1 products, RLD |
| NESACAINE-MPF | Fresenius Kabi | N-009435 RX | 1996-05-02 | 2 products, RLD, RS |
| IHEEZO | Harrow | N-216227 RX | 2022-09-27 | 1 products, RLD, RS |
Show 3 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| (chloroprocaine hci | New Drug Application | 2024-01-29 |
| chloroprocaine hci | New Drug Application | 2024-01-28 |
| chloroprocaine hydrochloride | ANDA | 2022-02-25 |
| clorotekal | New Drug Application | 2020-12-04 |
| iheezo | New Drug Application | 2023-02-21 |
| nesacaine | New Drug Application | 2024-10-14 |
| nesacaine nesacaine | New Drug Application | 2022-09-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
CHLOROPROCAINE HYDROCHLORIDE, IHEEZO, HARROW EYE | |||
| 2025-09-27 | NP | ||
Clinical
Clinical Trials
47 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal anesthesia | D000775 | — | — | — | 1 | — | 3 | 3 | 7 |
| Anesthesia | D000758 | — | — | 1 | — | — | 1 | 3 | 5 |
| Knee injuries | D007718 | — | — | — | 1 | — | 1 | 3 | 5 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | 3 | — | 4 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | 1 | — | 1 | 1 | 3 |
| Ambulatory surgical procedures | D000556 | — | — | — | — | — | 1 | 2 | 3 |
| Local anesthesia | D000772 | — | — | — | — | 1 | 1 | 1 | 3 |
| Uterine cervical incompetence | D002581 | EFO_0007202 | N88.3 | — | — | — | 2 | — | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | 1 | — | 1 |
| Analgesia | D000698 | — | — | — | — | — | 1 | — | 1 |
Show 7 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | 2 | 1 | — | — | 2 |
| Cataract | D002386 | HP_0000518 | H26.9 | — | — | 1 | — | — | 1 |
| Obstetric labor complications | D007744 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hernia | D006547 | HP_0100790 | K40-K46 | — | 1 | — | — | 1 | 2 |
| Pregnancy rate | D018873 | — | — | — | 1 | — | — | — | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | 1 | — | — | — | 1 |
| Flatfoot | D005413 | EFO_0003874 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cesarean section | D002585 | — | — | 1 | — | — | — | 1 | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Umbilical hernia | D006554 | — | Q79.2 | — | — | — | — | 1 | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 1 | 1 |
| Agnosia | D000377 | HP_0030222 | F88 | — | — | — | — | 1 | 1 |
| Epidural analgesia | D015360 | — | — | — | — | — | — | 1 | 1 |
| General anesthesia | D000768 | — | — | — | — | — | — | 1 | 1 |
| Surgical amputation | D000671 | — | — | — | — | — | — | 1 | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 1 | 1 |
| Phantom limb | D010591 | — | G54.6 | — | — | — | — | 1 | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 1 | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
Show 3 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Chloroprocaine |
| INN | chloroprocaine |
| Description | Chloroprocaine is procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of constricting blood vessels, so reducing bleeding. It has a role as a local anaesthetic, a peripheral nervous system drug and a central nervous system depressant. It is a benzoate ester and a member of monochlorobenzenes. It is functionally related to a 2-diethylaminoethanol and a 4-amino-2-chlorobenzoic acid. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCOC(=O)c1ccc(N)cc1Cl |
Identifiers
| PDB | — |
| CAS-ID | 133-16-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1179047 |
| ChEBI ID | 3636 |
| PubChem CID | 8612 |
| DrugBank | DB01161 |
| UNII ID | 5YVB0POT2H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
RYR1
RYR1
RYR2
RYR2
Organism
Homo sapiens
Gene name
RYR1
Gene synonyms
RYDR
NCBI Gene ID
Protein name
ryanodine receptor 1
Protein synonyms
central core disease of muscle, protein phosphatase 1, regulatory subunit 137, ryanodine receptor 1 (skeletal), sarcoplasmic reticulum calcium release channel, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle-type ryanodine receptor, Type 1 ryanodine receptor, type 1-like ryanodine receptor
Uniprot ID
Mouse ortholog
Ryr1 (20190)
ryanodine receptor 1 (Q99JF9)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 773 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
93 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use