Chloroprocaine
Chloroprocaine, Iheezo, Nesacaine, Nesacaine-mpf (chloroprocaine) is a small molecule pharmaceutical. Chloroprocaine was first approved as Nesacaine on 1982-01-01. It is used to treat pain in the USA. It is known to target ryanodine receptor 1 and ryanodine receptor 2.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Chloroprocaine, Iheezo, Nesacaine-mpf (discontinued: Chloroprocaine, Clorotekal, Nesacaine-mpf)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chloroprocaine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NESACAINE | Fresenius Kabi | N-009435 RX | 1982-01-01 | 1 products, RLD |
| NESACAINE-MPF | Fresenius Kabi | N-009435 RX | 1996-05-02 | 2 products, RLD, RS |
| IHEEZO | Harrow | N-216227 RX | 2022-09-27 | 1 products, RLD, RS |
Show 3 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| (chloroprocaine hci | New Drug Application | 2024-01-29 |
| chloroprocaine hci | New Drug Application | 2024-01-28 |
| chloroprocaine hydrochloride | ANDA | 2022-02-25 |
| clorotekal | New Drug Application | 2020-12-04 |
| iheezo | New Drug Application | 2023-02-21 |
| nesacaine | New Drug Application | 2025-01-09 |
| nesacaine nesacaine | New Drug Application | 2022-09-01 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| pain | EFO_0003843 | D010146 | R52 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
CHLOROPROCAINE HYDROCHLORIDE, IHEEZO, HARROW EYE | |||
| 2025-09-27 | NP | ||
Clinical
Clinical Trials
46 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal anesthesia | D000775 | — | — | — | 1 | — | 3 | 3 | 7 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | 3 | — | 4 |
| Anesthesia | D000758 | — | — | 1 | — | — | 1 | 2 | 4 |
| Knee injuries | D007718 | — | — | — | 1 | — | 1 | 2 | 4 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | 1 | — | 1 | 1 | 3 |
| Ambulatory surgical procedures | D000556 | — | — | — | — | — | 1 | 2 | 3 |
| Local anesthesia | D000772 | — | — | — | — | 1 | 1 | 1 | 3 |
| Uterine cervical incompetence | D002581 | EFO_0007202 | N88.3 | — | — | — | 2 | — | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | 1 | — | 1 |
| Analgesia | D000698 | — | — | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | 2 | 1 | — | — | 2 |
| Cataract | D002386 | EFO_0001059 | H26.9 | — | — | 1 | — | — | 1 |
| Obstetric labor complications | D007744 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hernia | D006547 | — | K40-K46 | — | 1 | — | — | 1 | 2 |
| Pregnancy rate | D018873 | — | — | — | 1 | — | — | — | 1 |
| Postoperative pain | D010149 | — | G89.18 | — | 1 | — | — | — | 1 |
| Flatfoot | D005413 | EFO_0003874 | M21.4 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cesarean section | D002585 | — | — | 1 | — | — | — | 1 | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Umbilical hernia | D006554 | — | K42 | — | — | — | — | 1 | 1 |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 1 | 1 |
| Agnosia | D000377 | EFO_0007136 | F88 | — | — | — | — | 1 | 1 |
| Epidural analgesia | D015360 | — | — | — | — | — | — | 1 | 1 |
| General anesthesia | D000768 | — | — | — | — | — | — | 1 | 1 |
| Surgical amputation | D000671 | — | — | — | — | — | — | 1 | 1 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 1 | 1 |
| Phantom limb | D010591 | — | G54.6 | — | — | — | — | 1 | 1 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | — | — | — | 1 | 1 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Chloroprocaine |
| INN | chloroprocaine |
| Description | Chloroprocaine is procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of constricting blood vessels, so reducing bleeding. It has a role as a local anaesthetic, a peripheral nervous system drug and a central nervous system depressant. It is a benzoate ester and a member of monochlorobenzenes. It is functionally related to a 2-diethylaminoethanol and a 4-amino-2-chlorobenzoic acid. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN(CC)CCOC(=O)c1ccc(N)cc1Cl |
Identifiers
| PDB | — |
| CAS-ID | 133-16-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1179047 |
| ChEBI ID | 3636 |
| PubChem CID | 8612 |
| DrugBank | DB01161 |
| UNII ID | 5YVB0POT2H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
RYR1
RYR1
RYR2
RYR2
Organism
Homo sapiens
Gene name
RYR1
Gene synonyms
RYDR
NCBI Gene ID
Protein name
ryanodine receptor 1
Protein synonyms
central core disease of muscle, protein phosphatase 1, regulatory subunit 137, ryanodine receptor 1 (skeletal), sarcoplasmic reticulum calcium release channel, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle-type ryanodine receptor, Type 1 ryanodine receptor, type 1-like ryanodine receptor
Uniprot ID
Mouse ortholog
Ryr1 (20190)
ryanodine receptor 1 (Q99JF9)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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95 adverse events reported
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